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Rps6 Gene Detail
Summary
  • Symbol
    Rps6
  • Name
    ribosomal protein S6
  • Synonyms
    S6R
  • Feature Type
    protein coding gene
  • IDs
    MGI:98159
    NCBI Gene: 20104
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:86772897-86775649 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 40.69 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    29
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98159
 protein coding gene Chr4:86772336-86775649 (-)
129S1/SvImJ ENSMUSG00200015917
 protein coding gene ChrX:50777037-50778432 (-)
129S1/SvImJ ENSMUSG00200009267
 protein coding gene Chr4:81732061-81734813 (-)
A/J ENSMUSG00195008462
 protein coding gene Chr4:82311401-82314158 (-)
A/J ENSMUSG00195032483
 protein coding gene ChrX:54386420-54387815 (-)
AKR/J ENSMUSG00220019141
 protein coding gene Chr4:81694212-81696964 (-)
AKR/J ENSMUSG00220023874
 protein coding gene ChrX:49695106-49696501 (-)
BALB/cJ ENSMUSG00180006616
 protein coding gene ChrX:50986113-50987508 (-)
BALB/cJ ENSMUSG00180005497
 protein coding gene Chr4:81276293-81279046 (-)
C3H/HeJ ENSMUSG00175034902
 protein coding gene ChrX:54549921-54551319 (-)
C3H/HeJ ENSMUSG00175007317
 protein coding gene Chr4:82191258-82194010 (-)
C57BL/6NJ ENSMUSG00215007630
 protein coding gene ChrX:51035952-51037347 (-)
C57BL/6NJ ENSMUSG00215013704
 protein coding gene Chr4:82145346-82148098 (-)
C57BL/6NJ ENSMUSG00215020087
 protein coding gene Chr2:72133549-72134517 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026135
 protein coding gene Chr4:79698301-79701082 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210016127
 protein coding gene Chr4:81777987-81780739 (-)
CBA/J ENSMUSG00210034563
 protein coding gene ChrX:51233569-51234967 (-)
DBA/2J ENSMUSG00185002916
 protein coding gene Chr4:82393117-82395869 (-)
DBA/2J ENSMUSG00185031293
 protein coding gene ChrX:63682665-63684060 (-)
FVB/NJ ENSMUSG00205009023
 protein coding gene ChrX:50802881-50804277 (-)
FVB/NJ ENSMUSG00205001261
 protein coding gene Chr4:80662215-80664968 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230018525
 protein coding gene ChrX:70238641-70240036 (-)
LP/J ENSMUSG00230015269
 protein coding gene Chr4:85809956-85816147 (-)
NOD/ShiLtJ ENSMUSG00190012807
 protein coding gene ChrX:50570357-50571752 (-)
NOD/ShiLtJ ENSMUSG00190015823
 protein coding gene Chr4:81223802-81226554 (-)
NZO/HlLtJ ENSMUSG00225014252
 protein coding gene Chr2:81733948-81734916 (-)
NZO/HlLtJ ENSMUSG00225004650
 protein coding gene Chr4:90892178-90897547 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010014207
 protein coding gene Chr4:82236404-82239264 (-)
WSB/EiJ ENSIUOG00005012141
 protein coding gene Chr4:81588148-81590901 (-)



Homology
more
  • Human Ortholog
    RPS6, ribosomal protein S6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RPS6, ribosomal protein S6
  • Synonyms
    eS6, S6
  • Links
    NCBI Gene ID: 6194
    UniProt: P62753

  • Chr Location
    9p22.1; chr9:19375715-19380282 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with an inducible, liver-specific null mutation exhibit failure of liver regeneration and an absence of 40S ribosomes in hepatocytes. Mice with a mutation where serines are unphosphorylatable exhibit hypoinsulinemia, impaired glucose tolerance, and smaller MEFs and beta cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    70
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    945
  • Tissues
    80
  • cDNA Data
    28
  • Literature Summary
    157
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028495 Ensembl Gene Model | MGI Sequence Detail 2753 C57BL/6J ±  kb
    transcript ENSMUST00000102814 Ensembl | MGI Sequence Detail 878 Not Applicable  
    polypeptide ENSMUSP00000099878 Ensembl | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 2
      cDNA 30
      Primer pair 1
      Antibodies 23

      Microarray probesets 12
    Other
    Accession IDs
    less
    MGD-MRK-14186
    References
    more
    • Summaries
      All 244
      Developmental Gene Expression 157
      Gene Ontology 19
      Phenotypes 29
    • Earliest
      J:8776 Lalanne JL, et al., Complete sequence of mouse S6 ribosomal protein. Nucleic Acids Res. 1987 Jun 25;15(12):4990
    • Latest
      J:388924 Yang X, et al., Knockin expression of human ADAMTS5 impairs cardiovascular development and aggravates cerebral cavernous malformations in mice. Dis Model Mech. 2026 May 1;19(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory