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Ap1g1 Gene Detail
Summary
  • Symbol
    Ap1g1
  • Name
    adaptor protein complex AP-1, gamma 1 subunit
  • Synonyms
    Adtg, D8Ertd374e, gamma-adaptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:101919
    NCBI Gene: 11765
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:110505215-110590842 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 57.26 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1492 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_101919
 protein coding gene Chr8:110505186-110590842 (+)
129S1/SvImJ ENSMUSG00200014384
 protein coding gene Chr8:104807007-104892975 (+)
A/J ENSMUSG00195018764
 protein coding gene Chr8:105119581-105205546 (+)
AKR/J ENSMUSG00220014539
 protein coding gene Chr8:105261942-105347907 (+)
BALB/cJ ENSMUSG00180018137
 protein coding gene Chr8:105125261-105211239 (+)
C3H/HeJ ENSMUSG00175021366
 protein coding gene Chr8:105181942-105267905 (+)
C57BL/6NJ ENSMUSG00215021776
 protein coding gene Chr8:104785580-104871525 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031549
 protein coding gene Chr8:100864236-100951526 (+)
CAST/EiJ ENSTCUG00005032948
 protein coding gene Chr8:104525842-104612150 (+)
CBA/J ENSMUSG00210028469
 protein coding gene Chr8:105109168-105195138 (+)
DBA/2J ENSMUSG00185005468
 protein coding gene Chr8:111218182-111304155 (+)
FVB/NJ ENSMUSG00205017644
 protein coding gene Chr8:104115192-104201172 (+)
JF1/MsJ ENSUMUG00000009465
 protein coding gene Chr8:113551504-113637465 (+)
LP/J ENSMUSG00230031604
 protein coding gene Chr8:114898170-114984128 (+)
NOD/ShiLtJ ENSMUSG00190019399
 protein coding gene Chr8:105253933-105339927 (+)
NZO/HlLtJ ENSMUSG00225022607
 protein coding gene Chr8:118248842-118334801 (+)
PWK/PhJ ENSLUMG00010026513
 protein coding gene Chr8:104991920-105074898 (+)
SPRET/EiJ ENSMSPG00010031040
 protein coding gene Chr8:107080525-107165456 (+)
WSB/EiJ ENSIUOG00005029910
 protein coding gene Chr8:105908674-105994656 (+)



Homology
more
  • Human Ortholog
    AP1G1, adaptor related protein complex 1 subunit gamma 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AP1G1, adaptor related protein complex 1 subunit gamma 1
  • Synonyms
    ADTG, CLAPG1, USRISD
  • Links
    NCBI Gene ID: 164
    UniProt: O43747

  • Chr Location
    16q22.2; chr16:71729000-71809201 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 3 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete embryonic lethality before implantation. Heterozygotes display slow postnatal weight gain, decreased CD4-positive, alpha beta T cell number in the thymus, and decreased body size up to 10 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    670
  • Tissues
    45
  • cDNA Data
    26
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11765 NCBI Gene Model | MGI Sequence Detail 85628 C57BL/6J ±  kb
    transcript NM_009677 RefSeq | MGI Sequence Detail 6891 C57BL/6  
    polypeptide P22892 UniProt | EBI | MGI Sequence Detail 822 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 27
      Primer pair 1
      Antibodies 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-18748, MGI:1196381, MGI:2142410, MGI:2142715, MGI:2142805
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 9
      Gene Ontology 23
      Phenotypes 13
    • Earliest
      J:21440 Robinson MS, Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus. J Cell Biol. 1990 Dec;111(6 Pt 1):2319-26
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory