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Kcnj6 Gene Detail
Summary
  • Symbol
    Kcnj6
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 6
  • Synonyms
    GIRK2, KCNJ7, Kir3.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:104781
    NCBI Gene: 16522
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:94549495-94798560 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 55.44 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2175 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104781
 protein coding gene Chr16:94545839-94798719 (-)
129S1/SvImJ ENSMUSG00200016543
 protein coding gene Chr16:91484765-91732524 (-)
A/J ENSMUSG00195026888
 protein coding gene Chr16:91238806-91488199 (-)
AKR/J ENSMUSG00220016045
 protein coding gene Chr16:91481514-91729203 (-)
BALB/cJ ENSMUSG00180014891
 protein coding gene Chr16:91312957-91562328 (-)
C3H/HeJ ENSMUSG00175002723
 protein coding gene Chr16:91649863-91899221 (-)
C57BL/6NJ ENSMUSG00215012316
 protein coding gene Chr16:91441424-91690836 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020993
 protein coding gene Chr16:89341486-89595901 (-)
CAST/EiJ ENSTCUG00005019019
 protein coding gene Chr16:91043838-91300500 (-)
CBA/J ENSMUSG00210017796
 protein coding gene Chr16:91554861-91802596 (-)
DBA/2J ENSMUSG00185030466
 protein coding gene Chr16:91496783-91746167 (-)
FVB/NJ ENSMUSG00205015801
 protein coding gene Chr16:91273864-91521616 (-)
JF1/MsJ ENSUMUG00000016534
 protein coding gene Chr16:91630630-91880069 (-)
LP/J ENSMUSG00230025005
 protein coding gene Chr16:94031348-94279094 (-)
NOD/ShiLtJ ENSMUSG00190003661
 protein coding gene Chr16:91462769-91710491 (-)
NZO/HlLtJ ENSMUSG00225029728
 protein coding gene Chr16:97140546-97389654 (-)
PWK/PhJ ENSLUMG00010012414
 protein coding gene Chr16:91267761-91517859 (-)
SPRET/EiJ ENSMSPG00010020447
 protein coding gene Chr16:92392527-92640520 (-)
WSB/EiJ ENSIUOG00005018022
 protein coding gene Chr16:91408906-91658437 (-)



Homology
more
  • Human Ortholog
    KCNJ6, potassium inwardly rectifying channel subfamily J member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNJ6, potassium inwardly rectifying channel subfamily J member 6
  • Synonyms
    BIR1, GIRK-2, GIRK2, hiGIRK2, KATP-2, KATP2, KCNJ7, KIR3.2, KPLBS
  • Links
    NCBI Gene ID: 3763
    UniProt: P48051

  • Chr Location
    21q22.13; chr21:37607373-38121345 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCNJ6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    83 phenotypes from 4 alleles in 11 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    349 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
A spontaneous mutation exhibits small size, ataxia, hypotonia, high periweaning mortality, Purkinje cell defects, and male sterility. Homozygotes for a targeted null mutation exhibit increased susceptibility to spontaneous and drug-induced seizures.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1123
  • Tissues
    206
  • cDNA Data
    30
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043301 Ensembl Gene Model | MGI Sequence Detail 249066 C57BL/6J ±  kb
    transcript ENSMUST00000099508 Ensembl | MGI Sequence Detail 3097 Not Applicable  
    polypeptide ENSMUSP00000097108 Ensembl | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      Genomic 11
      cDNA 31
      Primer pair 14
      Other 1
      Antibodies 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-15467, MGD-MRK-28073
    References
    more
    • Summaries
      All 450
      Developmental Gene Expression 28
      Diseases 6
      Gene Ontology 17
      Phenotypes 349
    • Earliest
      J:5294 Rezai Z, et al., Abnormal rate of granule cell migration in the cerebellum of Weaver mutant mice. Dev Biol. 1972 Sep;29(1):17-26
    • Latest
      J:385727 Harada K, et al., Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome. Immunology. 2026 Mar;177(3):596-612
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory