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Prkar1b Gene Detail
Summary
  • Symbol
    Prkar1b
  • Name
    protein kinase, cAMP dependent regulatory, type I beta
  • Synonyms
    RIbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:97759
    NCBI Gene: 19085
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139003061-139135756 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 77.74 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3735 from dbSNP Build 142
  • Strain Annotations
    27
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97759
 protein coding gene Chr5:139003059-139136458 (-)
129S1/SvImJ ENSMUSGG00200054598
 protein coding gene Chr5:132871725-132961101 (-)
129S1/SvImJ ENSMUSG00200039694
 protein coding gene Chr5:132962873-132982168 (-)
A/J ENSMUSGG00195055450
 protein coding gene Chr5:132492116-132581517 (-)
A/J ENSMUSG00195040191
 protein coding gene Chr5:132583289-132602590 (-)
AKR/J ENSMUSGG00220054322
 protein coding gene Chr5:131754284-131843682 (-)
AKR/J ENSMUSG00220020681
 protein coding gene Chr5:131845454-131864755 (-)
BALB/cJ ENSMUSG00180033013
 protein coding gene Chr5:132679789-132699092 (-)
BALB/cJ ENSMUSGG00180055585
 protein coding gene Chr5:132588627-132678017 (-)
C3H/HeJ ENSMUSG00175036562
 protein coding gene Chr5:134608054-134627359 (-)
C3H/HeJ ENSMUSGG00175055064
 protein coding gene Chr5:134516877-134606282 (-)
C57BL/6NJ ENSMUSGG00215055280
 protein coding gene Chr5:132447212-132536609 (-)
C57BL/6NJ ENSMUSG00215038037
 protein coding gene Chr5:132538381-132557682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027924
 protein coding gene Chr5:131728635-131863421 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054691
 protein coding gene Chr5:133334089-133423489 (-)
CBA/J ENSMUSG00210022676
 protein coding gene Chr5:133425261-133444562 (-)
DBA/2J ENSMUSG00185051945
 protein coding gene Chr5:136440614-136459913 (-)
DBA/2J ENSMUSGG00185057396
 protein coding gene Chr5:136349452-136438842 (-)
FVB/NJ ENSMUSG00205036174
 protein coding gene Chr5:132240529-132259826 (-)
FVB/NJ ENSMUSGG00205054130
 protein coding gene Chr5:132149346-132238758 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230041279
 protein coding gene Chr5:140553661-140572958 (-)
LP/J ENSMUSGG00230055398
 protein coding gene Chr5:140462500-140551889 (-)
NOD/ShiLtJ ENSMUSG00190037744
 protein coding gene Chr5:132379426-132398723 (-)
NOD/ShiLtJ ENSMUSGG00190055040
 protein coding gene Chr5:132288268-132377654 (-)
NZO/HlLtJ ENSMUSG00225023620
 protein coding gene Chr5:148028030-148047342 (-)
NZO/HlLtJ ENSMUSGG00225055692
 protein coding gene Chr5:147937243-148026258 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010030590
 protein coding gene Chr5:134556610-134669177 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PRKAR1B, protein kinase cAMP-dependent type I regulatory subunit beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRKAR1B, protein kinase cAMP-dependent type I regulatory subunit beta
  • Synonyms
    MASNS, PRKAR1
  • Links
    NCBI Gene ID: 5575
    UniProt: P31321

  • Chr Location
    7p22.3; chr7:549196-728934 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have reduced LTD and LTP in specific CNS tracts, but normal neuroanatomy and behavior. Response to pain after inflammation is reduced, concurrent with decreased plasma extravasation during the inflammatory response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    59
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1044
  • Tissues
    217
  • cDNA Data
    71
  • Literature Summary
    12
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025855 Ensembl Gene Model | MGI Sequence Detail 132696 C57BL/6J ±  kb
transcript ENSMUST00000026973 Ensembl | MGI Sequence Detail 2637 Not Applicable  
polypeptide ENSMUSP00000026973 Ensembl | MGI Sequence Detail 381 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    13 Sequences
  • Protein Ontology
    PR:000013229 cAMP-dependent protein kinase type I-beta regulatory subunit
    (term hierarchy)
  • EC
    2.7.1.37
  • InterPro Domains
    IPR012198 cAMP-dependent protein kinase regulatory subunit
    IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
    IPR050503 cAMP-dependent protein kinase regulatory subunit-like
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding domain superfamily
    IPR014710 PpnP-like, jelly roll fold
    IPR042818 RIbeta, dimerization/docking domain
  • GlyGen
    P12849 1 site
Molecular
Reagents
less
  • All nucleic 84
    Genomic 10
    cDNA 71
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-13610, MGI:2140854
References
more
  • Summaries
    All 66
    Developmental Gene Expression 12
    Gene Ontology 18
    Phenotypes 10
  • Earliest
    J:39500 Clegg CH, et al., Genetic characterization of a brain-specific form of the type I regulatory subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3703-7
  • Latest
    J:371634 Wang Y, et al., Postsynaptic competition between calcineurin and PKA regulates mammalian sleep-wake cycles. Nature. 2024 Dec;636(8042):412-421
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory