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Igfbp5 Gene Detail
Summary
  • Symbol
    Igfbp5
  • Name
    insulin-like growth factor binding protein 5
  • Synonyms
    IGFBP-5, IGFBP-5P
  • Feature Type
    protein coding gene
  • IDs
    MGI:96440
    NCBI Gene: 16011
  • Alliance
    genome feature page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:72897224-72914024 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 36.94 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    496 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96440
 protein coding gene Chr1:72897091-72914043 (-)
129S1/SvImJ ENSMUSG00200004336
 protein coding gene Chr1:70559540-70576495 (-)
A/J ENSMUSG00195029724
 protein coding gene Chr1:69973293-69990276 (-)
AKR/J ENSMUSG00220035765
 protein coding gene Chr1:70125244-70142203 (-)
BALB/cJ ENSMUSG00180028711
 protein coding gene Chr1:70238057-70255010 (-)
C3H/HeJ ENSMUSG00175000752
 protein coding gene Chr1:70368604-70385589 (-)
C57BL/6NJ ENSMUSG00215017942
 protein coding gene Chr1:70283853-70300807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014249
 protein coding gene Chr1:66467912-66484532 (-)
CAST/EiJ ENSTCUG00005020252
 protein coding gene Chr1:70030523-70047497 (-)
CBA/J ENSMUSG00210003073
 protein coding gene Chr1:70066017-70082969 (-)
DBA/2J ENSMUSG00185004815
 protein coding gene Chr1:71156020-71172990 (-)
FVB/NJ ENSMUSG00205012917
 protein coding gene Chr1:69792682-69809637 (-)
JF1/MsJ ENSUMUG00000003441
 protein coding gene Chr1:70066159-70083138 (-)
LP/J ENSMUSG00230002048
 protein coding gene Chr1:71150743-71167696 (-)
NOD/ShiLtJ ENSMUSG00190013509
 protein coding gene Chr1:70283063-70300041 (-)
NZO/HlLtJ ENSMUSG00225039778
 protein coding gene Chr1:74365864-74382817 (-)
PWK/PhJ ENSLUMG00010007380
 protein coding gene Chr1:69665389-69682353 (-)
SPRET/EiJ ENSMSPG00010019067
 protein coding gene Chr1:71744495-71757018 (-)
WSB/EiJ ENSIUOG00005028343
 protein coding gene Chr1:69935624-69952597 (-)



Homology
more
  • Human Ortholog
    IGFBP5, insulin like growth factor binding protein 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGFBP5, insulin like growth factor binding protein 5
  • Synonyms
    IBP5
  • Links
    NCBI Gene ID: 3488
    UniProt: P24593

  • Chr Location
    2q35; chr2:216672105-216695549 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotypes from multigenic genotypes
    20 phenotype references
Mice homozygous for one knock-out allele exhibit normal body weight and normal glucose homeostasis relative to wild-type controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    993
  • Tissues
    238
  • cDNA Data
    930
  • Literature Summary
    89
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16011 NCBI Gene Model | MGI Sequence Detail 16801 C57BL/6J ±  kb
transcript NM_010518 RefSeq | MGI Sequence Detail 5854 FVB/N  
polypeptide Q07079 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008951 insulin-like growth factor-binding protein 5
    (term hierarchy)
  • InterPro Domains
    IPR009030 Growth factor receptor cysteine-rich domain superfamily
    IPR012213 Insulin-like growth factor binding protein 5
    IPR022321 Insulin-like growth factor-binding protein family 1-6, chordata
    IPR000867 Insulin-like growth factor-binding protein, IGFBP
    IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
    IPR000716 Thyroglobulin type-1
    IPR036857 Thyroglobulin type-1 superfamily
Molecular
Reagents
less
  • All nucleic 947
    Genomic 4
    cDNA 935
    Primer pair 5
    Other 3
    Antibodies 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-11237, MGI:2138187, MGI:2138571
References
more
  • Summaries
    All 179
    Developmental Gene Expression 89
    Gene Ontology 21
    Phenotypes 20
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:389400 Zhang Y, et al., Stem cell control in the lung by an autocrine injury-activated Igf complex. Science. 2026 Apr 16;392(6795):eadt1310
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory