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Tcn2 Gene Detail
Summary
  • Symbol
    Tcn2
  • Name
    transcobalamin 2
  • Synonyms
    Tcn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98534
    NCBI Gene: 21452
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3867192-3882159 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.76 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98534
 protein coding gene Chr11:3867077-3882159 (-)
129S1/SvImJ ENSMUSG00200029874
 protein coding gene Chr11:821281-836247 (-)
A/J ENSMUSG00195021392
 protein coding gene Chr11:728536-743506 (-)
AKR/J ENSMUSG00220007902
 protein coding gene Chr11:741598-756564 (-)
BALB/cJ ENSMUSG00180020942
 protein coding gene Chr11:751320-766287 (-)
C3H/HeJ ENSMUSG00175009223
 protein coding gene Chr11:741109-756079 (-)
C57BL/6NJ ENSMUSG00215022544
 protein coding gene Chr11:751495-766467 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016020
 protein coding gene Chr11:747116-762559 (-)
CAST/EiJ ENSTCUG00005038332
 protein coding gene Chr11:839961-855191 (-)
CBA/J ENSMUSG00210017856
 protein coding gene Chr11:740748-755718 (-)
DBA/2J ENSMUSG00185017466
 protein coding gene Chr11:838462-853432 (-)
FVB/NJ ENSMUSG00205019101
 protein coding gene Chr11:717079-732047 (-)
JF1/MsJ ENSUMUG00000034940
 protein coding gene Chr11:1002984-1017997 (-)
LP/J ENSMUSG00230033782
 protein coding gene Chr11:1904451-1919417 (-)
NOD/ShiLtJ ENSMUSG00190031355
 protein coding gene Chr11:728297-743263 (-)
NZO/HlLtJ ENSMUSG00225025626
 protein coding gene Chr11:3961203-3976174 (-)
PWK/PhJ ENSLUMG00010018677
 protein coding gene Chr11:728626-743596 (-)
SPRET/EiJ ENSMSPG00010008441
 protein coding gene Chr11:816563-831816 (-)
WSB/EiJ ENSIUOG00005006514
 protein coding gene Chr11:742000-756974 (-)



Homology
more
  • Human Ortholog
    TCN2, transcobalamin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCN2, transcobalamin 2
  • Synonyms
    D22S676, D22S750, II, TC, TC-2, TC2, TC II, TCII
  • Links
    NCBI Gene ID: 6948
    UniProt: P20062

  • Chr Location
    22q12.2; chr22:30607003-30627631 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human TCN2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
This locus controls transcobalamin-2 electrophoretic variation. The s allele determines a slow band in serum from A/J, C57BL/6, BALB/c and C3H/He; the f allele determines faster form in NZB, ST/b and CPB-WV. Heterozygotes have both forms. Sequencing reveals a Gly to Glu substitution in NZB compared to BALB/c, DBA/2 and C57BL/6 (Genbank AF090686).
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    27
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    806
  • Tissues
    174
  • cDNA Data
    390
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020432 Ensembl Gene Model | MGI Sequence Detail 14968 C57BL/6J ±  kb
transcript ENSMUST00000109990 Ensembl | MGI Sequence Detail 1914 Not Applicable  
polypeptide ENSMUSP00000105617 Ensembl | MGI Sequence Detail 430 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 391
    cDNA 390
    Other 1
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14807, MGD-MRK-14808, MGI:2144509
References
more
  • Summaries
    All 60
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 6
  • Earliest
    J:319903 DiGirolamo PM, et al., Transport of vitamin B12 into mouse leukemia cells. Arch Biochem Biophys. 1975 Jun;168(2):386-93
  • Latest
    J:374597 Jiang S, et al., Multimodal analysis stratifies genetic susceptibility and reveals the pathogenic mechanism of kidney injury in diabetic nephropathy. Cell Rep Med. 2025 Aug 19;6(8):102249
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory