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St8sia4 Gene Detail
Summary
  • Symbol
    St8sia4
  • Name
    ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
  • Synonyms
    PST, PST-1, Siat8d, ST8SiaIV
  • Feature Type
    protein coding gene
  • IDs
    MGI:106018
    NCBI Gene: 20452
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:95515407-95595296 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 47.76 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2283 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_106018
protein coding gene Chr1:95515407-95595473 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016355
protein coding gene Chr1:97301456-97383804 (-)
A/J MGP_AJ_G0016339
protein coding gene Chr1:93831764-93912929 (-)
AKR/J MGP_AKRJ_G0016300
protein coding gene Chr1:96591798-96672649 (-)
BALB/cJ MGP_BALBcJ_G0016295
protein coding gene Chr1:94017081-94097036 (-)
C3H/HeJ MGP_C3HHeJ_G0016121
protein coding gene Chr1:96841074-96924794 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016754
protein coding gene Chr1:101151585-101233881 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014472
protein coding gene Chr1:88337438-88419991 (-)
CAST/EiJ MGP_CASTEiJ_G0015704
protein coding gene Chr1:96175792-96258401 (-)
CBA/J MGP_CBAJ_G0016095
protein coding gene Chr1:104394736-104482956 (-)
DBA/2J MGP_DBA2J_G0016200
protein coding gene Chr1:93059630-93141446 (-)
FVB/NJ MGP_FVBNJ_G0016201
protein coding gene Chr1:92095993-92177591 (-)
LP/J MGP_LPJ_G0016274
protein coding gene Chr1:98550720-98633929 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016227
protein coding gene Chr1:107669642-107806311 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016793
protein coding gene Chr1:96604201-96685306 (-)
PWK/PhJ MGP_PWKPhJ_G0015492
protein coding gene Chr1:92350191-92432032 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015276
protein coding gene Chr1:95467488-95548897 (-)
WSB/EiJ MGP_WSBEiJ_G0015767
protein coding gene Chr1:96425060-96509410 (-)



Homology
more
  • Human Ortholog
    ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ST8SIA4, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
  • Synonyms
    PST, PST1, SIAT8D, SIAT8-D, ST8SiaIV, ST8SIA-IV
  • Links
    NCBI Gene ID: 7903
    neXtProt AC: NX_Q92187
    UniProt: Q92187

  • Chr Location
    5q21.1; chr5:100806933-100903282 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    25 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null adult mice exhibit impaired long term potentiation and impaired long term depression in hippocampal CA1 synapses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040710 Ensembl Gene Model | MGI Sequence Detail 79890 C57BL/6J ±  kb
transcript ENSMUST00000043336 Ensembl | MGI Sequence Detail 5390 Not Applicable  
polypeptide ENSMUSP00000043477 Ensembl | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 52
    Genomic 5
    cDNA 42
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33700
References
more
  • Summaries
    All 79
    Developmental Gene Expression 11
    Gene Ontology 5
    Phenotypes 39
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:346672 Varbanov H, et al., Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments. Neurobiol Dis. 2023 Mar 12;180:106079

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory