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Zp1 Gene Detail
Summary
  • Symbol
    Zp1
  • Name
    zona pellucida glycoprotein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103073
    NCBI Gene: 22786
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:10891660-10897965 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 7.36 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103073
 protein coding gene Chr19:10891651-10897996 (-)
129S1/SvImJ ENSMUSG00200046146
 protein coding gene Chr19:7570734-7577079 (-)
A/J ENSMUSG00195049717
 protein coding gene Chr19:7785744-7792089 (-)
AKR/J ENSMUSG00220033558
 protein coding gene Chr19:7691605-7697950 (-)
BALB/cJ ENSMUSG00180050496
 protein coding gene Chr19:8145459-8151805 (-)
C3H/HeJ ENSMUSG00175010504
 protein coding gene Chr19:7416437-7422775 (-)
C57BL/6NJ ENSMUSG00215040335
 protein coding gene Chr19:7488037-7494384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022705
 protein coding gene Chr19:8148491-8154844 (-)
CAST/EiJ ENSTCUG00005024862
 protein coding gene Chr19:7286180-7292518 (-)
CBA/J ENSMUSG00210040230
 protein coding gene Chr19:7615025-7621363 (-)
DBA/2J ENSMUSG00185050303
 protein coding gene Chr19:8024756-8031094 (-)
FVB/NJ ENSMUSG00205046917
 protein coding gene Chr19:7507788-7514140 (-)
JF1/MsJ ENSUMUG00000056007
 protein coding gene Chr19:8135047-8141405 (-)
LP/J ENSMUSG00230051888
 protein coding gene Chr19:8945362-8951707 (-)
NOD/ShiLtJ ENSMUSG00190021865
 protein coding gene Chr19:7243289-7249634 (-)
NZO/HlLtJ ENSMUSG00225044964
 protein coding gene Chr19:12654207-12660552 (-)
PWK/PhJ ENSLUMG00010007388
 protein coding gene Chr19:7533296-7539657 (-)
SPRET/EiJ ENSMSPG00010033305
 protein coding gene Chr19:7378434-7384732 (-)
WSB/EiJ ENSIUOG00005050494
 protein coding gene Chr19:7135328-7141685 (-)



Homology
more
  • Human Ortholog
    ZP1, zona pellucida glycoprotein 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZP1, zona pellucida glycoprotein 1
  • Synonyms
    HEL163, OOMD, OOMD1, OZEMA1, ZPB1
  • Links
    NCBI Gene ID: 22917
    UniProt: P60852

  • Chr Location
    11q12.2; chr11:60867542-60875693 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female homozygous mutants produce oocytes with abnormal zona pellucida. Fecunditiy is significantly reduced, probably due to precocious hatching.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    8
  • cDNA Data
    15
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22786 NCBI Gene Model | MGI Sequence Detail 6306 C57BL/6J ±  kb
    transcript NM_009580 RefSeq | MGI Sequence Detail 1925 Not Specified  
    polypeptide Q62005 UniProt | EBI | MGI Sequence Detail 623 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 15
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23937
    References
    more
    • Summaries
      All 82
      Developmental Gene Expression 11
      Gene Ontology 8
      Phenotypes 10
    • Earliest
      J:384087 Greve JM, et al., Mouse egg extracellular coat is a matrix of interconnected filaments possessing a structural repeat. J Mol Biol. 1985 Jan 20;181(2):253-64
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory