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Gng2 Gene Detail
Summary
  • Symbol
    Gng2
  • Name
    guanine nucleotide binding protein (G protein), gamma 2
  • Synonyms
    1110003P13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:102705
    NCBI Gene: 14702
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:19922627-20027695 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 11.17 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    456 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102705
 protein coding gene Chr14:19922626-20027893 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021026
 protein coding gene Chr14:12590859-12711198 (-)
A/J MGP_AJ_G0020975
 protein coding gene Chr14:12302266-12421700 (-)
AKR/J MGP_AKRJ_G0020952
 protein coding gene Chr14:12812582-12930666 (-)
BALB/cJ MGP_BALBcJ_G0020978
 protein coding gene Chr14:12433461-12541667 (-)
C3H/HeJ MGP_C3HHeJ_G0020762
 protein coding gene Chr14:12743308-12867445 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021411
 protein coding gene Chr14:13102521-13216555 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018979
 protein coding gene Chr14:12643605-12748634 (-)
CAST/EiJ MGP_CASTEiJ_G0020286
 protein coding gene Chr14:12501337-12615971 (-)
CBA/J MGP_CBAJ_G0020728
 protein coding gene Chr14:13732815-13868354 (-)
DBA/2J MGP_DBA2J_G0020851
 protein coding gene Chr14:12142223-12256516 (-)
FVB/NJ MGP_FVBNJ_G0020834
 protein coding gene Chr14:12048065-12156718 (-)
LP/J MGP_LPJ_G0020927
 protein coding gene Chr14:12810264-12927841 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020860
 protein coding gene Chr14:13526741-13668170 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021444
 protein coding gene Chr14:12620113-12727166 (-)
PWK/PhJ MGP_PWKPhJ_G0020035
 protein coding gene Chr14:11668674-11794432 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019857
 protein coding gene Chr14:12374773-12491725 (-)
WSB/EiJ MGP_WSBEiJ_G0020342
 protein coding gene Chr14:12594830-12711486 (-)



Homology
more
  • Human Ortholog
    GNG2, G protein subunit gamma 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNG2, G protein subunit gamma 2
  • Synonyms
    HG3F1
  • Links
    NCBI Gene ID: 54331
    neXtProt AC: NX_P59768
    UniProt: P59768

  • Chr Location
    14q22.1; chr14:51826174-51979342 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Mice homozygous for a knock-out allele exhibit reduced vomeronasal basal neurons, reduced posterior glomerular layer of the accessory olfactory bulb and decreased aggression towards male mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    837
  • Tissues
    56
  • cDNA Data
    85
  • Literature Summary
    8
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043004 Ensembl Gene Model | MGI Sequence Detail 105069 C57BL/6J ±  kb
transcript ENSMUST00000161247 Ensembl | MGI Sequence Detail 419 Not Applicable  
polypeptide ENSMUSP00000124725 Ensembl | MGI Sequence Detail 71 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    Genomic 1
    cDNA 85
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-19609, MGI:1923542
References
more
  • Summaries
    All 48
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:14624 Hurley JB, et al., Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Proc Natl Acad Sci U S A. 1984 Nov;81(22):6948-52
  • Latest
    J:345930 Luo VM, et al., The Deubiquitylase Otub1 Regulates the Chemotactic Response of Splenic B Cells by Modulating the Stability of the gamma-Subunit Gng2. Mol Cell Biol. 2024 Jan;44(1):1-16
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory