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Rps2 Gene Detail
Summary
  • Symbol
    Rps2
  • Name
    ribosomal protein S2
  • Synonyms
    Llrep3, Rps2
  • Feature Type
    protein coding gene
  • IDs
    MGI:105110
    NCBI Gene: 16898
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24939037-24940901 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.51 cM, cytoband A3.3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105110
protein coding gene Chr17:24937090-24940903 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023318
protein coding gene Chr17:23731905-23736885 (+)
A/J MGP_AJ_G0023278
protein coding gene Chr17:23083116-23086847 (+)
AKR/J MGP_AKRJ_G0023245
protein coding gene Chr17:23162042-23165773 (+)
BALB/cJ MGP_BALBcJ_G0023283
protein coding gene Chr17:23278141-23284080 (+)
C3H/HeJ MGP_C3HHeJ_G0023043
protein coding gene Chr17:23521989-23529406 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023726
protein coding gene Chr17:24784379-24788114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021201
protein coding gene Chr17:20551908-20556240 (+)
CAST/EiJ MGP_CASTEiJ_G0022545
protein coding gene Chr17:23379898-23384038 (+)
CBA/J MGP_CBAJ_G0023019
protein coding gene Chr17:25635964-25642463 (+)
DBA/2J MGP_DBA2J_G0023148
protein coding gene Chr17:22677360-22679767 (+)
FVB/NJ MGP_FVBNJ_G0023118
protein coding gene Chr17:22394878-22399020 (+)
LP/J MGP_LPJ_G0023225
protein coding gene Chr17:24044775-24045251 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023137
protein coding gene Chr17:25331129-25332909 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023764
protein coding gene Chr17:23444175-23447856 (+)
PWK/PhJ MGP_PWKPhJ_G0022294
protein coding gene Chr17:21424393-21426408 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022119
protein coding gene Chr17:21648705-21649879 (-)
WSB/EiJ MGP_WSBEiJ_G0022608
protein coding gene Chr17:23520273-23522004 (+)



Homology
more
  • Human Ortholog
    RPS2, ribosomal protein S2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS2, ribosomal protein S2
  • Synonyms
    LLREP3, S2, uS5
  • Links
    NCBI Gene ID: 6187
    neXtProt AC: NX_P15880
    UniProt: P15880

  • Chr Location
    16p13.3; chr16:1962058-1964841 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an allele with a point mutation die prior to weaning. Mice heterozygous for the allele exhibit reduced body fat, mild muscle weakness, and increased circulating creatine kinase level.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16898 NCBI Gene Model | MGI Sequence Detail 1865 C57BL/6J ±  kb
    transcript NM_008503 RefSeq | MGI Sequence Detail 1005 C57BL/6  
    polypeptide P25444 UniProt | EBI | MGI Sequence Detail 293 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000014263 eukaryotic-type small ribosomal subunit protein uS5
    • PDB
    • InterPro Domains
      IPR020568 Ribosomal protein uS5 domain 2-type superfamily
      IPR000851 Small ribosomal subunit protein uS5
      IPR005324 Small ribosomal subunit protein uS5, C-terminal
      IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
      IPR005711 Small ribosomal subunit protein uS5, eukaryotic/archaeal
      IPR013810 Small ribosomal subunit protein uS5, N-terminal
      IPR018192 Small ribosomal subunit protein uS5, N-terminal, conserved site
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 26
      Other 1

      Microarray probesets 17
    Other
    Accession IDs
    less
    MGD-MRK-32150
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 8
    • Earliest
      J:19957 Heller DL, et al., A highly conserved mouse gene with a propensity to form pseudogenes in mammals. Mol Cell Biol. 1988 Jul;8(7):2797-803
    • Latest
      J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/19/2024
    MGI 6.23
    The Jackson Laboratory