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Grb7 Gene Detail
Summary
  • Symbol
    Grb7
  • Name
    growth factor receptor bound protein 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:102683
    NCBI Gene: 14786
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98337660-98346199 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102683
protein coding gene Chr11:98337220-98346199 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019061
protein coding gene Chr11:100995036-101005693 (+)
A/J MGP_AJ_G0019029
protein coding gene Chr11:96793206-96801955 (+)
AKR/J MGP_AKRJ_G0018999
protein coding gene Chr11:99792599-99802352 (+)
BALB/cJ MGP_BALBcJ_G0019002
protein coding gene Chr11:97286529-97295506 (+)
C3H/HeJ MGP_C3HHeJ_G0018816
protein coding gene Chr11:99925553-99935220 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019455
protein coding gene Chr11:104080592-104089985 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017086
protein coding gene Chr11:94231690-94240670 (+)
CAST/EiJ MGP_CASTEiJ_G0018370
protein coding gene Chr11:100805337-100822917 (+)
CBA/J MGP_CBAJ_G0018787
protein coding gene Chr11:108392950-108409292 (+)
DBA/2J MGP_DBA2J_G0018895
protein coding gene Chr11:96335617-96344438 (+)
FVB/NJ MGP_FVBNJ_G0018884
protein coding gene Chr11:95844761-95853635 (+)
LP/J MGP_LPJ_G0018965
protein coding gene Chr11:101468944-101479809 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018911
protein coding gene Chr11:108182168-108191139 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019495
protein coding gene Chr11:100122838-100133138 (+)
PWK/PhJ MGP_PWKPhJ_G0018142
protein coding gene Chr11:97343644-97352645 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017932
protein coding gene Chr11:99825061-99834016 (+)
WSB/EiJ MGP_WSBEiJ_G0018420
protein coding gene Chr11:100037788-100046774 (+)



Homology
more
  • Human Ortholog
    GRB7, growth factor receptor bound protein 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRB7, growth factor receptor bound protein 7
  • Links
    NCBI Gene ID: 2886
    neXtProt AC: NX_Q14451
    UniProt: Q14451

  • Chr Location
    17q12; chr17:39737927-39747291 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human GRB7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and survive to adulthood with no overt abnormalities. However, litters born to knockout females fail to thrive to weaning age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14786 NCBI Gene Model | MGI Sequence Detail 8540 C57BL/6J ±  kb
    transcript NM_010346 RefSeq | MGI Sequence Detail 2413 ZRU/MplStud  
    polypeptide Q03160 UniProt | EBI | MGI Sequence Detail 535 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 116
      cDNA 113
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19586
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:39581 Margolis B, et al., High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):8894-8
    • Latest
      J:347671 Vermehren-Schmaedick A, et al., Grb7 Ablation in Mice Improved Glycemic Control, Enhanced Insulin Signaling, and Increased Abdominal fat Mass in Females. Endocrinology. 2024 Mar 29;165(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/05/2024
    MGI 6.24
    The Jackson Laboratory