About   Help   FAQ
Tff3 Gene Detail
Summary
  • Symbol
    Tff3
  • Name
    trefoil factor 3, intestinal
  • Synonyms
    ITF, mITF
  • Feature Type
    protein coding gene
  • IDs
    MGI:104638
    NCBI Gene: 21786
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
  • Candidate for QTL
    4 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:31344280-31348585 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    238 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104638
 protein coding gene Chr17:31344280-31348620 (-)
129S1/SvImJ ENSMUSG00200048050
 protein coding gene Chr17:27031636-27036049 (-)
A/J ENSMUSG00195051663
 protein coding gene Chr17:27962521-27966881 (-)
AKR/J ENSMUSG00220049748
 protein coding gene Chr17:26990590-26994935 (-)
BALB/cJ ENSMUSG00180039625
 protein coding gene Chr17:27307122-27311537 (-)
C3H/HeJ ENSMUSG00175051800
 protein coding gene Chr17:26871800-26876146 (-)
C57BL/6NJ ENSMUSG00215050127
 protein coding gene Chr17:26861679-26866021 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021360
 protein coding gene Chr17:26995105-26999598 (-)
CAST/EiJ ENSTCUG00005042038
 protein coding gene Chr17:27740084-27744512 (-)
CBA/J ENSMUSG00210050009
 protein coding gene Chr17:26698838-26703182 (-)
DBA/2J ENSMUSG00185041417
 protein coding gene Chr17:29317655-29322066 (-)
FVB/NJ ENSMUSG00205051709
 protein coding gene Chr17:27172500-27176873 (-)
JF1/MsJ ENSUMUG00000046773
 protein coding gene Chr17:28492207-28496602 (-)
LP/J ENSMUSG00230054594
 protein coding gene Chr17:30430187-30434597 (-)
NOD/ShiLtJ ENSMUSG00190043436
 protein coding gene Chr17:26813819-26818216 (-)
NZO/HlLtJ ENSMUSG00225050355
 protein coding gene Chr17:32406708-32411123 (-)
PWK/PhJ ENSLUMG00010053234
 protein coding gene Chr17:26297311-26301702 (-)
SPRET/EiJ ENSMSPG00010034667
 protein coding gene Chr17:27569674-27574021 (-)
WSB/EiJ ENSIUOG00005049768
 protein coding gene Chr17:27579822-27584166 (-)



Homology
more
  • Human Ortholog
    TFF3, trefoil factor 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TFF3, trefoil factor 3
  • Synonyms
    ITF, P1B, TFI
  • Links
    NCBI Gene ID: 7033
    UniProt: Q07654

  • Chr Location
    21q22.3; chr21:42311667-42315409 (-)  GRCh38
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in impaired intestinal mucosal healing and death from colitis after administration of dextran sulfate sodium. Mice show poor epithelial regeneration after injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1013
  • Tissues
    309
  • cDNA Data
    83
  • Literature Summary
    37
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21786 NCBI Gene Model | MGI Sequence Detail 4306 C57BL/6J ±  kb
    transcript NM_011575 RefSeq | MGI Sequence Detail 458 ZRU/MplStud  
    polypeptide Q62395 UniProt | EBI | MGI Sequence Detail 81 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 6
      cDNA 83
      Primer pair 6
      Other 2
      Antibodies 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-26075
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 37
      Diseases 3
      Gene Ontology 7
      Phenotypes 50
    • Earliest
      J:25263 Mashimo H, et al., Structure and expression of murine intestinal trefoil factor: high evolutionary conservation and postnatal expression. Biochem Biophys Res Commun. 1995 May 5;210(1):31-7
    • Latest
      J:374016 Mirzadzare N, et al., Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis. Gut Microbes. 2025 Dec;17(1):2538696
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory