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Slc3a2 Gene Detail
Summary
  • Symbol
    Slc3a2
  • Name
    solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
  • Synonyms
    4F2HC, Cd98, Ly-10, Ly-m10, Mdu1, Mgp-2hc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96955
    NCBI Gene: 17254
  • Alliance
    genome feature page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8684931-8700733 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    25
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96955
 protein coding gene Chr19:8684246-8700733 (-)
129S1/SvImJ ENSMUSG00200046064
 protein coding gene Chr19:5416505-5416848 (-)
129S1/SvImJ ENSMUSGG00200055015
 protein coding gene Chr19:5410683-5415024 (-)
A/J ENSMUSG00195047586
 protein coding gene Chr19:5818000-5818343 (-)
A/J ENSMUSGG00195055558
 protein coding gene Chr19:5812178-5816519 (-)
AKR/J ENSMUSGG00220054980
 protein coding gene Chr19:5585421-5589762 (-)
AKR/J ENSMUSG00220046530
 protein coding gene Chr19:5591243-5591586 (-)
BALB/cJ ENSMUSG00180036057
 protein coding gene Chr19:6181987-6182330 (-)
BALB/cJ ENSMUSGG00180055639
 protein coding gene Chr19:6176165-6180506 (-)
C3H/HeJ ENSMUSGG00175055200
 protein coding gene Chr19:5449917-5454258 (-)
C3H/HeJ ENSMUSG00175013770
 protein coding gene Chr19:5455739-5456082 (-)
C57BL/6NJ ENSMUSGG00215055866
 protein coding gene Chr19:5651126-5655467 (-)
C57BL/6NJ ENSMUSG00215045917
 protein coding gene Chr19:5656948-5657291 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022647
 protein coding gene Chr19:5899742-5915452 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210055098
 protein coding gene Chr19:5466383-5470731 (-)
DBA/2J ENSMUSGG00185058007
 protein coding gene Chr19:5821071-5825419 (-)
FVB/NJ ENSMUSGG00205054709
 protein coding gene Chr19:5508114-5512453 (-)
FVB/NJ ENSMUSG00205032814
 protein coding gene Chr19:5513936-5514279 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055924
 protein coding gene Chr19:6737344-6741685 (-)
LP/J ENSMUSG00230052131
 protein coding gene Chr19:6743166-6743509 (-)
NOD/ShiLtJ ENSMUSGG00190055162
 protein coding gene Chr19:5345735-5350076 (-)
NOD/ShiLtJ ENSMUSG00190038249
 protein coding gene Chr19:5351557-5351900 (-)
NZO/HlLtJ ENSMUSGG00225055174
 protein coding gene Chr19:10446138-10450479 (-)
NZO/HlLtJ ENSMUSG00225044359
 protein coding gene Chr19:10451960-10452303 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010040995
 protein coding gene Chr19:5397814-5413831 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    SLC3A2, solute carrier family 3 member 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC3A2, solute carrier family 3 member 2
  • Synonyms
    4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
  • Links
    NCBI Gene ID: 6520
    UniProt: P08195

  • Chr Location
    11q12.3; chr11:62855970-62888910 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC3A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 5 genetic backgrounds
    4 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display embryonic lethality. Mice homozygous for a conditional allele activated in the intestinal epithelia exhibit resistance to decreased susceptibility to induced colitis and colitis-associated cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    102
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    946
  • Tissues
    66
  • cDNA Data
    379
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17254 NCBI Gene Model | MGI Sequence Detail 15803 C57BL/6J ±  kb
    transcript NM_001161413 RefSeq | MGI Sequence Detail 2128 C57BL/6  
    polypeptide P10852 UniProt | EBI | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000001851 amino acid transporter heavy chain SLC3A2
      (term hierarchy)
    • PDB
      6I9Q, 6SUA
    • InterPro Domains
      IPR042280 Amino acid transporter heavy chain SLC3A2
      IPR017853 Glycoside hydrolase superfamily
      IPR013780 Glycosyl hydrolase, all-beta
      IPR006047 Glycosyl hydrolase family 13, catalytic domain
      IPR031984 Solute carrier family 3 member 2, N-terminal domain
    • GlyGen
      P10852 9 sites, 11 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 383
      cDNA 379
      Primer pair 3
      Other 1
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11948, MGD-MRK-12009, MGD-MRK-12016, MGD-MRK-12179, MGD-MRK-12223, MGD-MRK-35053, MGI:106597, MGI:2147500
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 9
      Gene Ontology 15
      Phenotypes 33
    • Earliest
      J:4451 Kimura S, et al., A new lymphocyte alloantigen (Ly-10) controlled by a gene linked to the Lyt-1 locus. Immunogenetics. 1980;10(4):363-72
    • Latest
      J:365597 Bhakuni T, et al., FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation. Nat Commun. 2024 May 16;15(1):4097
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory