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Pyy Gene Detail
Summary
  • Symbol
    Pyy
  • Name
    peptide YY
  • Synonyms
    MGC:19143
  • Feature Type
    protein coding gene
  • IDs
    MGI:99924
    NCBI Gene: 217212
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:101997502-101998658 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 65.48 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    182 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99924
 protein coding gene Chr11:101997502-101998658 (-)
129S1/SvImJ ENSMUSG00200052407
 protein coding gene Chr11:99284024-99285180 (-)
A/J ENSMUSG00195052209
 protein coding gene Chr11:98979700-98980856 (-)
AKR/J ENSMUSG00220050855
 protein coding gene Chr11:99199447-99200603 (-)
BALB/cJ ENSMUSG00180049659
 protein coding gene Chr11:99331663-99332819 (-)
C3H/HeJ ENSMUSG00175040860
 protein coding gene Chr11:99257522-99258678 (-)
C57BL/6NJ ENSMUSG00215052062
 protein coding gene Chr11:98819143-98820299 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017238
 protein coding gene Chr11:98043641-98044795 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210052448
 protein coding gene Chr11:98964976-98966132 (-)
DBA/2J ENSMUSG00185050941
 protein coding gene Chr11:99307394-99308550 (-)
FVB/NJ ENSMUSG00205047901
 protein coding gene Chr11:99149864-99151020 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230050599
 protein coding gene Chr11:100359966-100361122 (-)
NOD/ShiLtJ ENSMUSG00190040570
 protein coding gene Chr11:99346359-99347515 (-)
NZO/HlLtJ ENSMUSG00225049694
 protein coding gene Chr11:102382719-102383875 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PYY, peptide YY
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PYY, peptide YY
  • Synonyms
    PYY1, PYY-I
  • Links
    NCBI Gene ID: 5697
    UniProt: P10082

  • Chr Location
    17q21.31; chr17:43952733-44004469 (-)  GRCh38
  • Human Ortholog
    PYY3, peptide YY 3 (pseudogene)
  • Synonyms
    PYY-III
  • Links
    NCBI Gene ID: 644059
    UniProt: Q5JQD4

  • Chr Location
    Xp11.22; chrX:50156066-50156596 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    43 phenotypes from 6 alleles in 6 genetic backgrounds
    2 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null mutation showed normal growth, food intake, and energy expenditure. Mice homozygous for another null allele exhibit polyphagia, increased adipose tissue and are resistant to the benefits of a high-protein diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    650
  • Tissues
    20
  • cDNA Data
    15
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 217212 NCBI Gene Model | MGI Sequence Detail 1157 C57BL/6J ±  kb
    transcript NM_001346771 RefSeq | MGI Sequence Detail 574 C57BL/6  
    polypeptide Q9EPS2 UniProt | EBI | MGI Sequence Detail 98 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 15
      Primer pair 3
      Other 2
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16726
    References
    more
    • Summaries
      All 96
      Developmental Gene Expression 26
      Gene Ontology 9
      Phenotypes 32
    • Earliest
      J:16874 Upchurch BH, et al., Expression of peptide YY in all four islet cell types in the developing mouse pancreas suggests a common peptide YY-producing progenitor. Development. 1994 Feb;120(2):245-52
    • Latest
      J:374474 Jimenez S, et al., Unraveling enteroendocrine cell lineage dynamics and associated gene regulatory networks during intestinal development. Biol Open. 2025 Oct 15;14(10)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory