T2 MGI Mouse Gene Detail - MGI:104658

Symbol

T2
Name

brachyury 2

Feature Type

protein coding gene
IDs

MGI:104658
NCBI Gene: 21331
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:8574824-8642345 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 4.92 cM
Mapping Data

3 experiments

SNPs within 2kb

1653 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_104658	protein coding gene	Chr17:8574590-8661323 (+)
129S1/SvImJ	ENSMUSG00200033144	protein coding gene	Chr17:4810308-4877480 (+)
A/J	ENSMUSG00195023006	protein coding gene	Chr17:5018412-5085819 (+)
AKR/J	ENSMUSG00220025512	protein coding gene	Chr17:5083465-5150983 (+)
BALB/cJ	ENSMUSG00180021576	protein coding gene	Chr17:4664632-4732038 (+)
C3H/HeJ	ENSMUSG00175031143	protein coding gene	Chr17:4808924-4876322 (+)
C57BL/6NJ	ENSMUSG00215025477	protein coding gene	Chr17:4817127-4884668 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013469	unclassified non-coding RNA gene	Chr17:8448360-8497582 (-)
CAST/EiJ	ENSTCUG00005021855	protein coding gene	Chr17:5056003-5123688 (+)
CBA/J	ENSMUSG00210034853	protein coding gene	Chr17:4475732-4543131 (+)
DBA/2J	ENSMUSG00185022140	protein coding gene	Chr17:5568377-5635776 (+)
FVB/NJ	ENSMUSG00205008376	protein coding gene	Chr17:4881531-4948926 (+)
JF1/MsJ	ENSUMUG00000016808	protein coding gene	Chr17:5169898-5237296 (+)
LP/J	ENSMUSG00230032099	protein coding gene	Chr17:7003796-7071301 (+)
NOD/ShiLtJ	ENSMUSG00190031589	protein coding gene	Chr17:5014134-5081524 (+)
NZO/HlLtJ	ENSMUSG00225028999	protein coding gene	Chr17:8924088-8991591 (+)
PWK/PhJ	ENSLUMG00010018448	protein coding gene	Chr17:4983566-5051021 (+)
SPRET/EiJ	ENSMSPG00010036698	protein coding gene	Chr17:9231503-9306389 (-)
WSB/EiJ	no annotation

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MGI Vertebrate Homology

T2 stringent orthology
1 mouse;1 rat
Gene Tree

T2

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References

6 with disease annotations

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Phenotype Summary

8 phenotypes from multigenic genotypes
377 phenotype references

All Mutations and Alleles

9
Endonuclease-mediated

6
Gene trapped

1
Radiation induced

1
Transgenic

1
Genomic Mutations

3 involving T2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available

Homozygotes for mutations at this locus fail to form an organized caudal notochord and die as embryos. Heterozygotes exhibit an abnormal tail phenotype.

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

597
cDNA Data

5
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbxt.2

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All Sequences

62
RefSeq

30
UniProt

4
CCDS

CCDS37434.1, CCDS88987.1

Ensembl

ENSMUSG00000058159 (Evidence)
NCBI Gene

21331

			Length	Strain/Species	Flank
genomic	ENSMUSG00000058159	Ensembl Gene Model \| MGI Sequence Detail	67522	C57BL/6J	± kb
transcript	ENSMUST00000163578	Ensembl \| MGI Sequence Detail	1755	Not Applicable
polypeptide	ENSMUSP00000156321	Ensembl \| MGI Sequence Detail	393	Not Applicable

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UniProt

4 Sequences
GlyGen

A0A338P791 1 site

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All nucleic 7

Genomic 2

cDNA 5

Microarray probesets 1

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MGD-MRK-26098

Summaries

All 387

Developmental Gene Expression 1

Diseases 6

Gene Ontology 1

Phenotypes 377
Earliest

J:30229 Davisson MT, et al., Segmental trisomy as a mouse model for Down syndrome. Prog Clin Biol Res. 1993;384:117-33
Latest

J:391449 Thibodeau J, et al., Loss of cystathionine-beta-synthase contributes to elevated OXPHOS, a vulnerability in Ara-C-resistant Myeloid Leukemia in Down syndrome. Biochem Pharmacol. 2026 Feb 13;247:117815

TSS for T2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142538	Chr17:8575050-8575063 (+)	233 bp
Tssr5001	Chr17:8590906-8590929 (+)	16,094 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29