Cish MGI Mouse Gene Detail - MGI:103159 - cytokine inducible SH2-containing protein

Symbol

Cish
Name

cytokine inducible SH2-containing protein
Synonyms

Cis, CIS1, cytokine-inducible SH2 protein, F23

Feature Type

protein coding gene
IDs

MGI:103159
NCBI Gene: 12700
Alliance

genome feature page
Transcription Start Sites

19 TSS

Sequence Map

Chr9:107173858-107179983 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 57.99 cM
Mapping Data

5 experiments

SNPs within 2kb

201 from dbSNP Build 142
Strain Annotations

31
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_103159	protein coding gene	Chr9:107173225-107179983 (+)
129S1/SvImJ	ENSMUSG00200039339	protein coding gene	Chr9:104366771-104372604 (+)
129S1/SvImJ	ENSMUSG00200039347	protein coding gene	Chr9:104371759-104372750 (+)
A/J	ENSMUSG00195036744	protein coding gene	Chr9:103590525-103591534 (+)
A/J	ENSMUSG00195036699	protein coding gene	Chr9:103585537-103591370 (+)
AKR/J	ENSMUSG00220021790	protein coding gene	Chr9:103980401-103981410 (+)
AKR/J	ENSMUSG00220021770	protein coding gene	Chr9:103975413-103981246 (+)
BALB/cJ	ENSMUSG00180026287	protein coding gene	Chr9:103906976-103907985 (+)
BALB/cJ	ENSMUSG00180026242	protein coding gene	Chr9:103901988-103907821 (+)
C3H/HeJ	ENSMUSG00175037313	protein coding gene	Chr9:104244319-104250152 (+)
C3H/HeJ	ENSMUSG00175037359	protein coding gene	Chr9:104249307-104250316 (+)
C57BL/6NJ	ENSMUSG00215029892	protein coding gene	Chr9:104223097-104228955 (+)
C57BL/6NJ	ENSMUSG00215029963	protein coding gene	Chr9:104228111-104229120 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032640	protein coding gene	Chr9:102620677-102627626 (+)
CAST/EiJ	ENSTCUG00005023856	protein coding gene	Chr9:103995279-104002038 (+)
CBA/J	ENSMUSG00210028988	protein coding gene	Chr9:104098260-104099269 (+)
CBA/J	ENSMUSG00210028959	protein coding gene	Chr9:104093252-104099104 (+)
DBA/2J	ENSMUSG00185030587	protein coding gene	Chr9:104263087-104264096 (+)
DBA/2J	ENSMUSG00185030551	protein coding gene	Chr9:104258069-104263931 (+)
FVB/NJ	ENSMUSG00205026435	protein coding gene	Chr9:104259989-104260998 (+)
FVB/NJ	ENSMUSG00205026337	protein coding gene	Chr9:104255001-104260834 (+)
JF1/MsJ	ENSUMUG00000052662	protein coding gene	Chr9:104075417-104081259 (+)
LP/J	ENSMUSG00230045981	protein coding gene	Chr9:104396360-104401256 (+)
LP/J	ENSMUSG00230046029	protein coding gene	Chr9:104400707-104401716 (+)
NOD/ShiLtJ	ENSMUSG00190042305	protein coding gene	Chr9:103897197-103898206 (+)
NOD/ShiLtJ	ENSMUSG00190042238	protein coding gene	Chr9:103892209-103898042 (+)
NZO/HlLtJ	ENSMUSG00225022514	protein coding gene	Chr9:104634817-104635826 (+)
NZO/HlLtJ	ENSMUSG00225022510	protein coding gene	Chr9:104630470-104635366 (+)
PWK/PhJ	ENSLUMG00010033051	protein coding gene	Chr9:104040460-104046312 (+)
SPRET/EiJ	ENSMSPG00010038674	protein coding gene	Chr9:105870060-105875581 (+)
WSB/EiJ	ENSIUOG00005046357	protein coding gene	Chr9:103338755-103344594 (+)

Human Ortholog

CISH, cytokine inducible SH2 containing protein

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CISH, cytokine inducible SH2 containing protein
Synonyms

BACTS2, CIS, CIS-1, G18, SOCS
Links

HGNC:1984

NCBI Gene ID: 1154

UniProt: Q9NSE2
Chr Location

3p21.2; chr3:50606456-50611774 (-) GRCh38

MGI Vertebrate Homology

Cish stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CISH
Gene Tree

Cish

Diseases

2 with human CISH associations

				Human Disease	Mouse Models
				malaria IDs malaria DOID:12365 DOID:12552 EFO:0001068 ICD10CM:B54 ICD9CM:084 ICD9CM:084.6 MESH:D008288 NCI:C34797 ORDO:673 UMLS_CUI:C0024530
				tuberculosis IDs tuberculosis DOID:399 DOID:10096 DOID:12688 DOID:12691 DOID:415 DOID:9901 DOID:9902 MESH:D014375 UMLS_CUI:C0041295

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

22 phenotypes from 3 alleles in 4 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

4
Gene trapped

2
Targeted

9
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit enhanced Th2 and Th9 differentiation and allergic airway inflammation.

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All GO Annotations

9
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

639
Tissues

20
cDNA Data

69
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cish

ZFIN cisha, cishb

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All Sequences

66
RefSeq

6
UniProt

6
CCDS

CCDS40761.1

Ensembl

ENSMUSG00000032578 (Evidence)
NCBI Gene

12700

			Length	Strain/Species	Flank
genomic	12700	NCBI Gene Model \| MGI Sequence Detail	6126	C57BL/6J	± kb
transcript	NM_009895	RefSeq \| MGI Sequence Detail	3014	ZRU/MplStud
polypeptide	Q62225	UniProt \| EBI \| MGI Sequence Detail	257	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000005503 cytokine-inducible SH2-containing protein

(term hierarchy)
InterPro Domains

IPR035887 CIS, SH2 domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001496 SOCS box domain

IPR036036 SOCS box-like domain superfamily
GlyGen

Q62225 1 site

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All nucleic 83

Genomic 6

cDNA 71

Primer pair 6

Microarray probesets 3

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MGD-MRK-24025, MGI:2143029

Summaries

All 80

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 24
Earliest

J:26494 Yoshimura A, et al., A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 1995 Jun 15;14(12):2816-26
Latest

J:379194 D'Amico S, et al., Loss of Snhg5 disrupts cell-cycle regulation without altering cystogenesis in a mouse model of polycystic kidney disease. Sci Rep. 2026 Jan 8;16(1):4869

TSS for Cish:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr86950	Chr9:107173098-107173109 (+)	-754 bp
Tssr86951	Chr9:107173127-107173134 (+)	-727 bp
Tssr86952	Chr9:107173409-107173420 (+)	-443 bp
Tssr86953	Chr9:107173422-107173434 (+)	-430 bp
Tssr86954	Chr9:107173881-107173936 (+)	51 bp
Tssr86955	Chr9:107174042-107174099 (+)	213 bp
Tssr86956	Chr9:107175555-107175570 (+)	1,705 bp
Tssr86957	Chr9:107175827-107175835 (+)	1,973 bp
Tssr86958	Chr9:107176351-107176355 (+)	2,495 bp
Tssr86959	Chr9:107176550-107176564 (+)	2,699 bp
Tssr86960	Chr9:107176610-107176624 (+)	2,759 bp
Tssr86961	Chr9:107177111-107177120 (+)	3,258 bp
Tssr86962	Chr9:107177144-107177154 (+)	3,291 bp
Tssr86963	Chr9:107177170-107177181 (+)	3,318 bp
Tssr86964	Chr9:107177199-107177218 (+)	3,351 bp
Tssr86965	Chr9:107177219-107177230 (+)	3,367 bp
Tssr86966	Chr9:107177239-107177246 (+)	3,385 bp
Tssr86967	Chr9:107177292-107177303 (+)	3,440 bp
Tssr86968	Chr9:107179037-107179042 (+)	5,182 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24