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Myh11 Gene Detail
Summary
  • Symbol
    Myh11
  • Name
    myosin, heavy polypeptide 11, smooth muscle
  • Synonyms
    SM1, SM2, smMHC
  • Feature Type
    protein coding gene
  • IDs
    MGI:102643
    NCBI Gene: 17880
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
  • Regulated by
    Rr278 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr16:14012392-14109227 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 9.71 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2840 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102643
 protein coding gene Chr16:14012392-14109236 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022543
 protein coding gene Chr16:11242829-11343478 (-)
A/J MGP_AJ_G0022505
 protein coding gene Chr16:10604147-10702296 (-)
AKR/J MGP_AKRJ_G0022481
 protein coding gene Chr16:11074490-11171424 (-)
BALB/cJ MGP_BALBcJ_G0022509
 protein coding gene Chr16:10780451-10878474 (-)
C3H/HeJ MGP_C3HHeJ_G0022276
 protein coding gene Chr16:11172186-11274232 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022958
 protein coding gene Chr16:11392836-11490775 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020478
 protein coding gene Chr16:10696807-10795631 (-)
CAST/EiJ MGP_CASTEiJ_G0021803
 protein coding gene Chr16:11192787-11301869 (-)
CBA/J MGP_CBAJ_G0022245
 protein coding gene Chr16:11943450-12043022 (-)
DBA/2J MGP_DBA2J_G0022376
 protein coding gene Chr16:10605633-10703048 (-)
FVB/NJ MGP_FVBNJ_G0022352
 protein coding gene Chr16:10587871-10685112 (-)
LP/J MGP_LPJ_G0022444
 protein coding gene Chr16:11125030-11230442 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022374
 protein coding gene Chr16:11560747-11664259 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022971
 protein coding gene Chr16:11048103-11148964 (-)
PWK/PhJ MGP_PWKPhJ_G0021545
 protein coding gene Chr16:10860983-10960543 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021374
 protein coding gene Chr16:11036069-11137794 (-)
WSB/EiJ MGP_WSBEiJ_G0021851
 protein coding gene Chr16:11062159-11161278 (-)



Homology
more
  • Human Ortholog
    MYH11, myosin heavy chain 11
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYH11, myosin heavy chain 11
  • Synonyms
    AAT4, FAA4, SMHC, SMMHC, SMMS-1, VSCM2
  • Links
    NCBI Gene ID: 4629
    UniProt: P35749

  • Chr Location
    16p13.11; chr16:15703135-15858438 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human MYH11 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 5 alleles in 4 genetic backgrounds
    2 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have impaired smooth muscle contractility. They are incapable of urinating, exhibit dilative cardiomyopathy, are growth retarded, and die within 3 days of birth.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1315
  • Tissues
    253
  • cDNA Data
    71
  • Literature Summary
    143
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17880 NCBI Gene Model | MGI Sequence Detail 96836 C57BL/6J ±  kb
    transcript NM_001402796 RefSeq | MGI Sequence Detail 6603 ZRU/MplStud  
    polypeptide O08638 UniProt | EBI | MGI Sequence Detail 1972 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 91
      cDNA 71
      Primer pair 13
      Other 7

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-19534, MGI:2139931
    References
    more
    • Summaries
      All 215
      Developmental Gene Expression 143
      Gene Ontology 6
      Phenotypes 26
    • Earliest
      J:4725 Matsuoka R, et al., Human smooth muscle myosin heavy chain gene mapped to chromosomal region 16q12. Am J Med Genet. 1993 Apr 1;46(1):61-7
    • Latest
      J:362939 Kwartler CS, et al., Inducing hypertension in Myh11 (R247C/R247C) mice triggers aortic dissections with increased focal adhesion kinase signaling. Front Cardiovasc Med. 2025;12:1492768
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory