T2 MGI Mouse Gene Detail - MGI:104658

Symbol

T2
Name

brachyury 2

Feature Type

protein coding gene
IDs

MGI:104658
NCBI Gene: 21331
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:8574824-8642345 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 4.92 cM
Mapping Data

3 experiments

SNPs within 2kb

467 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104658	protein coding gene	Chr17:8574590-8661323 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0015335	unclassified non-coding RNA gene	Chr17:5838624-5896825 (+)
A/J	MGP_AJ_G0015310	unclassified non-coding RNA gene	Chr17:5869238-5920060 (+)
AKR/J	MGP_AKRJ_G0015273	unclassified non-coding RNA gene	Chr17:5553773-5605777 (+)
BALB/cJ	MGP_BALBcJ_G0015273	unclassified non-coding RNA gene	Chr17:5668251-5718018 (+)
C3H/HeJ	MGP_C3HHeJ_G0015097	unclassified non-coding RNA gene	Chr17:5817542-5871417 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0015727	unclassified non-coding RNA gene	Chr17:6129474-6185724 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013469	unclassified non-coding RNA gene	Chr17:8448360-8497582 (-)
CAST/EiJ	MGP_CASTEiJ_G0014648	unclassified non-coding RNA gene	Chr17:5798975-5851867 (+)
CBA/J	MGP_CBAJ_G0015076	unclassified non-coding RNA gene	Chr17:6331639-6388000 (+)
DBA/2J	MGP_DBA2J_G0015171	unclassified non-coding RNA gene	Chr17:5534410-5585637 (+)
FVB/NJ	MGP_FVBNJ_G0015178	unclassified non-coding RNA gene	Chr17:5462982-5516051 (+)
LP/J	MGP_LPJ_G0015251	unclassified non-coding RNA gene	Chr17:5666354-5722835 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015204	unclassified non-coding RNA gene	Chr17:6074795-6128241 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0015767	unclassified non-coding RNA gene	Chr17:5825750-5883221 (+)
PWK/PhJ	MGP_PWKPhJ_G0014438	unclassified non-coding RNA gene	Chr17:5164277-5219774 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014225	unclassified non-coding RNA gene	Chr17:5092391-5149519 (+)
WSB/EiJ	MGP_WSBEiJ_G0014755	unclassified non-coding RNA gene	Chr17:6130987-6185014 (+)

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MGI Vertebrate Homology

T2 stringent orthology
1 mouse;1 rat
Gene Tree

T2

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References

6 with disease annotations

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Phenotype Summary

8 phenotypes from multigenic genotypes
334 phenotype references

All Mutations and Alleles

3
Gene trapped

1
Radiation induced

1
Transgenic

1
Genomic Mutations

1 involving T2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available

Homozygotes for mutations at this locus fail to form an organized caudal notochord and die as embryos. Heterozygotes exhibit an abnormal tail phenotype.

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbxt.2

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All Sequences

62
RefSeq

30
UniProt

4
CCDS

CCDS37434.1, CCDS88987.1

Ensembl

ENSMUSG00000058159 (Evidence)
NCBI Gene

21331

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058159	Ensembl Gene Model \| MGI Sequence Detail	67522	C57BL/6J	± kb
transcript	ENSMUST00000163578	Ensembl \| MGI Sequence Detail	1755	Not Applicable
polypeptide	ENSMUSP00000156321	Ensembl \| MGI Sequence Detail	393	Not Applicable

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UniProt

4 Sequences

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All nucleic 7

Genomic 2

cDNA 5

Microarray probesets 1

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MGD-MRK-26098

Summaries

All 343

Developmental Gene Expression 1

Diseases 6

Gene Ontology 1

Phenotypes 334
Earliest

J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
Latest

J:346702 Colombi I, et al., Heterogeneous subpopulations of GABA(A)R-responding neurons coexist across neuronal network scales and developmental stages in health and disease. iScience. 2024 Apr 19;27(4):109438

TSS for T2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142538	Chr17:8575050-8575063 (+)	233 bp
Tssr5001	Chr17:8590906-8590929 (+)	16,094 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23