Ppm1b MGI Mouse Gene Detail - MGI:101841 - protein phosphatase 1B, magnesium dependent, beta isoform

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Ppm1b Gene Detail

Symbol

Ppm1b
Name

protein phosphatase 1B, magnesium dependent, beta isoform
Synonyms

PP2CB

Feature Type

protein coding gene
IDs

MGI:101841
NCBI Gene: 19043
Alliance

gene page
Transcription Start Sites

6 TSS
Candidate for QTL

3 QTL

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Sequence Map

Chr17:85264169-85331419 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 55.13 cM, cytoband E4-E5
Mapping Data

4 experiments

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SNPs within 2kb

37 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_101841	protein coding gene	Chr17:85264169-85331420 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024084	protein coding gene	Chr17:88157436-88222835 (+)
A/J	MGP_AJ_G0024043	protein coding gene	Chr17:85349330-85420117 (+)
AKR/J	MGP_AKRJ_G0024012	protein coding gene	Chr17:86750544-86811053 (+)
BALB/cJ	MGP_BALBcJ_G0024044	protein coding gene	Chr17:85199383-85269525 (+)
C3H/HeJ	MGP_C3HHeJ_G0023809	protein coding gene	Chr17:87653028-87664052 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024489	protein coding gene	Chr17:91318681-91342737 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021928	protein coding gene	Chr17:80550474-80621350 (+)
CAST/EiJ	MGP_CASTEiJ_G0023288	protein coding gene	Chr17:88400980-88472565 (+)
CBA/J	MGP_CBAJ_G0023783	protein coding gene	Chr17:95060252-95127197 (+)
DBA/2J	MGP_DBA2J_G0023911	protein coding gene	Chr17:83828166-83887875 (+)
FVB/NJ	MGP_FVBNJ_G0023877	protein coding gene	Chr17:83313280-83388120 (+)
LP/J	MGP_LPJ_G0023995	protein coding gene	Chr17:88931865-89006707 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023905	protein coding gene	Chr17:95091710-95171495 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024534	protein coding gene	Chr17:87236309-87311271 (+)
PWK/PhJ	MGP_PWKPhJ_G0023033	protein coding gene	Chr17:83410135-83479291 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022844	protein coding gene	Chr17:84063903-84132933 (+)
WSB/EiJ	MGP_WSBEiJ_G0023354	protein coding gene	Chr17:88103561-88175566 (+)

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Human Ortholog

PPM1B, protein phosphatase, Mg2+/Mn2+ dependent 1B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPM1B, protein phosphatase, Mg2+/Mn2+ dependent 1B
Synonyms

PP2CB, PP2C-beta, PP2CBETA, PP2C-beta-X, PPC2BETAX
Links

HGNC:9276

NCBI Gene ID: 5495

neXtProt AC: NX_O75688

UniProt: O75688
Chr Location

2p21; chr2:44168803-44247330 (+) GRCh38.p7

Alliance of Genome Resources

Ppm1b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPM1B
Gene Tree

Ppm1b

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Phenotype Summary

5 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
11 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

24
Gene trapped

19
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available

Homozygous KO results in early pre-implantation lethality. A hypomorphic mutation results in increased sensitivity to Tnf-induced necroptosis and early death.

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All GO Annotations

28
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

731
Tissues

15
cDNA Data

27
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppm1b

ZFIN ppm1bb

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Ppm1b interacts with 318 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

108
RefSeq

41
UniProt

5
CCDS

CCDS37710.1, CCDS50199.1, CCDS50200.1, CCDS50201.1

Ensembl

ENSMUSG00000061130 (Evidence)
NCBI Gene

19043

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000061130	Ensembl Gene Model \| MGI Sequence Detail	67251	C57BL/6J	± kb
	transcript	ENSMUST00000080217	Ensembl \| MGI Sequence Detail	2670	Not Applicable
	polypeptide	ENSMUSP00000079107	Ensembl \| MGI Sequence Detail	477	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013091 protein phosphatase 1B

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR036580 Phosphatase 2C, C-terminal domain superfamily

IPR000222 PPM-type phosphatase, divalent cation binding

IPR001932 PPM-type phosphatase-like domain

IPR036457 PPM-type phosphatase-like domain superfamily

IPR015655 Protein phosphatase 2C family

IPR012911 Protein serine/threonine phosphatase 2C, C-terminal

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All nucleic 29

Genomic 2

cDNA 27

Microarray probesets 10

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MGD-MRK-18662

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Summaries

All 44

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 11
Earliest

J:19661 Terasawa T, et al., Molecular cloning of a novel isotype of Mg(2+)-dependent protein phosphatase beta (type 2C beta) enriched in brain and heart. Arch Biochem Biophys. 1993 Dec;307(2):342-9
Latest

J:307571 Ishii N, et al., A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice. Mol Med Rep. 2019 Jun;19(6):5353-5360

TSS for Ppm1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr146069	Chr17:85264146-85264173 (+)	-9 bp
Tssr146070	Chr17:85264554-85264566 (+)	391 bp
Tssr146071	Chr17:85265421-85265446 (+)	1,265 bp
Tssr146072	Chr17:85270414-85270418 (+)	6,247 bp
Tssr146073	Chr17:85272459-85272478 (+)	8,300 bp
Tssr146074	Chr17:85326345-85326347 (+)	62,177 bp

Ppm1b is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Insq5	Chr17, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 17, Tbp (8.25 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Obq4 (4 cM) maps near candidate gene Tbp. Vegfa (28 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Trbv4c1 (23 cM) maps near candidate gene Vegfa. Ppm1b (50.8 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Insq5 (56.7 cM) maps near candidate gene Ppm1b.
Obq4	Chr17, 4.92 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 17, Tbp (8.25 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Obq4 (4 cM) maps near candidate gene Tbp. Vegfa (28 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Trbv4c1 (23 cM) maps near candidate gene Vegfa. Ppm1b (50.8 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Insq5 (56.7 cM) maps near candidate gene Ppm1b.
Trbv4c1	Chr17, 20.67 cM		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 17, Tbp (8.25 cM) shows differential expression between A/a and A/A animals on the unrestricted diet. Diabesity QTL Obq4 (4 cM) maps near candidate gene Tbp. Vegfa (28 cM) shows differential expression between A/a and A/A animals on the restricted diet. Diabesity QTL Trbv4c1 (23 cM) maps near candidate gene Vegfa. Ppm1b (50.8 cM) shows differential expression between the restricted and unrestricted diets on the A/A background. Diabesity QTL Insq5 (56.7 cM) maps near candidate gene Ppm1b.

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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