Yes1 MGI Mouse Gene Detail - MGI:99147 - YES proto-oncogene 1, Src family tyrosine kinase

Symbol

Yes1
Name

YES proto-oncogene 1, Src family tyrosine kinase
Synonyms

Yes

Feature Type

protein coding gene
IDs

MGI:99147
NCBI Gene: 22612
Alliance

genome feature page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:32768515-32844401 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 17.33 cM
Mapping Data

3 experiments

SNPs within 2kb

1148 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99147	protein coding gene	Chr5:32768502-32844410 (+)
129S1/SvImJ	ENSMUSG00200012524	protein coding gene	Chr5:28242619-28309997 (+)
A/J	ENSMUSG00195048028	protein coding gene	Chr5:27715918-27783291 (+)
AKR/J	ENSMUSG00220007800	protein coding gene	Chr5:27737978-27805356 (+)
BALB/cJ	ENSMUSG00180029634	protein coding gene	Chr5:27520467-27587846 (+)
C3H/HeJ	ENSMUSG00175043822	protein coding gene	Chr5:29500107-29567484 (+)
C57BL/6NJ	ENSMUSG00215040054	protein coding gene	Chr5:28231917-28307805 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027104	protein coding gene	Chr5:27348013-27410840 (+)
CAST/EiJ	ENSTCUG00005022213	protein coding gene	Chr5:27727628-27794491 (+)
CBA/J	ENSMUSG00210046755	protein coding gene	Chr5:28467868-28535246 (+)
DBA/2J	ENSMUSG00185015774	protein coding gene	Chr5:30323083-30398968 (+)
FVB/NJ	ENSMUSG00205015354	protein coding gene	Chr5:27221049-27288423 (+)
JF1/MsJ	ENSUMUG00000039132	protein coding gene	Chr5:34918145-34984977 (+)
LP/J	ENSMUSG00230044582	protein coding gene	Chr5:34946358-35013733 (+)
NOD/ShiLtJ	ENSMUSG00190015127	protein coding gene	Chr5:27486849-27562735 (+)
NZO/HlLtJ	ENSMUSG00225016624	protein coding gene	Chr5:40153960-40221335 (+)
PWK/PhJ	ENSLUMG00010037762	protein coding gene	Chr5:27632218-27699066 (+)
SPRET/EiJ	ENSMSPG00010042993	protein coding gene	Chr5:28799567-28867550 (+)
WSB/EiJ	ENSIUOG00005034081	protein coding gene	Chr5:30423962-30491363 (+)

Human Ortholog

YES1, YES proto-oncogene 1, Src family tyrosine kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

YES1, YES proto-oncogene 1, Src family tyrosine kinase
Synonyms

c-yes, HsT441, P61-YES, Yes
Links

HGNC:12841

NCBI Gene ID: 7525

UniProt: P07947
Chr Location

18p11.32; chr18:721588-813276 (-) GRCh38

MGI Vertebrate Homology

Yes1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: YES1
Gene Tree

Yes1

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 2 alleles in 2 genetic backgrounds
21 phenotypes from multigenic genotypes
49 phenotype references

All Mutations and Alleles

143
Chemically induced (ENU)

1
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

130
Radiation induced

2
Spontaneous

1
Targeted

3
Genomic Mutations

6 involving Yes1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

140 strains or lines available

Homozygotes for targeted null alleles have no overt phenotype, but mice homozygous for both Yes and Src null mutations exhibit impaired movement and breathing, resulting in perinatal lethality.

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All GO Annotations

51
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

646
Tissues

42
cDNA Data

15
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase yes1

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All Sequences

53
RefSeq

8
UniProt

6
CCDS

CCDS39061.1

Ensembl

ENSMUSG00000014932 (Evidence)
NCBI Gene

22612

			Length	Strain/Species	Flank
genomic	ENSMUSG00000014932	Ensembl Gene Model \| MGI Sequence Detail	75887	C57BL/6J	± kb
transcript	ENSMUST00000202543	Ensembl \| MGI Sequence Detail	2657	Not Applicable
polypeptide	ENSMUSP00000144001	Ensembl \| MGI Sequence Detail	541	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000017528 tyrosine-protein kinase Yes

(term hierarchy)
PDB

2YT6, 5MTJ
EC

2.7.10.2
InterPro Domains

IPR043539 Grb2-like

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR035751 Tyrosine-protein kinase Yes, SH3 domain
GlyGen

Q04736 4 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 21

cDNA 17

Primer pair 3

Other 1

Antibodies 3

Microarray probesets 4

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MGD-MRK-15844, MGI:2140834

Summaries

All 133

Developmental Gene Expression 10

Diseases 1

Gene Ontology 15

Phenotypes 49
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:362725 Guegan JP, et al., Signaling by the tyrosine kinase Yes promotes liver cancer development. Sci Signal. 2022 Jan 18;15(717):eabj4743

TSS for Yes1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45787	Chr5:32767649-32767658 (+)	-861 bp
Tssr45788	Chr5:32767669-32767679 (+)	-841 bp
Tssr45789	Chr5:32767698-32767718 (+)	-807 bp
Tssr45790	Chr5:32768539-32768589 (+)	49 bp
Tssr45791	Chr5:32768591-32768609 (+)	85 bp
Tssr45792	Chr5:32770833-32770838 (+)	2,321 bp
Tssr45793	Chr5:32794607-32794612 (+)	26,095 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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