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Pltp Gene Detail
Summary
  • Symbol
    Pltp
  • Name
    phospholipid transfer protein
  • Synonyms
    Bpife, OD107
  • Feature Type
    protein coding gene
  • IDs
    MGI:103151
    NCBI Gene: 18830
  • Alliance
    gene page
  • Transcription Start Sites
    42 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:164681441-164699564 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 85.27 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    801 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103151
 protein coding gene Chr2:164681438-164699631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026880
 protein coding gene Chr2:170348501-170367675 (-)
A/J MGP_AJ_G0026847
 protein coding gene Chr2:163378248-163397544 (-)
AKR/J MGP_AKRJ_G0026818
 protein coding gene Chr2:168253506-168273144 (-)
BALB/cJ MGP_BALBcJ_G0026856
 protein coding gene Chr2:163745254-163763629 (-)
C3H/HeJ MGP_C3HHeJ_G0026598
 protein coding gene Chr2:168600963-168620129 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027303
 protein coding gene Chr2:175281046-175298848 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024674
 protein coding gene Chr2:156785182-156803284 (-)
CAST/EiJ MGP_CASTEiJ_G0026056
 protein coding gene Chr2:169015725-169034014 (-)
CBA/J MGP_CBAJ_G0026575
 protein coding gene Chr2:181640779-181662358 (-)
DBA/2J MGP_DBA2J_G0026713
 protein coding gene Chr2:162545298-162563198 (-)
FVB/NJ MGP_FVBNJ_G0026679
 protein coding gene Chr2:160966058-160984677 (-)
LP/J MGP_LPJ_G0026815
 protein coding gene Chr2:170406022-170424008 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026698
 protein coding gene Chr2:185198158-185216394 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027360
 protein coding gene Chr2:168140642-168161436 (-)
PWK/PhJ MGP_PWKPhJ_G0025793
 protein coding gene Chr2:162146504-162165421 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025594
 protein coding gene Chr2:167040748-167063321 (-)
WSB/EiJ MGP_WSBEiJ_G0026129
 protein coding gene Chr2:169020641-169040045 (-)



Homology
more
  • Human Ortholog
    PLTP, phospholipid transfer protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLTP, phospholipid transfer protein
  • Synonyms
    BPIFE, HDLCQ9
  • Links
    NCBI Gene ID: 5360
    UniProt: P55058

  • Chr Location
    20q13.12; chr20:45898620-45912155 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pltp mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have lower levels of circulating HDL and exhibit symptoms of dry eye syndrome such as corneal epithelial damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    31
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18830 NCBI Gene Model | MGI Sequence Detail 18124 C57BL/6J ±  kb
    transcript NM_001420693 RefSeq | MGI Sequence Detail 1912 ZRU/MplStud  
    polypeptide P55065 UniProt | EBI | MGI Sequence Detail 493 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000012888 phospholipid transfer protein
      (term hierarchy)
    • InterPro Domains
      IPR017943 Bactericidal permeability-increasing protein, alpha/beta domain superfamily
      IPR032942 BPI/LBP/Plunc family
      IPR030675 Lipid binding protein BPI/LBP
      IPR017954 Lipid-binding serum glycoprotein, conserved site
      IPR001124 Lipid-binding serum glycoprotein, C-terminal
      IPR017942 Lipid-binding serum glycoprotein, N-terminal
    • GlyGen
      P55065 9 sites, 5 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 3
      cDNA 11
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24017
    References
    more
    • Summaries
      All 104
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 3
      Phenotypes 48
    • Earliest
      J:27216 Jiang XC, et al., Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J Biol Chem. 1995 Jul 21;270(29):17133-8
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory