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Fcgrt Gene Detail
Summary
  • Symbol
    Fcgrt
  • Name
    Fc fragment of IgG receptor and transporter
  • Synonyms
    FcRn, neonatal Fc receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:103017
    NCBI Gene: 14132
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44742417-44753246 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.12 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103017
 protein coding gene Chr7:44742414-44753275 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032199
 protein coding gene Chr7:45324706-45336827 (-)
A/J MGP_AJ_G0032178
 protein coding gene Chr7:44465858-44476342 (-)
AKR/J MGP_AKRJ_G0032114
 protein coding gene Chr7:45692145-45704376 (-)
BALB/cJ MGP_BALBcJ_G0032190
 protein coding gene Chr7:44463742-44474455 (-)
C3H/HeJ MGP_C3HHeJ_G0031906
 protein coding gene Chr7:46190266-46201743 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032682
 protein coding gene Chr7:47595922-47606634 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029696
 protein coding gene Chr7:47027845-47038632 (-)
CAST/EiJ MGP_CASTEiJ_G0031234
 protein coding gene Chr7:37571932-37583966 (-)
CBA/J MGP_CBAJ_G0031870
 protein coding gene Chr7:49151255-49162101 (-)
DBA/2J MGP_DBA2J_G0032028
 protein coding gene Chr7:44134973-44146505 (-)
FVB/NJ MGP_FVBNJ_G0031979
 protein coding gene Chr7:43911357-43921902 (-)
LP/J MGP_LPJ_G0032106
 protein coding gene Chr7:46001689-46014115 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032016
 protein coding gene Chr7:47868709-47879403 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032698
 protein coding gene Chr7:44909457-44921318 (-)
PWK/PhJ MGP_PWKPhJ_G0030957
 protein coding gene Chr7:37499166-37510481 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030794
 protein coding gene Chr7:32920161-32931462 (-)
WSB/EiJ MGP_WSBEiJ_G0031351
 protein coding gene Chr7:45397909-45408899 (-)



Homology
more
  • Human Ortholog
    FCGRT, Fc gamma receptor and transporter
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FCGRT, Fc gamma receptor and transporter
  • Synonyms
    alpha-chain, FcgammaRn, FCRN
  • Links
    NCBI Gene ID: 2217
    neXtProt AC: NX_P55899
    UniProt: P55899

  • Chr Location
    19q13.33; chr19:49506816-49526428 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in defective perinatal transport of maternal IgG, increased clearance of IgG, and diminished IgG antibody response after immunization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    42
  • cDNA Data
    156
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14132 NCBI Gene Model | MGI Sequence Detail 10830 C57BL/6J ±  kb
    transcript NM_001357117 RefSeq | MGI Sequence Detail 1750 ZRU/MplStud  
    polypeptide Q61559 UniProt | EBI | MGI Sequence Detail 365 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000007435 IgG receptor FcRn large subunit p51
      (term hierarchy)
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
      IPR011161 MHC class I-like antigen recognition-like
      IPR037055 MHC class I-like antigen recognition-like superfamily
    Molecular
    Reagents
    less
    • All nucleic 159
      cDNA 156
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-23854
    References
    more
    • Summaries
      All 143
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 89
    • Earliest
      J:15612 Ahouse JJ, et al., Mouse MHC class I-like Fc receptor encoded outside the MHC. J Immunol. 1993 Dec 1;151(11):6076-88
    • Latest
      J:345543 Haddad G, et al., Knockout of the neonatal Fc receptor alters immune complex trafficking and lysosomal function in cultured podocytes. PLoS One. 2023;18(4):e0284636
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory