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Inmt Gene Detail
Summary
  • Symbol
    Inmt
  • Name
    indolethylamine N-methyltransferase
  • Synonyms
    Temt
  • Feature Type
    protein coding gene
  • IDs
    MGI:102963
    NCBI Gene: 21743
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:55147612-55151975 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 27.38 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    264 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102963
 protein coding gene Chr6:55147611-55152028 (-)
129S1/SvImJ ENSMUSG00200005763
 protein coding gene Chr6:52124576-52129027 (-)
A/J ENSMUSG00195032419
 protein coding gene Chr6:51861735-51866189 (-)
AKR/J ENSMUSG00220005606
 protein coding gene Chr6:51558169-51562624 (-)
BALB/cJ ENSMUSG00180009991
 protein coding gene Chr6:52155671-52160124 (-)
C3H/HeJ ENSMUSG00175035802
 protein coding gene Chr6:51916811-51921264 (-)
C57BL/6NJ ENSMUSG00215021286
 protein coding gene Chr6:52132694-52137111 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028412
 protein coding gene Chr6:49646075-49650521 (-)
CAST/EiJ ENSTCUG00005039030
 protein coding gene Chr6:51392631-51397128 (-)
CBA/J ENSMUSG00210030067
 protein coding gene Chr6:51961188-51965637 (-)
DBA/2J ENSMUSG00185017403
 protein coding gene Chr6:52540737-52545189 (-)
FVB/NJ ENSMUSG00205027631
 protein coding gene Chr6:52190696-52195149 (-)
JF1/MsJ ENSUMUG00000034181
 protein coding gene Chr6:51925733-51930211 (-)
LP/J ENSMUSG00230011915
 protein coding gene Chr6:53621608-53626059 (-)
NOD/ShiLtJ ENSMUSG00190008716
 protein coding gene Chr6:51872319-51876770 (-)
NZO/HlLtJ ENSMUSG00225013533
 protein coding gene Chr6:55613211-55617662 (-)
PWK/PhJ ENSLUMG00010017042
 protein coding gene Chr6:51666605-51671082 (-)
SPRET/EiJ ENSMSPG00010008169
 protein coding gene Chr6:52270632-52275055 (-)
WSB/EiJ ENSIUOG00005019963
 protein coding gene Chr6:52224311-52228746 (-)



Homology
more
  • Human Ortholog
    INMT, indolethylamine N-methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INMT, indolethylamine N-methyltransferase
  • Synonyms
    TEMT
  • Links
    NCBI Gene ID: 11185
    UniProt: O95050

  • Chr Location
    7p14.3; chr7:30697985-30757602 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    694
  • Tissues
    96
  • cDNA Data
    137
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21743 NCBI Gene Model | MGI Sequence Detail 4364 C57BL/6J ±  kb
    transcript NM_009349 RefSeq | MGI Sequence Detail 1023 C57BL/6  
    polypeptide P40936 UniProt | EBI | MGI Sequence Detail 264 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 138
      cDNA 137
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-23800
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 10
    • Earliest
      J:26180 Mozier NM, et al., S-adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism. J Biol Chem. 1988 Apr 5;263(10):4527-31
    • Latest
      J:376347 Hatzipantelis CJ, et al., Indolethylamine N-Methyltransferase Deletion Impacts Mouse Behavior without Disrupting Endogenous Psychedelic Tryptamine Production. ACS Chem Neurosci. 2025 Oct 15;16(20):4011-4024
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory