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Pygl Gene Detail
Summary
  • Symbol
    Pygl
  • Name
    liver glycogen phosphorylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:97829
    NCBI Gene: 110095
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:70237589-70274457 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 29.01 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1371 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97829
 protein coding gene Chr12:70237585-70278262 (-)
129S1/SvImJ ENSMUSG00200028670
 protein coding gene Chr12:62157367-62198045 (-)
A/J ENSMUSG00195013867
 protein coding gene Chr12:64855045-64893682 (-)
AKR/J ENSMUSG00220014379
 protein coding gene Chr12:62655413-62696106 (-)
BALB/cJ ENSMUSG00180032968
 protein coding gene Chr12:63854117-63892767 (-)
C3H/HeJ ENSMUSG00175027484
 protein coding gene Chr12:66948496-66987127 (-)
C57BL/6NJ ENSMUSG00215021815
 protein coding gene Chr12:63226733-63267409 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017818
 protein coding gene Chr12:64850145-64887462 (-)
CAST/EiJ ENSTCUG00005033167
 protein coding gene Chr12:63181958-63222832 (-)
CBA/J ENSMUSG00210027012
 protein coding gene Chr12:63418500-63457136 (-)
DBA/2J ENSMUSG00185004628
 protein coding gene Chr12:65317877-65356503 (-)
FVB/NJ ENSMUSG00205024736
 protein coding gene Chr12:63060000-63098634 (-)
JF1/MsJ ENSUMUG00000024769
 protein coding gene Chr12:69275831-69316665 (-)
LP/J ENSMUSG00230014962
 protein coding gene Chr12:72283034-72323715 (-)
NOD/ShiLtJ ENSMUSG00190011652
 protein coding gene Chr12:62471799-62512485 (-)
NZO/HlLtJ ENSMUSG00225037739
 protein coding gene Chr12:74359379-74400056 (-)
PWK/PhJ ENSLUMG00010028787
 protein coding gene Chr12:63347945-63388826 (-)
SPRET/EiJ ENSMSPG00010026566
 protein coding gene Chr12:65030103-65071748 (-)
WSB/EiJ ENSIUOG00005011578
 protein coding gene Chr12:63110298-63151015 (-)



Homology
more
  • Human Ortholog
    PYGL, glycogen phosphorylase L
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PYGL, glycogen phosphorylase L
  • Synonyms
    GSD6
  • Links
    NCBI Gene ID: 5836
    UniProt: P06737

  • Chr Location
    14q22.1; chr14:50857891-50944734 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Pygl mouse models; 3 with human PYGL associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit hepatomegaly, hepatic glycogen accumulation, ketotic hypoglycemia, activated hepatic stellate cells, inflammatory infiltrates in hepatic vessels, elevated serum transaminases and model glycogen storage disease.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    106
  • cDNA Data
    10
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110095 NCBI Gene Model | MGI Sequence Detail 36869 C57BL/6J ±  kb
    transcript NM_133198 RefSeq | MGI Sequence Detail 2821 ZRU/MplStud  
    polypeptide Q9ET01 UniProt | EBI | MGI Sequence Detail 850 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 11
      Primer pair 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-13702
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 14
      Diseases 1
      Gene Ontology 17
      Phenotypes 13
    • Earliest
      J:9387 Aldrich CJ, et al., Regulation of Qa-1 expression and determinant modification by an H-2D-linked gene, Qdm. Immunogenetics. 1988;28(5):334-44
    • Latest
      J:384234 Choi W, et al., Glycogen phosphorylase L confers metabolic flexibility in neutrophils to fight fungal infections in nutrient-deprived tissues. Cell Host Microbe. 2026 Apr 8;34(4):692-707.e6
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory