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Sult1a1 Gene Detail
Summary
  • Symbol
    Sult1a1
  • Name
    sulfotransferase family 1A, phenol-preferring, member 1
  • Synonyms
    PST, Stp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:102896
    NCBI Gene: 20887
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126272037-126275604 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • SNPs within 2kb
    129 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102896
 protein coding gene Chr7:126272037-126289615 (-)
129S1/SvImJ ENSMUSG00200023190
 protein coding gene Chr7:112777212-112780779 (-)
A/J ENSMUSG00195037560
 protein coding gene Chr7:117299423-117302990 (-)
AKR/J ENSMUSG00220018743
 protein coding gene Chr7:110726656-110730224 (-)
BALB/cJ ENSMUSG00180013294
 protein coding gene Chr7:113967314-113970882 (-)
C3H/HeJ ENSMUSG00175015331
 protein coding gene Chr7:114700083-114703650 (-)
C57BL/6NJ ENSMUSG00215025419
 protein coding gene Chr7:113980025-113983592 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030457
 protein coding gene Chr7:128681278-128684776 (-)
CAST/EiJ ENSTCUG00005047766
 protein coding gene Chr7:117197205-117200763 (-)
CBA/J ENSMUSG00210022584
 protein coding gene Chr7:114461166-114464733 (-)
DBA/2J ENSMUSG00185046680
 protein coding gene Chr7:118774013-118777580 (-)
FVB/NJ ENSMUSG00205039647
 protein coding gene Chr7:114413377-114416944 (-)
JF1/MsJ ENSUMUG00000030313
 protein coding gene Chr7:123827315-123830900 (-)
LP/J ENSMUSG00230053079
 protein coding gene Chr7:124877193-124880760 (-)
NOD/ShiLtJ ENSMUSG00190018236
 protein coding gene Chr7:114620402-114623969 (-)
NZO/HlLtJ ENSMUSG00225012244
 protein coding gene Chr7:123113366-123116932 (-)
PWK/PhJ ENSLUMG00010041272
 protein coding gene Chr7:112967484-112971051 (-)
SPRET/EiJ ENSMSPG00010012088
 protein coding gene Chr7:114234918-114238478 (-)
WSB/EiJ ENSIUOG00005026800
 protein coding gene Chr7:115322563-115326130 (-)



Homology
more
  • Human Ortholog
    SULT1A1, sulfotransferase family 1A member 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SULT1A1, sulfotransferase family 1A member 1
  • Synonyms
    HAST1/HAST2, P-PST, P-PST 1, PST, ST1A1, ST1A3, STP, STP1, ts-PST, TSPST1
  • Links
    NCBI Gene ID: 6817
    UniProt: P50225

  • Chr Location
    16p11.2; chr16:28605008-28623375 (-)  GRCh38
  • Human Ortholog
    SULT1A2, sulfotransferase family 1A member 2
  • Synonyms
    HAST4, P-PST, P-PST 2, ST1A2, STP2, TSPST2
  • Links
    NCBI Gene ID: 6799
    UniProt: P50226

  • Chr Location
    16p11.2; chr16:28591790-28599913 (-)  GRCh38
  • Human Ortholog
    SULT1A3, sulfotransferase family 1A member 3
  • Synonyms
    HAST, HAST3, M-PST, ST1A3, ST1A3/ST1A4, ST1A4, ST1A5, STM, TL-PST
  • Links
    NCBI Gene ID: 6818
    UniProt: P0DMM9

  • Chr Location
    16p11.2; chr16:30198059-30204324 (+)  GRCh38
  • Human Ortholog
    SULT1A4, sulfotransferase family 1A member 4
  • Synonyms
    HAST3, M-PST, ST1A3, ST1A3/ST1A4, ST1A4, STM, TL-PST
  • Links
    NCBI Gene ID: 445329
    UniProt: P0DMM9, P0DMN0

  • Chr Location
    chr16:29458993-29464966 (+)  GRCh38
Human Diseases
more
  • Diseases
    10 with human SULT1A1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decrease hepatic DNA adduct formation induced by methyleugenol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    692
  • Tissues
    95
  • cDNA Data
    54
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030711 Ensembl Gene Model | MGI Sequence Detail 3568 C57BL/6J ±  kb
    transcript ENSMUST00000106373 Ensembl | MGI Sequence Detail 1289 Not Applicable  
    polypeptide ENSMUSP00000101981 Ensembl | MGI Sequence Detail 298 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      cDNA 56

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14633, MGD-MRK-23730, MGI:2141894
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 3
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:2300 Charles CH, et al., cDNA sequence of a growth factor-inducible immediate early gene and characterization of its encoded protein. Oncogene. 1992 Jan;7(1):187-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory