Hoxb3os Gene Detail

Summary

• Symbol
  Hoxb3os
• Name
  homeobox B3 and homeobox B2, opposite strand
• Synonyms
  Gm11530

• Feature Type
  antisense lncRNA gene
  BioType Conflict
  
• IDs
  MGI:103211
  NCBI Gene: 102632302
• Alliance
  genome feature page
• Transcription Start Sites
  4 TSS

Location &
Maps

• Sequence Map
  Chr11:96233860-96244220 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 11, 59.85 cM

Strain
Comparison

• SNPs within 2kb
  192 from dbSNP Build 142
• Strain Annotations
  19

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103211	antisense lncRNA gene	Chr11:96233787-96245517 (-)
129S1/SvImJ	ENSMUSG00200053049	lncRNA gene	Chr11:93478178-93489895 (-)
A/J	ENSMUSG00195052335	lncRNA gene	Chr11:93199746-93211431 (-)
AKR/J	ENSMUSG00220051661	lncRNA gene	Chr11:93458816-93470503 (-)
BALB/cJ	ENSMUSG00180052423	lncRNA gene	Chr11:93463055-93474781 (-)
C3H/HeJ	ENSMUSG00175051817	lncRNA gene	Chr11:93458888-93470606 (-)
C57BL/6NJ	ENSMUSG00215054481	lncRNA gene	Chr11:93051354-93063071 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0002691	antisense lncRNA gene	Chr11:92114360-92125931 (-)
CAST/EiJ	ENSTCUG00005050692	lncRNA gene	Chr11:92902214-92913939 (-)
CBA/J	ENSMUSG00210053385	lncRNA gene	Chr11:93162175-93173859 (-)
DBA/2J	ENSMUSG00185052062	lncRNA gene	Chr11:93508736-93520455 (-)
FVB/NJ	ENSMUSG00205049523	lncRNA gene	Chr11:93365263-93376980 (-)
JF1/MsJ	ENSUMUG00000056357	lncRNA gene	Chr11:93814857-93826541 (-)
LP/J	ENSMUSG00230050972	lncRNA gene	Chr11:94561262-94572975 (-)
NOD/ShiLtJ	ENSMUSG00190052926	lncRNA gene	Chr11:93556682-93568401 (-)
NZO/HlLtJ	ENSMUSG00225052571	lncRNA gene	Chr11:96617023-96628740 (-)
PWK/PhJ	ENSLUMG00010051323	lncRNA gene	Chr11:93359847-93371526 (-)
SPRET/EiJ	ENSMSPG00010051004	lncRNA gene	Chr11:93862159-93873854 (-)
WSB/EiJ	ENSIUOG00005051387	lncRNA gene	Chr11:93304525-93316243 (-)

Homology

• Gene Tree
  Hoxb3os
  

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 1 allele in 1 genetic background
  2 phenotypes from multigenic genotypes
  17 phenotype references
  

• All Mutations and Alleles
  7
• Endonuclease-mediated
  1
• Gene trapped
  2
• Targeted
  4
• Genomic Mutations
  4 involving Hoxb3os
• Find Mice (IMSR)
  3 strains or lines available

Mice with a knock-out of isoform 1 exhibit increased cell proliferation in the kidney but normal kidney morphology and function.

Expression

• Assay Results
  658
• Tissues
  30
• cDNA Data
  1
• Literature Summary
  7

Images

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  45
• RefSeq
  1

• Ensembl
  ENSMUSG00000084844 (Evidence)
• NCBI Gene
  102632302

Representative Sequences			Length	Strain/Species
genomic	102632302	NCBI Gene Model | MGI Sequence Detail	10361	C57BL/6J
transcript	NR_155303	RefSeq | MGI Sequence Detail	685	ZRU/MplStud

Molecular
Reagents

• All nucleic 13

  Genomic 1

  cDNA 3

  Primer pair 6

  Other 3

  
  

  Microarray probesets 1

Other
Accession IDs

MGD-MRK-24079, MGI:3649348

References

• Summaries
  All 34

  Developmental Gene Expression 7

  Phenotypes 17
• Earliest
  J:15577 Swiatek PJ, et al., Perinatal lethality and defects in hindbrain development in mice homozygous for a targeted mutation of the zinc finger gene Krox20. Genes Dev. 1993 Nov;7(11):2071-84
• Latest
  J:345935 Weisser I, et al., Ablation of Long Noncoding RNA Hoxb3os Exacerbates Cystogenesis in Mouse Polycystic Kidney Disease. J Am Soc Nephrol. 2024 Jan 1;35(1):41-55

TSS for Hoxb3os:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110332	Chr11:96241014-96241025 (-)	3,200 bp
Tssr110331	Chr11:96240899-96240953 (-)	3,294 bp
Tssr110330	Chr11:96238172-96238185 (-)	6,041 bp
Tssr110329	Chr11:96238121-96238156 (-)	6,081 bp