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Ambn Gene Detail
Summary
  • Symbol
    Ambn
  • Name
    ameloblastin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104655
    NCBI Gene: 11698
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:88603850-88616390 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 43.63 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    278 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104655
 protein coding gene Chr5:88603850-88616390 (+)
129S1/SvImJ ENSMUSG00200009062
 protein coding gene Chr5:84332613-84345161 (+)
A/J ENSMUSG00195025590
 protein coding gene Chr5:83505502-83518041 (+)
AKR/J ENSMUSG00220011407
 protein coding gene Chr5:83648563-83661107 (+)
BALB/cJ ENSMUSG00180023562
 protein coding gene Chr5:83332179-83344723 (+)
C3H/HeJ ENSMUSG00175038971
 protein coding gene Chr5:85418564-85431116 (+)
C57BL/6NJ ENSMUSG00215027747
 protein coding gene Chr5:84198548-84211087 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027372
 protein coding gene Chr5:81734019-81746890 (+)
CAST/EiJ ENSTCUG00005032771
 protein coding gene Chr5:83146591-83159200 (+)
CBA/J ENSMUSG00210005763
 protein coding gene Chr5:84227402-84239933 (+)
DBA/2J ENSMUSG00185038470
 protein coding gene Chr5:86141814-86154363 (+)
FVB/NJ ENSMUSG00205018060
 protein coding gene Chr5:83043765-83056305 (+)
JF1/MsJ ENSUMUG00000000548
 protein coding gene Chr5:90505837-90518557 (+)
LP/J ENSMUSG00230001136
 protein coding gene Chr5:90859117-90871665 (+)
NOD/ShiLtJ ENSMUSG00190027239
 protein coding gene Chr5:83091370-83103912 (+)
NZO/HlLtJ ENSMUSG00225007882
 protein coding gene Chr5:96015427-96027963 (+)
PWK/PhJ ENSLUMG00010028740
 protein coding gene Chr5:83174524-83187310 (+)
SPRET/EiJ ENSMSPG00010030168
 protein coding gene Chr5:85574973-85588132 (+)
WSB/EiJ ENSIUOG00005025228
 protein coding gene Chr5:86131889-86144405 (+)



Homology
more
  • Human Ortholog
    AMBN, ameloblastin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AMBN, ameloblastin
  • Synonyms
    AI1F
  • Links
    NCBI Gene ID: 258
    UniProt: Q9NP70

  • Chr Location
    4q13.3; chr4:70592256-70607288 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ambn mouse models; 1 with human AMBN associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    3 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice lack enamel and display abnormal ameloblast and tooth morphology and an increased incidence of dental epithelium derived tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    768
  • Tissues
    59
  • cDNA Data
    19
  • Literature Summary
    52
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11698 NCBI Gene Model | MGI Sequence Detail 12541 C57BL/6J ±  kb
    transcript NM_001303431 RefSeq | MGI Sequence Detail 1919 Not Specified  
    polypeptide O55189 UniProt | EBI | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 21
      Primer pair 11
      Other 4
      Antibodies 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26095
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 52
      Diseases 1
      Gene Ontology 8
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:391144 Mizuta K, et al., Nephronectin promotes ameloblast differentiation through its RGD motif. Biochem Biophys Res Commun. 2026 Aug 6;832:154409
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory