Ptpn14 MGI Mouse Gene Detail - MGI:102467 - protein tyrosine phosphatase, non-receptor type 14

Symbol

Ptpn14
Name

protein tyrosine phosphatase, non-receptor type 14
Synonyms

C130080N23Rik, OTTMUSG00000022087, PTP36

Feature Type

protein coding gene
IDs

MGI:102467
NCBI Gene: 19250
Alliance

genome feature page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:189460465-189608892 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 95.03 cM
Mapping Data

4 experiments

SNPs within 2kb

4527 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102467	protein coding gene	Chr1:189460417-189608892 (+)
129S1/SvImJ	ENSMUSG00200003616	protein coding gene	Chr1:187227965-187376522 (+)
A/J	ENSMUSG00195007625	protein coding gene	Chr1:186804914-186956554 (+)
AKR/J	ENSMUSG00220004913	protein coding gene	Chr1:186052273-186205942 (+)
BALB/cJ	ENSMUSG00180017321	protein coding gene	Chr1:186873629-187022179 (+)
C3H/HeJ	ENSMUSG00175020504	protein coding gene	Chr1:187058498-187210127 (+)
C57BL/6NJ	ENSMUSG00215012982	protein coding gene	Chr1:186279784-186428231 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015036	protein coding gene	Chr1:179531892-179681126 (+)
CAST/EiJ	ENSTCUG00005002030	protein coding gene	Chr1:184840983-184989107 (+)
CBA/J	ENSMUSG00210003298	protein coding gene	Chr1:186726084-186877487 (+)
DBA/2J	ENSMUSG00185034218	protein coding gene	Chr1:191339229-191490643 (+)
FVB/NJ	ENSMUSG00205003431	protein coding gene	Chr1:185725404-185873896 (+)
JF1/MsJ	ENSUMUG00000004919	protein coding gene	Chr1:190313823-190463266 (+)
LP/J	ENSMUSG00230023884	protein coding gene	Chr1:190869407-191021032 (+)
NOD/ShiLtJ	ENSMUSG00190023928	protein coding gene	Chr1:186700758-186852386 (+)
NZO/HlLtJ	ENSMUSG00225015789	protein coding gene	Chr1:194632125-194785788 (+)
PWK/PhJ	ENSLUMG00010006086	protein coding gene	Chr1:185559446-185708169 (+)
SPRET/EiJ	ENSMSPG00010022755	protein coding gene	Chr1:189107916-189254318 (+)
WSB/EiJ	ENSIUOG00005004191	protein coding gene	Chr1:186061773-186210022 (+)

Human Ortholog

PTPN14, protein tyrosine phosphatase non-receptor type 14

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPN14, protein tyrosine phosphatase non-receptor type 14
Synonyms

CATLPH, PEZ, PTP36, PTPD2
Links

HGNC:9647

NCBI Gene ID: 5784

UniProt: Q15678
Chr Location

1q32.3-q41; chr1:214348700-214552449 (-) GRCh38

MGI Vertebrate Homology

Ptpn14 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PTPN14
Protein SuperFamily

Tyr-Ptase_nr14
Gene Tree

Ptpn14

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
22 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

89
Endonuclease-mediated

8
Gene trapped

75
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a gene trap allele exhibit some postnatal growth retardation, decreased body weight, periorbital and limb edema, and lymphatic vessel hyperplasia.

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All GO Annotations

33
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

709
Tissues

37
cDNA Data

73
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA PTPN14

Xenbase ptpn14

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All Sequences

73
RefSeq

14
UniProt

10
CCDS

CCDS15609.1

Ensembl

ENSMUSG00000026604 (Evidence)
NCBI Gene

19250

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026604	Ensembl Gene Model \| MGI Sequence Detail	148428	C57BL/6J	± kb
transcript	ENSMUST00000097442	Ensembl \| MGI Sequence Detail	10746	Not Applicable
polypeptide	ENSMUSP00000095051	Ensembl \| MGI Sequence Detail	1189	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000013452 tyrosine-protein phosphatase non-receptor type 14

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR019749 Band 4.1 domain

IPR014352 FERM/acyl-CoA-binding protein superfamily

IPR019748 FERM central domain

IPR019747 FERM conserved site

IPR018980 FERM, C-terminal PH-like domain

IPR000299 FERM domain

IPR018979 FERM, N-terminal

IPR035963 FERM superfamily, second domain

IPR011993 PH-like domain superfamily

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR014392 Protein-tyrosine phosphatase, non-receptor type-14/21

IPR041782 PTPN14/21, FERM domain C-lobe

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

IPR029071 Ubiquitin-like domain superfamily
GlyGen

Q62130 2 sites, 1 O-linked glycan (2 sites)

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All nucleic 75

cDNA 74

Primer pair 1

Microarray probesets 6

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MGD-MRK-19304, MGI:2442275, MGI:3705754

Summaries

All 63

Developmental Gene Expression 5

Gene Ontology 9

Phenotypes 22
Earliest

J:19880 Sawada M, et al., cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells. Biochem Biophys Res Commun. 1994 Aug 30;203(1):479-84
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ptpn14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10688	Chr1:189460445-189460456 (+)	-14 bp
Tssr10689	Chr1:189460461-189460523 (+)	27 bp
Tssr10690	Chr1:189460527-189460534 (+)	66 bp
Tssr10691	Chr1:189507216-189507258 (+)	46,772 bp
Tssr10692	Chr1:189514201-189514209 (+)	53,740 bp
Tssr10693	Chr1:189517456-189517469 (+)	56,998 bp
Tssr10694	Chr1:189530723-189530735 (+)	70,264 bp
Tssr10696	Chr1:189576860-189576866 (+)	116,398 bp
Tssr10697	Chr1:189592572-189592583 (+)	132,113 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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