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Lhb Gene Detail
Summary
  • Symbol
    Lhb
  • Name
    luteinizing hormone beta
  • Synonyms
    Gm29035, leutropin, LH
  • Feature Type
    protein coding gene
  • IDs
    MGI:96782
    NCBI Gene: 16866
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45070370-45071278 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.30 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    3
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96782
 protein coding gene Chr7:45067777-45071321 (+)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0029717
 protein coding gene Chr7:47358299-47359333 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210044126
 protein coding gene Chr7:34471854-34475398 (+)
DBA/2J no annotation
FVB/NJ no annotation
JF1/MsJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CGB1, chorionic gonadotropin subunit beta 1
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CGB1, chorionic gonadotropin subunit beta 1
  • Links
    NCBI Gene ID: 114335
    UniProt: A6NKQ9

  • Chr Location
    19q13.33; chr19:49035569-49036895 (-)  GRCh38
  • Human Ortholog
    CGB2, chorionic gonadotropin subunit beta 2
  • Links
    NCBI Gene ID: 114336
    UniProt: Q6NT52

  • Chr Location
    19q13.33; chr19:49031890-49033238 (+)  GRCh38
  • Human Ortholog
    CGB3, chorionic gonadotropin subunit beta 3
  • Synonyms
    CGB, CG-beta
  • Links
    NCBI Gene ID: 1082
    UniProt: P0DN86

  • Chr Location
    19q13.33; chr19:49022869-49024333 (-)  GRCh38
  • Human Ortholog
    CGB5, chorionic gonadotropin subunit beta 5
  • Synonyms
    CGB, HCG
  • Links
    NCBI Gene ID: 93659

  • Chr Location
    19q13.33; chr19:49043848-49045311 (+)  GRCh38
  • Human Ortholog
    CGB7, chorionic gonadotropin subunit beta 7
  • Synonyms
    CGB6, CG-beta-a
  • Links
    NCBI Gene ID: 94027
    UniProt: P0DN87

  • Chr Location
    19q13.33; chr19:49054274-49058860 (-)  GRCh38
  • Human Ortholog
    CGB8, chorionic gonadotropin subunit beta 8
  • Links
    NCBI Gene ID: 94115

  • Chr Location
    19q13.33; chr19:49047638-49049125 (-)  GRCh38
  • Human Ortholog
    LHB, luteinizing hormone subunit beta
  • Synonyms
    CGB4, HH23, LSH-B, LSH-beta
  • Links
    NCBI Gene ID: 3972
    UniProt: P01229

  • Chr Location
    19q13.33; chr19:49015980-49019498 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LHB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display male and female infertility, hypogonadism, azoospermia, absent corpora lutea, degenerating oocytes, and reduced serum levels of estradiol, progesterone, and testosterone.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    134
  • Tissues
    65
  • cDNA Data
    8
  • Literature Summary
    121
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16866 NCBI Gene Model | MGI Sequence Detail 909 C57BL/6J ±  kb
    transcript NM_008497 RefSeq | MGI Sequence Detail 509 ZRU/MplStud  
    polypeptide O09108 UniProt | EBI | MGI Sequence Detail 141 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 3
      cDNA 11
      Primer pair 6
      Other 2
      Antibodies 21

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11802, MGI:5579741
    References
    more
    • Summaries
      All 202
      Developmental Gene Expression 121
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:7285 Naylor SL, et al., Chromosome assignment of genes encoding the alpha and beta subunits of glycoprotein hormones in man and mouse. Somatic Cell Genet. 1983 Nov;9(6):757-70
    • Latest
      J:388801 Das P, et al., NR3C1 is required for normal somatotrope differentiation and Foxo1 expression in pituitary. Endocrinology. 2026 May 26;167(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory