Anxa5 MGI Mouse Gene Detail - MGI:106008

Symbol

Anxa5
Name

annexin A5
Synonyms

annexin V, Anx5

Feature Type

protein coding gene
IDs

MGI:106008
NCBI Gene: 11747
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr3:36503072-36530036 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 17.46 cM
Mapping Data

11 experiments

SNPs within 2kb

994 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_106008	protein coding gene	Chr3:36503072-36530043 (-)
129S1/SvImJ	ENSMUSG00200005808	protein coding gene	Chr3:33234968-33268307 (-)
A/J	ENSMUSG00195001410	protein coding gene	Chr3:33224207-33251106 (-)
AKR/J	ENSMUSG00220000544	protein coding gene	Chr3:33262060-33295380 (-)
BALB/cJ	ENSMUSG00180002620	protein coding gene	Chr3:33357146-33384133 (-)
C3H/HeJ	ENSMUSG00175003195	protein coding gene	Chr3:33254298-33281204 (-)
C57BL/6NJ	ENSMUSG00215001494	protein coding gene	Chr3:33631114-33658104 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024937	protein coding gene	Chr3:31291460-31320385 (-)
CAST/EiJ	ENSTCUG00005001030	protein coding gene	Chr3:33088520-33115626 (-)
CBA/J	ENSMUSG00210001420	protein coding gene	Chr3:33302462-33329361 (-)
DBA/2J	ENSMUSG00185000943	protein coding gene	Chr3:33501983-33528943 (-)
FVB/NJ	ENSMUSG00205000440	protein coding gene	Chr3:32683539-32710553 (-)
JF1/MsJ	ENSUMUG00000000471	protein coding gene	Chr3:33049393-33076369 (-)
LP/J	ENSMUSG00230018540	protein coding gene	Chr3:35477924-35511267 (-)
NOD/ShiLtJ	ENSMUSG00190001019	protein coding gene	Chr3:33546227-33573205 (-)
NZO/HlLtJ	ENSMUSG00225006535	protein coding gene	Chr3:38103369-38130277 (-)
PWK/PhJ	ENSLUMG00010000571	protein coding gene	Chr3:33057036-33084098 (-)
SPRET/EiJ	ENSMSPG00010000486	protein coding gene	Chr3:33491528-33518517 (-)
WSB/EiJ	ENSIUOG00005012542	protein coding gene	Chr3:33545096-33571998 (-)

Human Ortholog

ANXA5, annexin A5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANXA5, annexin A5
Synonyms

ANX5, CPB-I, ENX2, HEL-S-7, PP4, RPRGL3, VAC-alph
Links

HGNC:543

NCBI Gene ID: 308

UniProt: P08758
Chr Location

4q27; chr4:121667396-121697061 (-) GRCh38

MGI Vertebrate Homology

Anxa5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: ANXA5
Gene Tree

Anxa5

Diseases

3 with human ANXA5 associations

				Human Disease	Mouse Models
				autoimmune disease of the nervous system IDs autoimmune disease of the nervous system DOID:438 MESH:D020274 NCI:C99383 UMLS_CUI:C0751871
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051
				systemic scleroderma IDs systemic scleroderma DOID:418 EFO:0000717 ICD10CM:M34.0 ICD9CM_2006:710.1 ICD9CM:710.1 MESH:D012595 NCI:C72070 OMIM:181750 UMLS_CUI:C0036421

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 2 genetic backgrounds
5 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

6
Gene trapped

1
Radiation induced

1
Targeted

2
Genomic Mutations

1 involving Anxa5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Homozygous null mice are viable, fertile, and develop normally. Bone development and maintenance are normal, as are clinical-chemical parameters.

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All GO Annotations

38
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

956
Tissues

123
cDNA Data

182
Literature Summary

27

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ANXA5

Xenbase anxa5

ZFIN anxa5a, anxa5b

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS38416.1

Ensembl

ENSMUSG00000027712 (Evidence)
NCBI Gene

11747

			Length	Strain/Species	Flank
genomic	11747	NCBI Gene Model \| MGI Sequence Detail	26965	C57BL/6J	± kb
transcript	NM_009673	RefSeq \| MGI Sequence Detail	1738	ZRU/MplStud
polypeptide	P48036	UniProt \| EBI \| MGI Sequence Detail	319	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004078 annexin A5

(term hierarchy)
InterPro Domains

IPR001464 Annexin

IPR002392 Annexin A5

IPR018502 Annexin repeat

IPR018252 Annexin repeat, conserved site

IPR037104 Annexin superfamily
GlyGen

P48036 1 site, 1 O-linked glycan (1 site)

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All nucleic 194

Genomic 5

cDNA 183

Primer pair 6

Antibodies 3

Microarray probesets 3

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MGD-MRK-33688, MGI:2140106

Summaries

All 104

Developmental Gene Expression 27

Diseases 1

Gene Ontology 16

Phenotypes 21
Earliest

J:35723 Chepenik KP, et al., Developmental regulation of various annexins in the embryonic palate of the mouse: dexamethasone affects expression of annexin-1. J Craniofac Genet Dev Biol. 1995 Oct-Dec;15(4):171-81
Latest

J:346054 Baur K, et al., Growth/differentiation factor 15 controls ependymal and stem cell number in the V-SVZ. Stem Cell Reports. 2024 Mar 12;19(3):351-365

TSS for Anxa5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr33029	Chr3:36528675-36528679 (-)	1,359 bp
Tssr33028	Chr3:36523101-36523114 (-)	6,928 bp
Tssr33027	Chr3:36523069-36523097 (-)	6,953 bp
Tssr33026	Chr3:36516120-36516150 (-)	13,901 bp
Tssr33025	Chr3:36507688-36507742 (-)	22,321 bp
Tssr33024	Chr3:36507646-36507686 (-)	22,370 bp
Tssr33023	Chr3:36504810-36504854 (-)	25,204 bp
Tssr33022	Chr3:36503495-36503512 (-)	26,532 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24