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Krtap11-1 Gene Detail
Summary
  • Symbol
    Krtap11-1
  • Name
    keratin associated protein 11-1
  • Synonyms
    Hacl1, KAP11.1, PRED29
  • Feature Type
    protein coding gene
  • IDs
    MGI:99447
    NCBI Gene: 16693
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:89367064-89368071 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 51.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99447
 protein coding gene Chr16:89367064-89368071 (-)
129S1/SvImJ ENSMUSG00200036810
 protein coding gene Chr16:86240624-86241631 (-)
A/J ENSMUSG00195026971
 protein coding gene Chr16:86046476-86047483 (-)
AKR/J ENSMUSG00220015689
 protein coding gene Chr16:86231496-86232503 (-)
BALB/cJ ENSMUSG00180014401
 protein coding gene Chr16:86119666-86120673 (-)
C3H/HeJ ENSMUSG00175013043
 protein coding gene Chr16:86457883-86458890 (-)
C57BL/6NJ ENSMUSG00215015877
 protein coding gene Chr16:86247965-86248972 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020941
 protein coding gene Chr16:83981433-83982440 (-)
CAST/EiJ ENSTCUG00005019797
 protein coding gene Chr16:85802798-85803805 (-)
CBA/J ENSMUSG00210032199
 protein coding gene Chr16:86342281-86343288 (-)
DBA/2J ENSMUSG00185030505
 protein coding gene Chr16:86293613-86294620 (-)
FVB/NJ ENSMUSG00205013146
 protein coding gene Chr16:86093181-86094188 (-)
JF1/MsJ ENSUMUG00000028389
 protein coding gene Chr16:86415343-86416350 (-)
LP/J ENSMUSG00230032966
 protein coding gene Chr16:88787904-88788911 (-)
NOD/ShiLtJ ENSMUSG00190019720
 protein coding gene Chr16:86274165-86275172 (-)
NZO/HlLtJ ENSMUSG00225030651
 protein coding gene Chr16:91966856-91967863 (-)
PWK/PhJ ENSLUMG00010012129
 protein coding gene Chr16:86036169-86037176 (-)
SPRET/EiJ ENSMSPG00010028509
 protein coding gene Chr16:87236989-87237994 (-)
WSB/EiJ ENSIUOG00005019888
 protein coding gene Chr16:86198143-86199149 (-)



Homology
more
  • Human Ortholog
    KRTAP11-1, keratin associated protein 11-1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRTAP11-1, keratin associated protein 11-1
  • Synonyms
    HACL-1, KAP11.1
  • Links
    NCBI Gene ID: 337880
    UniProt: Q8IUC1

  • Chr Location
    21q22.11; chr21:30880644-30881580 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    688
  • Tissues
    81
  • cDNA Data
    36
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16693 NCBI Gene Model | MGI Sequence Detail 1008 C57BL/6J ±  kb
transcript NM_001113406 RefSeq | MGI Sequence Detail 1008 C57BL/6  
polypeptide NP_001106877 RefSeq | MGI Sequence Detail 183 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR007951 Keratin-associated protein, PMG type
    IPR007659 Keratin, high-sulphur matrix protein
  • GlyGen
    E9Q2E9 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 39
    Genomic 1
    cDNA 36
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16215, MGI:2146357, MGI:2146590, MGI:2652094
References
more
  • Summaries
    All 33
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:17984 Huh N, et al., Isolation and characterization of a novel hair follicle-specific gene, Hacl-1. J Invest Dermatol. 1994 May;102(5):716-20
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory