Etfb MGI Mouse Gene Detail - MGI:106098 - electron transferring flavoprotein, beta polypeptide

Symbol

Etfb
Name

electron transferring flavoprotein, beta polypeptide
Synonyms

0610009I16Rik, 2810441H06Rik

Feature Type

protein coding gene
IDs

MGI:106098
NCBI Gene: 110826
Alliance

gene page

Sequence Map

Chr7:43093507-43107224 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 28.25 cM, cytoband B2
Mapping Data

11 experiments

SNPs within 2kb

207 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106098	protein coding gene	Chr7:43093496-43107224 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032125	protein coding gene	Chr7:43458024-43471590 (+)
A/J	MGP_AJ_G0032110	protein coding gene	Chr7:42571016-42584589 (+)
AKR/J	MGP_AKRJ_G0032040	protein coding gene	Chr7:43940781-43954349 (+)
BALB/cJ	MGP_BALBcJ_G0032115	protein coding gene	Chr7:42685786-42699478 (+)
C3H/HeJ	MGP_C3HHeJ_G0031831	protein coding gene	Chr7:44440327-44455165 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0032599	protein coding gene	Chr7:45651755-45666978 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029622	protein coding gene	Chr7:44692686-44706156 (+)
CAST/EiJ	MGP_CASTEiJ_G0031161	protein coding gene	Chr7:35615307-35630344 (+)
CBA/J	MGP_CBAJ_G0031800	protein coding gene	Chr7:47096267-47110090 (+)
DBA/2J	MGP_DBA2J_G0031949	protein coding gene	Chr7:42370773-42384559 (+)
FVB/NJ	MGP_FVBNJ_G0031910	protein coding gene	Chr7:42090550-42104118 (+)
LP/J	MGP_LPJ_G0032028	protein coding gene	Chr7:44196718-44210215 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031946	protein coding gene	Chr7:46046938-46062897 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032619	protein coding gene	Chr7:43069746-43083514 (+)
PWK/PhJ	MGP_PWKPhJ_G0030882	protein coding gene	Chr7:35813343-35828092 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030721	protein coding gene	Chr7:31120180-31133361 (+)
WSB/EiJ	MGP_WSBEiJ_G0031275	protein coding gene	Chr7:43612555-43626217 (+)

Human Ortholog

ETFB, electron transfer flavoprotein subunit beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ETFB, electron transfer flavoprotein subunit beta
Synonyms

FP585, MADD
Links

HGNC:3482

NCBI Gene ID: 2109

neXtProt AC: NX_P38117

UniProt: P38117
Chr Location

19q13.41; chr19:51345155-51366418 (-) GRCh38.p7

Alliance of Genome Resources

Etfb stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ETFB
Protein SuperFamily

Beta-ETF
Gene Tree

Etfb

Diseases

1 with human ETFB associations

				Human Disease	Mouse Models
				multiple acyl-CoA dehydrogenase deficiency IDs multiple acyl-CoA dehydrogenase deficiency DOID:0060358 ICD10CM:E71.313 MESH:D054069 NCI:C84907 OMIM:231680 ORDO:26791 UMLS_CUI:C0268596 UMLS_CUI:C1856401 UMLS_CUI:C1856403 UMLS_CUI:C1856405

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotype references

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

13 strains or lines available

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All GO Annotations

14
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

101
cDNA Data

10
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase etfb

ZFIN etfb

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Etfb interacts with 17 markers (Mir34b, Mir34c, Mir124a-1, ...) View All

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All Sequences

53
RefSeq

3
UniProt

5
CCDS

CCDS21171.1

Ensembl

ENSMUSG00000004610 (Evidence)
NCBI Gene

110826

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004610	Ensembl Gene Model \| MGI Sequence Detail	13718	C57BL/6J	± kb
transcript	ENSMUST00000004729	Ensembl \| MGI Sequence Detail	893	Not Applicable
polypeptide	ENSMUSP00000004729	Ensembl \| MGI Sequence Detail	255	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000007216 electron transfer flavoprotein subunit beta

(term hierarchy)
InterPro Domains

IPR014730 Electron transfer flavoprotein, alpha/beta-subunit, N-terminal

IPR012255 Electron transfer flavoprotein, beta subunit

IPR000049 Electron transfer flavoprotein, beta-subunit, conserved site

IPR033948 Electron transfer flavoprotein, beta subunit, N-terminal

IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

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All nucleic 14

cDNA 14

Microarray probesets 3

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MGD-MRK-33785, MGI:1915610, MGI:1920006

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 2
Earliest

J:320288 Finocchiaro G, et al., cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein. Eur J Biochem. 1993 May 1;213(3):1003-8
Latest

J:285347 Zhang X, et al., Hepatic neddylation targets and stabilizes electron transfer flavoproteins to facilitate fatty acid beta-oxidation. Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2473-2483

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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