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Pou4f3 Gene Detail
Summary
  • Symbol
    Pou4f3
  • Name
    POU domain, class 4, transcription factor 3
  • Synonyms
    Brn-3.1, Brn3.1, Brn3c
  • Feature Type
    protein coding gene
  • IDs
    MGI:102523
    NCBI Gene: 18998
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:42527662-42529158 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 22.58 cM, cytoband B3-E1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    82 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_102523
 protein coding gene Chr18:42527604-42530314 (+)
129S1/SvImJ ENSMUSG00200042374
 protein coding gene Chr18:39554178-39556888 (+)
A/J ENSMUSG00195036804
 protein coding gene Chr18:39709089-39711794 (+)
AKR/J ENSMUSG00220017169
 protein coding gene Chr18:39673511-39676227 (+)
BALB/cJ ENSMUSG00180015519
 protein coding gene Chr18:40154516-40157223 (+)
C3H/HeJ ENSMUSG00175038790
 protein coding gene Chr18:39655625-39658334 (+)
C57BL/6NJ ENSMUSG00215014469
 protein coding gene Chr18:39405232-39407944 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022227
 protein coding gene Chr18:39435408-39438115 (+)
CAST/EiJ ENSTCUG00005023161
 protein coding gene Chr18:39248975-39251705 (+)
CBA/J ENSMUSG00210019989
 protein coding gene Chr18:39720248-39722959 (+)
DBA/2J ENSMUSG00185018080
 protein coding gene Chr18:39629079-39631790 (+)
FVB/NJ ENSMUSG00205025702
 protein coding gene Chr18:39287939-39290651 (+)
JF1/MsJ ENSUMUG00000029290
 protein coding gene Chr18:39760180-39762907 (+)
LP/J ENSMUSG00230025575
 protein coding gene Chr18:41744695-41747405 (+)
NOD/ShiLtJ ENSMUSG00190020109
 protein coding gene Chr18:39420812-39423525 (+)
NZO/HlLtJ ENSMUSG00225026740
 protein coding gene Chr18:41629722-41632438 (+)
PWK/PhJ ENSLUMG00010010640
 protein coding gene Chr18:39891683-39894394 (+)
SPRET/EiJ ENSMSPG00010016965
 protein coding gene Chr18:40019402-40022115 (+)
WSB/EiJ ENSIUOG00005007022
 protein coding gene Chr18:39378654-39381359 (+)



Homology
more
  • Human Ortholog
    POU4F3, POU class 4 homeobox 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POU4F3, POU class 4 homeobox 3
  • Synonyms
    BRN3C, DFNA15, DFNA42, DFNA52
  • Links
    NCBI Gene ID: 5459
    UniProt: Q15319

  • Chr Location
    5q32; chr5:146338648-146341728 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pou4f3 mouse models; 1 with human POU4F3 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 7 alleles in 10 genetic backgrounds
    32 phenotypes from multigenic genotypes
    5 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with mutations in this gene show variable hearing and vestibular defects with cochlear hair cell defects in many cases.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    125
  • cDNA Data
    10
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18998 NCBI Gene Model | MGI Sequence Detail 1497 C57BL/6J ±  kb
    transcript NM_138945 RefSeq | MGI Sequence Detail 1146 ZRU/MplStud  
    polypeptide Q63955 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 7
      cDNA 11
      Primer pair 6
      Other 5
      Antibodies 6

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1632, MGD-MRK-19367, MGI:1342649
    References
    more
    • Summaries
      All 166
      Developmental Gene Expression 57
      Diseases 2
      Gene Ontology 17
      Phenotypes 67
    • Earliest
      J:16381 Theil T, et al., Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 1993 Dec 25;21(25):5921-9
    • Latest
      J:381018 Han J, et al., Locomotion-induced neural activity independent of auditory feedback in the mouse inferior colliculus. iScience. 2026 Mar 20;29(3):115057
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    09/15/2026
    MGI 6.29     		The Jackson Laboratory