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Ltk Gene Detail
Summary
  • Symbol
    Ltk
  • Name
    leukocyte tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:96840
    NCBI Gene: 17005
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:119581807-119590912 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 59.97 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    257 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96840
 protein coding gene Chr2:119581801-119590912 (-)
129S1/SvImJ ENSMUSG00200046433
 protein coding gene Chr2:116533740-116542731 (-)
A/J ENSMUSG00195022579
 protein coding gene Chr2:116575574-116584525 (-)
AKR/J ENSMUSG00220036963
 protein coding gene Chr2:116497693-116506680 (-)
BALB/cJ ENSMUSG00180038988
 protein coding gene Chr2:116375934-116384886 (-)
C3H/HeJ ENSMUSG00175024694
 protein coding gene Chr2:116840948-116849942 (-)
C57BL/6NJ ENSMUSG00215020031
 protein coding gene Chr2:116499228-116508339 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024152
 protein coding gene Chr2:112588516-112597925 (-)
CAST/EiJ ENSTCUG00005016192
 protein coding gene Chr2:115780256-115789238 (-)
CBA/J ENSMUSG00210006972
 protein coding gene Chr2:116681923-116690917 (-)
DBA/2J ENSMUSG00185041520
 protein coding gene Chr2:116373637-116382588 (-)
FVB/NJ ENSMUSG00205039913
 protein coding gene Chr2:115598485-115607472 (-)
JF1/MsJ ENSUMUG00000020640
 protein coding gene Chr2:116247971-116257082 (-)
LP/J ENSMUSG00230021245
 protein coding gene Chr2:118192759-118202256 (-)
NOD/ShiLtJ ENSMUSG00190044611
 protein coding gene Chr2:116610110-116619110 (-)
NZO/HlLtJ ENSMUSG00225004227
 protein coding gene Chr2:126088470-126097464 (-)
PWK/PhJ ENSLUMG00010046594
 protein coding gene Chr2:116149318-116158421 (-)
SPRET/EiJ ENSMSPG00010036925
 protein coding gene Chr2:118551287-118560242 (-)
WSB/EiJ ENSIUOG00005026437
 protein coding gene Chr2:116337298-116346278 (-)



Homology
more
  • Human Ortholog
    LTK, leukocyte receptor tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LTK, leukocyte receptor tyrosine kinase
  • Synonyms
    TYK1
  • Links
    NCBI Gene ID: 4058
    UniProt: P29376

  • Chr Location
    15q15.1; chr15:41503634-41513887 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    637
  • Tissues
    29
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17005 NCBI Gene Model | MGI Sequence Detail 9106 C57BL/6J ±  kb
    transcript NM_203345 RefSeq | MGI Sequence Detail 3115 Not Specified  
    polypeptide P08923 UniProt | EBI | MGI Sequence Detail 888 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 4
      cDNA 15
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11904
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:385781 Tang T, et al., Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons. J Neurosci. 2026 Apr 8;46(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory