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Cox8a Gene Detail
Summary
  • Symbol
    Cox8a
  • Name
    cytochrome c oxidase subunit 8A
  • Synonyms
    COX8L, COX VIII-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:105959
    NCBI Gene: 12868
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:7192523-7194981 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.28 cM, cytoband A
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    19 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105959
 protein coding gene Chr19:7192518-7194981 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024786
 protein coding gene Chr19:4335201-4337658 (-)
A/J MGP_AJ_G0024753
 protein coding gene Chr19:3982511-3984965 (-)
AKR/J MGP_AKRJ_G0024726
 protein coding gene Chr19:4116963-4119421 (-)
BALB/cJ MGP_BALBcJ_G0024753
 protein coding gene Chr19:4102430-4104889 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0025199
 protein coding gene Chr19:4419490-4421980 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022633
 protein coding gene Chr19:3886273-3888907 (-)
CAST/EiJ MGP_CASTEiJ_G0023993
 protein coding gene Chr19:4149366-4151802 (-)
CBA/J MGP_CBAJ_G0024493
 protein coding gene Chr19:4497210-4499698 (-)
DBA/2J MGP_DBA2J_G0024620
 protein coding gene Chr19:3953758-3956215 (-)
FVB/NJ MGP_FVBNJ_G0024585
 protein coding gene Chr19:3991035-3993487 (-)
LP/J MGP_LPJ_G0024706
 protein coding gene Chr19:4185881-4189664 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024615
 protein coding gene Chr19:4384990-4389012 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025247
 protein coding gene Chr19:4261275-4263735 (-)
PWK/PhJ MGP_PWKPhJ_G0023739
 protein coding gene Chr19:4004368-4006595 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023543
 protein coding gene Chr19:4060913-4063348 (-)
WSB/EiJ MGP_WSBEiJ_G0024055
 protein coding gene Chr19:4158145-4162025 (-)



Homology
more
  • Human Ortholog
    COX8A, cytochrome c oxidase subunit 8A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COX8A, cytochrome c oxidase subunit 8A
  • Synonyms
    COX, COX8, COX8-2, COX8L, MC4DN15, VIII, VIII-L
  • Links
    NCBI Gene ID: 1351
    neXtProt AC: NX_P10176
    UniProt: P10176

  • Chr Location
    11q13.1; chr11:63974620-63976543 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human COX8A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    407
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12868 NCBI Gene Model | MGI Sequence Detail 2459 C57BL/6J ±  kb
transcript NM_007750 RefSeq | MGI Sequence Detail 545 C57BL/6  
polypeptide Q64445 UniProt | EBI | MGI Sequence Detail 69 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 409
    cDNA 407
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33638
References
more
  • Summaries
    All 40
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:22802 Lomax MI, et al., Structure and chromosomal location of the bovine gene for the heart muscle isoform of cytochrome c oxidase subunit VIII. Mamm Genome. 1995 Feb;6(2):118-22
  • Latest
    J:345617 Beutner G, et al., Coordinated metabolic responses to cyclophilin D deletion in the developing heart. iScience. 2024 Mar 15;27(3):109157
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory