About   Help   FAQ
Tle1 Gene Detail
Summary
  • Symbol
    Tle1
  • Name
    transducin-like enhancer of split 1
  • Synonyms
    C230057C06Rik, Estm14, Grg1, Tle4l
  • Feature Type
    protein coding gene
  • IDs
    MGI:104636
    NCBI Gene: 21885
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:72036042-72119130 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 36.06 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2772 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_104636
 protein coding gene Chr4:72028182-72124575 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028384
 protein coding gene Chr4:71326826-71411343 (-)
A/J MGP_AJ_G0028345
 protein coding gene Chr4:68901754-68985432 (-)
AKR/J MGP_AKRJ_G0028294
 protein coding gene Chr4:70696330-70779864 (-)
BALB/cJ MGP_BALBcJ_G0028365
 protein coding gene Chr4:69058941-69143072 (-)
C3H/HeJ MGP_C3HHeJ_G0028080
 protein coding gene Chr4:71235053-71318626 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028805
 protein coding gene Chr4:73877974-73961417 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026108
 protein coding gene Chr4:65522850-65606410 (-)
CAST/EiJ MGP_CASTEiJ_G0027522
 protein coding gene Chr4:69207216-69295426 (-)
CBA/J MGP_CBAJ_G0028049
 protein coding gene Chr4:76278860-76365686 (-)
DBA/2J MGP_DBA2J_G0028198
 protein coding gene Chr4:68650566-68738170 (-)
FVB/NJ MGP_FVBNJ_G0028164
 protein coding gene Chr4:67758191-67843968 (-)
LP/J MGP_LPJ_G0028297
 protein coding gene Chr4:71686218-71772224 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028193
 protein coding gene Chr4:80073539-80159044 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028841
 protein coding gene Chr4:70760103-70844267 (-)
PWK/PhJ MGP_PWKPhJ_G0027248
 protein coding gene Chr4:67103544-67188665 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027074
 protein coding gene Chr4:68274046-68358040 (-)
WSB/EiJ MGP_WSBEiJ_G0027598
 protein coding gene Chr4:70831440-70919910 (-)



Homology
more
  • Human Ortholog
    TLE1, TLE family member 1, transcriptional corepressor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLE1, TLE family member 1, transcriptional corepressor
  • Synonyms
    ESG, ESG1, GRG1, TLE-1
  • Links
    NCBI Gene ID: 7088
    UniProt: Q04724

  • Chr Location
    9q21.32; chr9:81583683-81689547 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1029
  • Tissues
    202
  • cDNA Data
    25
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008305 Ensembl Gene Model | MGI Sequence Detail 83089 C57BL/6J ±  kb
    transcript ENSMUST00000030095 Ensembl | MGI Sequence Detail 2569 Not Applicable  
    polypeptide ENSMUSP00000030095 Ensembl | MGI Sequence Detail 780 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 28
      Primer pair 4
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-26073, MGI:2178299, MGI:2444832
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 44
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:29516 Mallo M, et al., Protein characterization and targeted disruption of Grg, a mouse gene related to the groucho transcript of the Drosophila Enhancer of split complex. Dev Dyn. 1995 Nov;204(3):338-47
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory