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Adam5 Gene Detail
Summary
  • Symbol
    Adam5
  • Name
    a disintegrin and metallopeptidase domain 5
  • Synonyms
    tMDCII
  • Feature Type
    protein coding gene
  • IDs
    MGI:104730
    NCBI Gene: 11499
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:25217109-25314385 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 13.26 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    132 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104730
protein coding gene Chr8:25217109-25314385 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033474
protein coding gene Chr8:22731755-22808311 (-)
A/J MGP_AJ_G0033454
protein coding gene Chr8:21935959-22017163 (-)
AKR/J MGP_AKRJ_G0033379
protein coding gene Chr8:22659571-22733588 (-)
BALB/cJ MGP_BALBcJ_G0033450
protein coding gene Chr8:22088927-22165063 (-)
C3H/HeJ MGP_C3HHeJ_G0033164
protein coding gene Chr8:22850942-22933910 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033966
protein coding gene Chr8:23634644-23743000 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030916
protein coding gene Chr8:19243726-19313420 (-)
CAST/EiJ MGP_CASTEiJ_G0032490
protein coding gene Chr8:22275419-22357437 (-)
CBA/J MGP_CBAJ_G0033139
protein coding gene Chr8:24584674-24669613 (-)
DBA/2J MGP_DBA2J_G0033294
protein coding gene Chr8:21903784-21992598 (-)
FVB/NJ MGP_FVBNJ_G0033238
protein coding gene Chr8:21690534-21784364 (-)
LP/J MGP_LPJ_G0033383
protein coding gene Chr8:22722762-22801155 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033281
protein coding gene Chr8:24103636-24194450 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033985
protein coding gene Chr8:22577220-22667403 (-)
PWK/PhJ MGP_PWKPhJ_G0032201
protein coding gene Chr8:21510071-21586585 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032035
protein coding gene Chr8:21940055-22016351 (-)
WSB/EiJ MGP_WSBEiJ_G0032606
protein coding gene Chr8:22802419-22867762 (-)



Homology
more
  • Human Ortholog
    ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM5, ADAM metallopeptidase domain 5 (pseudogene)
  • Synonyms
    ADAM5P, TMDCII
  • Links
    NCBI Gene ID: 255926
    UniProt: Q6NVV9

  • Chr Location
    8p11.22; chr8:39314591-39417378 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11499 NCBI Gene Model | MGI Sequence Detail 97277 C57BL/6J ±  kb
    transcript NM_001272058 RefSeq | MGI Sequence Detail 2956 ZRU/MplStud  
    polypeptide Q3TTE0 UniProt | EBI | MGI Sequence Detail 751 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-27093
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:17855 Ballock RT, et al., Inhibition of the chondrocyte phenotype by retinoic acid involves upregulation of metalloprotease genes independent of TGF-beta. J Cell Physiol. 1994 May;159(2):340-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    05/21/2024
    MGI 6.23
    The Jackson Laboratory