Skp1 MGI Mouse Gene Detail - MGI:103575 - S-phase kinase-associated protein 1

Symbol

Skp1
Name

S-phase kinase-associated protein 1
Synonyms

2610043E24Rik, 2610206H23Rik, p19Skp1, Skp1a, Tceb1l

Feature Type

protein coding gene
IDs

MGI:103575
NCBI Gene: 21402
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr11:52122822-52137685 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 31.86 cM
Mapping Data

4 experiments

SNPs within 2kb

37 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103575	protein coding gene	Chr11:52121349-52137685 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018282	protein coding gene	Chr11:51537722-51552599 (+)
A/J	MGP_AJ_G0018251	protein coding gene	Chr11:49608622-49624013 (+)
AKR/J	MGP_AKRJ_G0018221	protein coding gene	Chr11:51209275-51224119 (+)
BALB/cJ	MGP_BALBcJ_G0018222	protein coding gene	Chr11:49935545-49950460 (+)
C3H/HeJ	MGP_C3HHeJ_G0018033	protein coding gene	Chr11:51189590-51204516 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018674	protein coding gene	Chr11:53102554-53118858 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016324	protein coding gene	Chr11:47114719-47129994 (+)
CAST/EiJ	MGP_CASTEiJ_G0017598	protein coding gene	Chr11:51198768-51214427 (+)
CBA/J	MGP_CBAJ_G0018008	protein coding gene	Chr11:55610837-55625058 (+)
DBA/2J	MGP_DBA2J_G0018118	protein coding gene	Chr11:49335548-49350321 (+)
FVB/NJ	MGP_FVBNJ_G0018110	protein coding gene	Chr11:49000327-49015561 (+)
LP/J	MGP_LPJ_G0018192	protein coding gene	Chr11:51956902-51970947 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018134	protein coding gene	Chr11:56964982-56980749 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018716	protein coding gene	Chr11:51258838-51273726 (+)
PWK/PhJ	MGP_PWKPhJ_G0017373	protein coding gene	Chr11:49831422-49847442 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017168	protein coding gene	Chr11:50994101-51009696 (+)
WSB/EiJ	MGP_WSBEiJ_G0017645	protein coding gene	Chr11:50878810-50894099 (+)

Human Ortholog

SKP1, S-phase kinase associated protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SKP1, S-phase kinase associated protein 1
Synonyms

EMC19, OCP2, OCP-II, p19A, SKP1A, TCEB1L
Links

HGNC:10899

NCBI Gene ID: 6500

neXtProt AC: NX_P63208

UniProt: P63208
Chr Location

5q31.1; chr5:134156391-134177033 (-) GRCh38.p7

Alliance of Genome Resources

Skp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SKP1
Protein SuperFamily

E3_ubiquit_lig_SCF_Skp
Gene Tree

Skp1

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

32
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

25
Targeted

2
Transgenic

1
Genomic Mutations

1 involving Skp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional alleles activated in germ cells exhibit impaired meiosis and loss of germ cells.

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All GO Annotations

41
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

796
Tissues

67
cDNA Data

324
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SKP1

Xenbase skp1

ZFIN skp1

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Skp1 interacts with 165 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

60
RefSeq

6
UniProt

6
CCDS

CCDS24669.1

Ensembl

ENSMUSG00000036309 (Evidence)
NCBI Gene

21402

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036309	Ensembl Gene Model \| MGI Sequence Detail	14864	C57BL/6J	± kb
transcript	ENSMUST00000037324	Ensembl \| MGI Sequence Detail	1440	Not Applicable
polypeptide	ENSMUSP00000038744	Ensembl \| MGI Sequence Detail	163	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000000045 S-phase kinase-associated protein 1A

(term hierarchy)
InterPro Domains

IPR011333 SKP1/BTB/POZ domain superfamily

IPR016072 SKP1 component, dimerisation

IPR016073 SKP1 component, POZ domain

IPR036296 SKP1-like, dimerisation domain superfamily

IPR016897 S-phase kinase-associated protein 1

IPR001232 S-phase kinase-associated protein 1-like

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All nucleic 328

cDNA 325

Primer pair 3

Microarray probesets 4

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MGD-MRK-24460, MGI:1917574, MGI:1923841

Summaries

All 83

Developmental Gene Expression 13

Gene Ontology 19

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:330827 Yoo D, et al., Little skate genome provides insights into genetic programs essential for limb-based locomotion. Elife. 2022 Oct 26;11:e78345

TSS for Skp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3491	Chr11:52121699-52121711 (+)	-1,117 bp
Tssr101319	Chr11:52122855-52122868 (+)	40 bp
Tssr101320	Chr11:52123002-52123007 (+)	183 bp
Tssr101321	Chr11:52123010-52123055 (+)	211 bp
Tssr101322	Chr11:52123064-52123083 (+)	252 bp
Tssr101323	Chr11:52123091-52123113 (+)	280 bp
Tssr101324	Chr11:52123133-52123142 (+)	316 bp
Tssr3492	Chr11:52132620-52132624 (+)	9,800 bp
Tssr101325	Chr11:52137014-52137035 (+)	14,203 bp
Tssr101326	Chr11:52137378-52137386 (+)	14,560 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 01/24/2023 MGI 6.22