Cd55b MGI Mouse Gene Detail - MGI:104849 - CD55 molecule, decay accelerating factor for complement B

Symbol

Cd55b
Name

CD55 molecule, decay accelerating factor for complement B
Synonyms

complement-transmembrane, Daf2, Daf-TM, TM-DAF

Feature Type

protein coding gene
IDs

MGI:104849
NCBI Gene: 13137
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:130316274-130350746 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.89 cM
Mapping Data

6 experiments

SNPs within 2kb

241 from dbSNP Build 142
Strain Annotations

13

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104849	protein coding gene	Chr1:130316263-130350831 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016433	protein coding gene	Chr1:133714231-133796707 (-)
A/J	MGP_AJ_G0016416	protein coding gene	Chr1:128776247-128825887 (-)
AKR/J	MGP_AKRJ_G0016381	protein coding gene	Chr1:132621118-132705328 (-)
BALB/cJ	MGP_BALBcJ_G0016376	protein coding gene	Chr1:129112693-129188040 (-)
C3H/HeJ	MGP_C3HHeJ_G0016202	protein coding gene	Chr1:132803122-132837226 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016838	protein coding gene	Chr1:138747856-138767022 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014551	protein coding gene	Chr1:121967424-122058092 (-)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0016281	protein coding gene	Chr1:127784958-127797532 (-)
FVB/NJ	MGP_FVBNJ_G0016280	protein coding gene	Chr1:126469128-126514095 (-)
LP/J	MGP_LPJ_G0016352	protein coding gene	Chr1:135080907-135165207 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016306	protein coding gene	Chr1:149340147-149371425 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016873	protein coding gene	Chr1:132336264-132400108 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

CD55, CD55 molecule (Cromer blood group)

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CD55, CD55 molecule (Cromer blood group)
Synonyms

CHAPLE, CR, CROM, DAF, TC
Links

HGNC:2665

NCBI Gene ID: 1604

neXtProt AC: NX_P08174

UniProt: P08174
Chr Location

1q32.2; chr1:207321519-207386804 (+) GRCh38

MGI Vertebrate Homology

Cd55b stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CD55
Gene Tree

Cd55b

Diseases

2 with human CD55 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				protein-losing enteropathy IDs protein-losing enteropathy DOID:10611 MESH:D011504 OMIM:226300 UMLS_CUI:C0033680

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

2
Endonuclease-mediated

1
Radiation induced

1
Targeted

3
Genomic Mutations

3 involving Cd55b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

904
Tissues

84
cDNA Data

7
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

10
UniProt

5
CCDS

CCDS35699.1, CCDS83587.1

Ensembl

ENSMUSG00000026401 (Evidence)
NCBI Gene

13137

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026401	Ensembl Gene Model \| MGI Sequence Detail	34473	C57BL/6J	± kb
transcript	ENSMUST00000112488	Ensembl \| MGI Sequence Detail	1325	Not Applicable
polypeptide	ENSMUSP00000108107	Ensembl \| MGI Sequence Detail	400	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000006176 complement decay-accelerating factor transmembrane isoform

(term hierarchy)
InterPro Domains

IPR000436 Sushi/SCR/CCP domain

IPR035976 Sushi/SCR/CCP superfamily

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All nucleic 9

Genomic 1

cDNA 8

Microarray probesets 4

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MGD-MRK-28145, MGI:2138208

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:274872 Ingham NJ, et al., Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS Biol. 2019 Apr;17(4):e3000194

TSS for Cd55b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13497	Chr1:130350803-130350819 (-)	-65 bp
Tssr13496	Chr1:130350759-130350802 (-)	-35 bp
Tssr13495	Chr1:130350507-130350529 (-)	228 bp
Tssr13494	Chr1:130350484-130350496 (-)	256 bp
Tssr13493	Chr1:130350456-130350476 (-)	280 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23