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Atf6b Gene Detail
Summary
  • Symbol
    Atf6b
  • Name
    activating transcription factor 6 beta
  • Synonyms
    ATF6beta, Crebl1, Creb-rp
  • Feature Type
    protein coding gene
  • IDs
    MGI:105121
    NCBI Gene: 12915
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34866120-34874048 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.22 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105121
 protein coding gene Chr17:34866120-34874048 (+)
129S1/SvImJ ENSMUSG00200047525
 protein coding gene Chr17:30569288-30577218 (+)
A/J ENSMUSG00195035618
 protein coding gene Chr17:31470491-31478436 (+)
AKR/J ENSMUSG00220039501
 protein coding gene Chr17:30498111-30506056 (+)
BALB/cJ ENSMUSG00180032424
 protein coding gene Chr17:30840381-30848308 (+)
C3H/HeJ ENSMUSG00175027624
 protein coding gene Chr17:30384218-30392161 (+)
C57BL/6NJ ENSMUSG00215046374
 protein coding gene Chr17:30409455-30417385 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021471
 protein coding gene Chr17:31434735-31442651 (+)
CAST/EiJ ENSTCUG00005050629
 protein coding gene Chr17:31428603-31436537 (+)
CBA/J ENSMUSG00210044130
 protein coding gene Chr17:30206324-30214267 (+)
DBA/2J ENSMUSG00185042349
 protein coding gene Chr17:32859654-32867581 (+)
FVB/NJ ENSMUSG00205037550
 protein coding gene Chr17:30727842-30735795 (+)
JF1/MsJ ENSUMUG00000048337
 protein coding gene Chr17:32112250-32120217 (+)
LP/J ENSMUSG00230054532
 protein coding gene Chr17:33967567-33975495 (+)
NOD/ShiLtJ ENSMUSG00190039509
 protein coding gene Chr17:30330276-30338207 (+)
NZO/HlLtJ ENSMUSG00225053046
 protein coding gene Chr17:35981046-35988995 (+)
PWK/PhJ ENSLUMG00010043957
 protein coding gene Chr17:29937971-29945909 (+)
SPRET/EiJ ENSMSPG00010041814
 protein coding gene Chr17:31129132-31138058 (+)
WSB/EiJ ENSIUOG00005049475
 protein coding gene Chr17:31056794-31064720 (+)



Homology
more
  • Human Ortholog
    ATF6B, activating transcription factor 6 beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ATF6B, activating transcription factor 6 beta
  • Synonyms
    ATF6beta, CREBL1, CREB-RP, G13
  • Links
    NCBI Gene ID: 1388
    UniProt: Q99941

  • Chr Location
    6p21.32; chr6:32115264-32128253 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased cellular sensitivity to thapsigargin and tunicamycin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    38
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    937
  • Tissues
    213
  • cDNA Data
    64
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12915 NCBI Gene Model | MGI Sequence Detail 7929 C57BL/6J ±  kb
transcript NM_017406 RefSeq | MGI Sequence Detail 2586 ZRU/MplStud  
polypeptide O35451 UniProt | EBI | MGI Sequence Detail 699 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004403 cyclic AMP-dependent transcription factor ATF-6 beta
    (term hierarchy)
  • InterPro Domains
    IPR051882 ATF bZIP Transcription Factors
    IPR004827 Basic-leucine zipper domain
    IPR046347 Basic-leucine zipper domain superfamily
  • GlyGen
    O35451 6 sites, 3 N-linked glycans (5 sites)
Molecular
Reagents
less
  • All nucleic 68
    Genomic 1
    cDNA 65
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-32162, MGI:2146775
References
more
  • Summaries
    All 61
    Developmental Gene Expression 11
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:22448 Matsumoto K, et al., The distribution of tenascin-X is distinct and often reciprocal to that of tenascin-C. J Cell Biol. 1994 Apr;125(2):483-93
  • Latest
    J:367907 Nguyen LD, et al., Impact of ATF6 deletion on the embryonic brain development. iScience. 2025 Jun 20;28(6):112569
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory