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Lcp1 Gene Detail
Summary
  • Symbol
    Lcp1
  • Name
    lymphocyte cytosolic protein 1
  • Synonyms
    D14Ertd310e, L-fimbrin, L-plastin, Pls2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104808
    NCBI Gene: 18826
  • Alliance
    gene page
  • Transcription Start Sites
    62 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:75368545-75468282 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 39.63 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    702 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104808
 protein coding gene Chr14:75368541-75468282 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021567
 protein coding gene Chr14:69940159-70046416 (+)
A/J MGP_AJ_G0021525
 protein coding gene Chr14:68382461-68483259 (+)
AKR/J MGP_AKRJ_G0021502
 protein coding gene Chr14:70414150-70515236 (+)
BALB/cJ MGP_BALBcJ_G0021532
 protein coding gene Chr14:68184725-68284602 (+)
C3H/HeJ MGP_C3HHeJ_G0021309
 protein coding gene Chr14:70141603-70242324 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021972
 protein coding gene Chr14:73014072-73116110 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019510
 protein coding gene Chr14:66027447-66127702 (+)
CAST/EiJ MGP_CASTEiJ_G0020826
 protein coding gene Chr14:66808165-66911076 (+)
CBA/J MGP_CBAJ_G0021277
 protein coding gene Chr14:75345044-75452288 (+)
DBA/2J MGP_DBA2J_G0021400
 protein coding gene Chr14:67790743-67891465 (+)
FVB/NJ MGP_FVBNJ_G0021378
 protein coding gene Chr14:67120608-67220585 (+)
LP/J MGP_LPJ_G0021470
 protein coding gene Chr14:71100726-71206663 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021405
 protein coding gene Chr14:74123698-74242129 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021995
 protein coding gene Chr14:69703523-69808512 (+)
PWK/PhJ MGP_PWKPhJ_G0020569
 protein coding gene Chr14:64524848-64626276 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020405
 protein coding gene Chr14:65649815-65755131 (+)
WSB/EiJ MGP_WSBEiJ_G0020879
 protein coding gene Chr14:70033732-70138295 (+)



Homology
more
  • Human Ortholog
    LCP1, lymphocyte cytosolic protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCP1, lymphocyte cytosolic protein 1
  • Synonyms
    CP64, HEL-S-37, LC64P, LPL, L-PLASTIN, PLS2
  • Links
    NCBI Gene ID: 3936
    neXtProt AC: NX_P13796
    UniProt: P13796

  • Chr Location
    13q14.13; chr13:46125920-46211871 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LCP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased susceptibility to S. aureus infection, defective neutrophil killing of S. aureus, and impaired adhesion-dependent respiratory bursts in neutrophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    31
  • cDNA Data
    35
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18826 NCBI Gene Model | MGI Sequence Detail 99738 C57BL/6J ±  kb
    transcript NM_001424513 RefSeq | MGI Sequence Detail 4112 C57BL/6  
    polypeptide Q61233 UniProt | EBI | MGI Sequence Detail 627 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      cDNA 35
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-28102, MGI:1261889, MGI:2145820
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:289366 Ezzell RM, et al., Differential localization of villin and fimbrin during development of the mouse visceral endoderm and intestinal epithelium. Development. 1989 Jun;106(2):407-19
    • Latest
      J:345981 Lin X, et al., Expression of non-phosphorylatable S5A-L-plastin exerts phenotypes distinct from L-plastin deficiency during podosome formation and phagocytosis. Front Cell Dev Biol. 2023;11:1020091
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory