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Anapc1 Gene Detail
Summary
  • Symbol
    Anapc1
  • Name
    anaphase promoting complex subunit 1
  • Synonyms
    2610021O03Rik, Apc1, Mcpr, tsg24
  • Feature Type
    protein coding gene
  • IDs
    MGI:103097
    NCBI Gene: 17222
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:128452024-128529311 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 62.63 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    641 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103097
 protein coding gene Chr2:128452003-128529558 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026474
 protein coding gene Chr2:131954513-132040419 (-)
A/J MGP_AJ_G0026438
 protein coding gene Chr2:126612162-126691091 (-)
AKR/J MGP_AKRJ_G0026413
 protein coding gene Chr2:130210308-130288529 (-)
BALB/cJ MGP_BALBcJ_G0026450
 protein coding gene Chr2:126875652-126953357 (-)
C3H/HeJ MGP_C3HHeJ_G0026193
 protein coding gene Chr2:130717975-130801055 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026895
 protein coding gene Chr2:136079373-136160574 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024272
 protein coding gene Chr2:121437409-121517545 (-)
CAST/EiJ MGP_CASTEiJ_G0025654
 protein coding gene Chr2:130953525-131038247 (-)
CBA/J MGP_CBAJ_G0026173
 protein coding gene Chr2:141101137-141185408 (-)
DBA/2J MGP_DBA2J_G0026307
 protein coding gene Chr2:126003756-126080307 (-)
FVB/NJ MGP_FVBNJ_G0026271
 protein coding gene Chr2:124652250-124729450 (-)
LP/J MGP_LPJ_G0026412
 protein coding gene Chr2:132185304-132264179 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026291
 protein coding gene Chr2:145058054-145135942 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026950
 protein coding gene Chr2:130239280-130319340 (-)
PWK/PhJ MGP_PWKPhJ_G0025390
 protein coding gene Chr2:125576770-125653900 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025192
 protein coding gene Chr2:129350199-129427334 (-)
WSB/EiJ MGP_WSBEiJ_G0025728
 protein coding gene Chr2:131152476-131230805 (-)



Homology
more
  • Human Ortholog
    ANAPC1, anaphase promoting complex subunit 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANAPC1, anaphase promoting complex subunit 1
  • Synonyms
    APC1, MCPR, TSG24
  • Links
    NCBI Gene ID: 64682
    neXtProt AC: NX_Q9H1A4
    UniProt: Q9H1A4

  • Chr Location
    2q13; chr2:111611639-111884690 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ANAPC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    7
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014355 Ensembl Gene Model | MGI Sequence Detail 77288 C57BL/6J ±  kb
    transcript ENSMUST00000014499 Ensembl | MGI Sequence Detail 8942 Not Applicable  
    polypeptide ENSMUSP00000014499 Ensembl | MGI Sequence Detail 1944 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000004012 anaphase-promoting complex subunit 1
      (term hierarchy)
    • InterPro Domains
      IPR024990 Anaphase-promoting complex subunit 1
      IPR048971 Anaphase-promoting complex subunit 1, beta-sandwich domain
      IPR041221 Anaphase-promoting complex subunit 1, C-terminal
      IPR046794 Anaphase-promoting complex subunit 1, middle domain
      IPR049255 Anaphase-promoting complex subunit 1, N-terminal domain
      IPR011989 Armadillo-like helical
      IPR002015 Proteasome/cyclosome repeat
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 25

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-23961, MGI:1923795, MGI:2138834, MGI:2139095, MGI:2139376
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:320745 Ferguson CJ, et al., APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain. Mol Cell. 2022 Jan 6;82(1):90-105.e13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory