Tead1 MGI Mouse Gene Detail - MGI:101876 - TEA domain family member 1

Symbol

Tead1
Name

TEA domain family member 1
Synonyms

2610024B07Rik, B230114H05Rik, Gtrgeo5, mTEF-1, Tcf13, TEAD-1, TEF-1

Feature Type

protein coding gene
IDs

MGI:101876
NCBI Gene: 21676
Alliance

genome feature page
Transcription Start Sites

21 TSS

Sequence Map

Chr7:112278563-112505991 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 58.80 cM, cytoband F2
Mapping Data

3 experiments

SNPs within 2kb

5525 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_101876	protein coding gene	Chr7:112278525-112506014 (+)
129S1/SvImJ	ENSMUSG00200027900	protein coding gene	Chr7:98902247-99049125 (+)
A/J	ENSMUSG00195032097	protein coding gene	Chr7:103405961-103552846 (+)
AKR/J	ENSMUSG00220034151	protein coding gene	Chr7:96808860-96955753 (+)
BALB/cJ	ENSMUSG00180042933	protein coding gene	Chr7:100074020-100220929 (+)
C3H/HeJ	ENSMUSG00175045124	protein coding gene	Chr7:100709764-100856654 (+)
C57BL/6NJ	ENSMUSG00215049273	protein coding gene	Chr7:100017987-100165420 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030337	protein coding gene	Chr7:114955840-115189895 (+)
CAST/EiJ	ENSTCUG00005043778	protein coding gene	Chr7:103404191-103554708 (+)
CBA/J	ENSMUSG00210043238	protein coding gene	Chr7:100536737-100683629 (+)
DBA/2J	ENSMUSG00185021070	protein coding gene	Chr7:104886912-105033804 (+)
FVB/NJ	ENSMUSG00205043866	protein coding gene	Chr7:100498257-100645699 (+)
JF1/MsJ	ENSUMUG00000041818	protein coding gene	Chr7:109912345-110060818 (+)
LP/J	ENSMUSG00230046519	protein coding gene	Chr7:110987916-111134787 (+)
NOD/ShiLtJ	ENSMUSG00190043260	protein coding gene	Chr7:100698379-100845262 (+)
NZO/HlLtJ	ENSMUSG00225015965	protein coding gene	Chr7:109218889-109367383 (+)
PWK/PhJ	ENSLUMG00010032995	protein coding gene	Chr7:99047297-99195944 (+)
SPRET/EiJ	ENSMSPG00010032014	protein coding gene	Chr7:100136370-100366633 (+)
WSB/EiJ	ENSIUOG00005045077	protein coding gene	Chr7:101354704-101502012 (+)

Human Ortholog

TEAD1, TEA domain transcription factor 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEAD1, TEA domain transcription factor 1
Synonyms

AA, NTEF-1, REF1, TCF-13, TCF13, TEAD-1, TEF-1
Links

HGNC:11714

NCBI Gene ID: 7003

UniProt: P28347
Chr Location

11p15.3; chr11:12674421-12944737 (+) GRCh38

MGI Vertebrate Homology

Tead1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TEAD1
Protein SuperFamily

TEF
Gene Tree

Tead1

Diseases

1 with human TEAD1 associations

				Human Disease	Mouse Models
				Sveinsson chorioretinal atrophy IDs Sveinsson chorioretinal atrophy DOID:0111228 MESH:C566236 OMIM:108985 ORDO:86813 UMLS_CUI:C1862382

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

24 phenotypes from 4 alleles in 4 genetic backgrounds
27 phenotypes from multigenic genotypes
48 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

487
Endonuclease-mediated

5
Gene trapped

473
Radiation induced

1
Targeted

7
Transgenic

1
Genomic Mutations

1 involving Tead1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

278 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene die between embryonic day 11 and 12.5. Abnormalities were seen in heart development.

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All GO Annotations

64
GO References

26

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

990
Tissues

308
cDNA Data

29
Literature Summary

39

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tead1

ZFIN tead1a

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All Sequences

94
RefSeq

6
UniProt

19
CCDS

CCDS52365.1, CCDS52366.1, CCDS52367.1

Ensembl

ENSMUSG00000055320 (Evidence)
NCBI Gene

21676

			Length	Strain/Species	Flank
genomic	21676	NCBI Gene Model \| MGI Sequence Detail	227429	C57BL/6J	± kb
transcript	NM_001166584	RefSeq \| MGI Sequence Detail	9905	C57BL/6
polypeptide	P30051	UniProt \| EBI \| MGI Sequence Detail	426	Not Applicable

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UniProt

19 Sequences
Protein Ontology

PR:000016218 transcriptional enhancer factor TEF-1

(term hierarchy)
InterPro Domains

IPR000818 TEA/ATTS domain

IPR038096 TEA/ATTS domain superfamily

IPR016361 Transcriptional enhancer factor, metazoa

IPR041086 YAP binding domain

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All nucleic 41

cDNA 31

Primer pair 9

Other 1

Antibodies 4

Microarray probesets 5

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MGD-MRK-18702, MGD-MRK-18736, MGI:1917551, MGI:2444852

Summaries

All 148

Developmental Gene Expression 39

Gene Ontology 26

Phenotypes 48
Earliest

J:48110 Burglin TR, The TEA domain: a novel, highly conserved DNA-binding motif [letter]. Cell. 1991 Jul 12;66(1):11-2
Latest

J:372639 Atterton C, et al., The Hippo effector TEAD1 regulates postnatal murine cerebellar development. Brain Struct Funct. 2025 Mar 10;230(3):42

TSS for Tead1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68581	Chr7:112278521-112278532 (+)	-36 bp
Tssr68582	Chr7:112278534-112278580 (+)	-6 bp
Tssr68583	Chr7:112278585-112278594 (+)	27 bp
Tssr68584	Chr7:112278608-112278629 (+)	56 bp
Tssr68585	Chr7:112278633-112278638 (+)	73 bp
Tssr68586	Chr7:112278650-112278673 (+)	99 bp
Tssr68587	Chr7:112281932-112281936 (+)	3,371 bp
Tssr68588	Chr7:112286429-112286432 (+)	7,868 bp
Tssr68589	Chr7:112341232-112341267 (+)	62,687 bp
Tssr68590	Chr7:112341277-112341287 (+)	62,719 bp
Tssr68591	Chr7:112354892-112354897 (+)	76,332 bp
Tssr2375	Chr7:112402130-112402132 (+)	123,568 bp
Tssr68592	Chr7:112409004-112409017 (+)	130,448 bp
Tssr68593	Chr7:112415330-112415339 (+)	136,772 bp
Tssr68594	Chr7:112452360-112452365 (+)	173,800 bp
Tssr68595	Chr7:112455805-112455820 (+)	177,250 bp
Tssr68596	Chr7:112455823-112455832 (+)	177,265 bp
Tssr68597	Chr7:112455838-112455843 (+)	177,278 bp
Tssr68598	Chr7:112498216-112498220 (+)	219,655 bp
Tssr68599	Chr7:112499147-112499160 (+)	220,591 bp
Tssr68600	Chr7:112504108-112504113 (+)	225,548 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24