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Gsx1 Gene Detail
Summary
  • Symbol
    Gsx1
  • Name
    GS homeobox 1
  • Synonyms
    Gsh-1, Gsh1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95842
    NCBI Gene: 14842
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:147125506-147127757 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 86.79 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95842
 protein coding gene Chr5:147125492-147127757 (+)
129S1/SvImJ ENSMUSG00200040822
 protein coding gene Chr5:140957078-140959347 (+)
A/J ENSMUSG00195040625
 protein coding gene Chr5:140565122-140567391 (+)
AKR/J ENSMUSG00220022783
 protein coding gene Chr5:139569758-139572008 (+)
BALB/cJ ENSMUSG00180027726
 protein coding gene Chr5:140947611-140949871 (+)
C3H/HeJ ENSMUSG00175011303
 protein coding gene Chr5:142788502-142790765 (+)
C57BL/6NJ ENSMUSG00215039852
 protein coding gene Chr5:140514930-140517187 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028035
 protein coding gene Chr5:140774020-140776296 (+)
CAST/EiJ ENSTCUG00005032513
 protein coding gene Chr5:140086451-140088727 (+)
CBA/J ENSMUSG00210023588
 protein coding gene Chr5:141705718-141707965 (+)
DBA/2J ENSMUSG00185037195
 protein coding gene Chr5:144676814-144679052 (+)
FVB/NJ ENSMUSG00205028196
 protein coding gene Chr5:140323932-140326241 (+)
JF1/MsJ ENSUMUG00000039765
 protein coding gene Chr5:147166362-147168679 (+)
LP/J ENSMUSG00230028955
 protein coding gene Chr5:148673978-148676249 (+)
NOD/ShiLtJ ENSMUSG00190025679
 protein coding gene Chr5:140319100-140321378 (+)
NZO/HlLtJ ENSMUSG00225007944
 protein coding gene Chr5:156420588-156422853 (+)
PWK/PhJ ENSLUMG00010020423
 protein coding gene Chr5:139402994-139405282 (+)
SPRET/EiJ ENSMSPG00010006238
 protein coding gene Chr5:142211340-142213584 (+)
WSB/EiJ ENSIUOG00005013514
 protein coding gene Chr5:143095508-143097760 (+)



Homology
more
  • Human Ortholog
    GSX1, GS homeobox 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GSX1, GS homeobox 1
  • Synonyms
    Gsh-1, GSH1
  • Links
    NCBI Gene ID: 219409
    UniProt: Q9H4S2

  • Chr Location
    13q12.2; chr13:27792483-27794768 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show partial neonatal and peri-weaning lethality, delayed eyelid opening, dwarfism, multiple hormone deficiencies, aberrant pituitary development, hypothalamic dysfunction, altered bone epiphyseal growth plates, low WBC counts, infertility and premature death.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    939
  • Tissues
    246
  • cDNA Data
    7
  • Literature Summary
    56
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000053129 Ensembl Gene Model | MGI Sequence Detail 2252 C57BL/6J ±  kb
    transcript ENSMUST00000065382 Ensembl | MGI Sequence Detail 1773 Not Applicable  
    polypeptide ENSMUSP00000069728 Ensembl | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 9
      Primer pair 3
      Other 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10284, MGD-MRK-10289
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 56
      Gene Ontology 11
      Phenotypes 21
    • Earliest
      J:1775 Singh G, et al., Identification of 10 murine homeobox genes. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10706-10
    • Latest
      J:377967 Roome RB, et al., Ontogeny of the spinal cord dorsal horn. Science. 2026 Jan 8;391(6781):eadx5781
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory