Gucy2g MGI Mouse Gene Detail - MGI:106025

Symbol

Gucy2g
Name

guanylate cyclase 2g
Synonyms

2410077I05Rik, GC-G

Feature Type

protein coding gene
IDs

MGI:106025
NCBI Gene: 73707
Alliance

genome feature page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:55186531-55229668 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 51.18 cM, cytoband D2
Mapping Data

4 experiments

SNPs within 2kb

1594 from dbSNP Build 142
Strain Annotations

19
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106025	protein coding gene	Chr19:55186531-55229684 (-)
129S1/SvImJ	ENSMUSG00200014518	protein coding gene	Chr19:51888275-51931146 (-)
A/J	ENSMUSG00195002475	protein coding gene	Chr19:52063557-52106700 (-)
AKR/J	ENSMUSG00220017174	protein coding gene	Chr19:51816063-51859233 (-)
BALB/cJ	ENSMUSG00180018401	protein coding gene	Chr19:52302739-52345872 (-)
C3H/HeJ	ENSMUSG00175021037	protein coding gene	Chr19:51838368-51881522 (-)
C57BL/6NJ	ENSMUSG00215016110	protein coding gene	Chr19:51922420-51965558 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023082	protein coding gene	Chr19:51667689-51709796 (-)
CAST/EiJ	ENSTCUG00005014345	protein coding gene	Chr19:51474084-51517130 (-)
CBA/J	ENSMUSG00210021069	protein coding gene	Chr19:51917802-51960953 (-)
DBA/2J	ENSMUSG00185026753	protein coding gene	Chr19:52416490-52459649 (-)
FVB/NJ	ENSMUSG00205003216	protein coding gene	Chr19:51296923-51340097 (-)
JF1/MsJ	ENSUMUG00000017181	protein coding gene	Chr19:52602454-52645349 (-)
LP/J	ENSMUSG00230027507	protein coding gene	Chr19:53169854-53212720 (-)
NOD/ShiLtJ	ENSMUSG00190011887	protein coding gene	Chr19:51790785-51833652 (-)
NZO/HlLtJ	ENSMUSG00225025169	protein coding gene	Chr19:56775186-56818340 (-)
PWK/PhJ	ENSLUMG00010018116	protein coding gene	Chr19:51658360-51701261 (-)
SPRET/EiJ	ENSMSPG00010003025	protein coding gene	Chr19:51518303-51560746 (-)
WSB/EiJ	ENSIUOG00005024005	protein coding gene	Chr19:51277117-51320029 (-)

Human Ortholog

GUCY2GP, guanylate cyclase 2G, pseudogene

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GUCY2GP, guanylate cyclase 2G, pseudogene
Synonyms

GUCY2G
Links

HGNC:31863

NCBI Gene ID: 390003
Chr Location

10q25.2; chr10:112308178-112356595 (-) GRCh38

MGI Vertebrate Homology

Gucy2g stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GUCY2GP
Gene Tree

Gucy2g

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

1
Targeted

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available

Mice homozygous for a null mutation are viable and fertile with no gross abnormalities and are protected against acute ischemia induced renal injury.

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All GO Annotations

20
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

636
Tissues

25
cDNA Data

5
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

10
UniProt

1
CCDS

CCDS38026.1

Ensembl

ENSMUSG00000055523 (Evidence)
NCBI Gene

73707

			Length	Strain/Species	Flank
genomic	ENSMUSG00000055523	Ensembl Gene Model \| MGI Sequence Detail	43138	C57BL/6J	± kb
transcript	ENSMUST00000069183	Ensembl \| MGI Sequence Detail	3888	Not Applicable
polypeptide	ENSMUSP00000068253	Ensembl \| MGI Sequence Detail	1100	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008397 guanylate cyclase 2G

(term hierarchy)
EC

4.6.1.2
InterPro Domains

IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase

IPR001170 Adenylyl cyclase class-4/guanylyl cyclase

IPR018297 Adenylyl cyclase class-4/guanylyl cyclase, conserved site

IPR050401 Cyclic nucleotide synthase

IPR029787 Nucleotide cyclase

IPR028082 Periplasmic binding protein-like I

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001828 Receptor, ligand binding region

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
GlyGen

Q6TL19 9 sites

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All nucleic 8

cDNA 5

Primer pair 3

Microarray probesets 2

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MGD-MRK-33707, MGI:1920957

Summaries

All 43

Developmental Gene Expression 3

Gene Ontology 8

Phenotypes 10
Earliest

J:31346 Yang RB, et al., Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Genomics. 1996 Feb 1;31(3):367-72
Latest

J:258316 Chao YC, et al., Guanylyl cyclase-G is an alarm pheromone receptor in mice. EMBO J. 2018 Jan 4;37(1):39-49

TSS for Gucy2g:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr159857	Chr19:55205998-55206009 (-)	23,664 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29