Tfap2c MGI Mouse Gene Detail - MGI:106032 - transcription factor AP-2, gamma

Symbol

Tfap2c
Name

transcription factor AP-2, gamma
Synonyms

Ap-2.2, AP2gamma, Stra2, Tcfap2c

Feature Type

protein coding gene
IDs

MGI:106032
NCBI Gene: 21420
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr2:172391513-172400542 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 94.87 cM, cytoband H3-H4
Mapping Data

2 experiments

SNPs within 2kb

80 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106032	protein coding gene	Chr2:172387599-172400542 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026948	protein coding gene	Chr2:178738634-178749261 (+)
A/J	MGP_AJ_G0026915	protein coding gene	Chr2:171248940-171258342 (+)
AKR/J	MGP_AKRJ_G0026886	protein coding gene	Chr2:176418679-176426730 (+)
BALB/cJ	MGP_BALBcJ_G0026924	protein coding gene	Chr2:171647239-171655991 (+)
C3H/HeJ	MGP_C3HHeJ_G0026666	protein coding gene	Chr2:176778493-176779895 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027371	protein coding gene	Chr2:183896352-183910162 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024741	protein coding gene	Chr2:164497703-164506651 (+)
CAST/EiJ	MGP_CASTEiJ_G0026124	protein coding gene	Chr2:177459015-177470671 (+)
CBA/J	MGP_CBAJ_G0026643	protein coding gene	Chr2:190772165-190773567 (+)
DBA/2J	MGP_DBA2J_G0026781	protein coding gene	Chr2:170344453-170354372 (+)
FVB/NJ	MGP_FVBNJ_G0026747	protein coding gene	Chr2:168946243-168955656 (+)
LP/J	MGP_LPJ_G0026882	protein coding gene	Chr2:178665492-178676387 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026766	protein coding gene	Chr2:193753295-193765971 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027428	protein coding gene	Chr2:176389626-176409029 (+)
PWK/PhJ	MGP_PWKPhJ_G0025861	protein coding gene	Chr2:170118979-170128293 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025661	protein coding gene	Chr2:175390541-175399430 (+)
WSB/EiJ	MGP_WSBEiJ_G0026197	protein coding gene	Chr2:177369105-177382809 (+)

Human Ortholog

TFAP2C, transcription factor AP-2 gamma

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TFAP2C, transcription factor AP-2 gamma
Synonyms

AP2-GAMMA, ERF1, hAP-2g, TFAP2G
Links

HGNC:11744

NCBI Gene ID: 7022

neXtProt AC: NX_Q92754

UniProt: Q92754
Chr Location

20q13.31; chr20:56629306-56639283 (+) GRCh38

MGI Vertebrate Homology

Tfap2c stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TFAP2C
Gene Tree

Tfap2c

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Phenotype Summary

29 phenotypes from 4 alleles in 4 genetic backgrounds
28 phenotypes from multigenic genotypes
4 images
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

2
Gene trapped

1
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous inactivation of this gene leads to embryonic growth retardation, failure to establish a normal maternal-embryonic interface, malformed extra-embryonic tissues, and early embryonic lethality due to placental malfunction.

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All GO Annotations

45
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1145
Tissues

279
cDNA Data

106
Literature Summary

69

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TFAP2C

Xenbase tfap2c

ZFIN tfap2c

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All Sequences

56
RefSeq

10
UniProt

5
CCDS

CCDS17135.1, CCDS50810.1

Ensembl

ENSMUSG00000028640 (Evidence)
NCBI Gene

21420

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028640	Ensembl Gene Model \| MGI Sequence Detail	9030	C57BL/6J	± kb
transcript	ENSMUST00000099058	Ensembl \| MGI Sequence Detail	2985	Not Applicable
polypeptide	ENSMUSP00000096657	Ensembl \| MGI Sequence Detail	513	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016265 transcription factor AP-2 gamma

(term hierarchy)
InterPro Domains

IPR004979 Transcription factor AP-2

IPR013854 Transcription factor AP-2, C-terminal

IPR008123 Transcription factor AP-2 gamma

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All nucleic 120

Genomic 1

cDNA 108

Primer pair 9

Other 2

Microarray probesets 5

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MGD-MRK-33716, MGD-MRK-36502, MGI:107922, MGI:2138767

Summaries

All 122

Developmental Gene Expression 69

Gene Ontology 16

Phenotypes 23
Earliest

J:7873 Keitges E, et al., X-linkage of steroid sulphatase in the mouse is evidence for a functional Y-linked allele. Nature. 1985 May 16-22;315(6016):226-7
Latest

J:345904 Li L, et al., Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos. Nat Struct Mol Biol. 2024 Jan 19;

TSS for Tfap2c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21966	Chr2:172391501-172391525 (+)	0 bp
Tssr21967	Chr2:172391556-172391569 (+)	50 bp
Tssr21968	Chr2:172392681-172392687 (+)	1,171 bp
Tssr21969	Chr2:172392948-172392963 (+)	1,443 bp
Tssr21970	Chr2:172393423-172393438 (+)	1,918 bp
Tssr21971	Chr2:172393442-172393455 (+)	1,936 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23