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Inhbc Gene Detail
Summary
  • Symbol
    Inhbc
  • Name
    inhibin beta-C
  • Synonyms
    activin beta-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:105932
    NCBI Gene: 16325
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127192191-127206300 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    89 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105932
 protein coding gene Chr10:127192191-127206417 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017821
 protein coding gene Chr10:130948751-130968282 (-)
A/J MGP_AJ_G0017796
 protein coding gene Chr10:125710916-125725216 (-)
AKR/J MGP_AKRJ_G0017759
 protein coding gene Chr10:129422331-129438624 (-)
BALB/cJ MGP_BALBcJ_G0017760
 protein coding gene Chr10:126117210-126134248 (-)
C3H/HeJ MGP_C3HHeJ_G0017584
 protein coding gene Chr10:129575484-129591001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018215
 protein coding gene Chr10:135387631-135412042 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015895
 protein coding gene Chr10:119706535-119720573 (-)
CAST/EiJ MGP_CASTEiJ_G0017144
 protein coding gene Chr10:130229072-130243586 (-)
CBA/J MGP_CBAJ_G0017553
 protein coding gene Chr10:140845324-140867263 (-)
DBA/2J MGP_DBA2J_G0017659
 protein coding gene Chr10:124794039-124808059 (-)
FVB/NJ MGP_FVBNJ_G0017654
 protein coding gene Chr10:123736778-123751771 (-)
LP/J MGP_LPJ_G0017733
 protein coding gene Chr10:131527453-131544536 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017682
 protein coding gene Chr10:143556612-143573182 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018255
 protein coding gene Chr10:129487028-129505322 (-)
PWK/PhJ MGP_PWKPhJ_G0016929
 protein coding gene Chr10:124999609-125013862 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016721
 protein coding gene Chr10:128527328-128547737 (-)
WSB/EiJ MGP_WSBEiJ_G0017205
 protein coding gene Chr10:129717092-129732253 (-)



Homology
more
  • Human Ortholog
    INHBC, inhibin subunit beta C
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INHBC, inhibin subunit beta C
  • Synonyms
    IHBC
  • Links
    NCBI Gene ID: 3626
    neXtProt AC: NX_P55103
    UniProt: P55103

  • Chr Location
    12q13.3; chr12:57434784-57452062 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display decreased serum albumin in females but are fertile with normal liver and reproductive morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    757
  • Tissues
    41
  • cDNA Data
    19
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025405 Ensembl Gene Model | MGI Sequence Detail 14110 C57BL/6J ±  kb
    transcript ENSMUST00000026472 Ensembl | MGI Sequence Detail 1859 Not Applicable  
    polypeptide ENSMUSP00000026472 Ensembl | MGI Sequence Detail 352 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 11
      cDNA 19
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33611
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 8
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:16240 Lu RZ, et al., Developmental expression of activin/inhibin beta A, beta B, and alpha subunits, and activin receptor-IIB genes in preimplantation mouse embryos. Biol Reprod. 1993 Dec;49(6):1163-9
    • Latest
      J:302094 Marino FE, et al., Activin-betaC modulates gonadal, but not adrenal tumorigenesis in the inhibin deficient mice. Mol Cell Endocrinol. 2015 Jul 5;409:41-50
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory