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Got1 Gene Detail
Summary
  • Symbol
    Got1
  • Name
    glutamic-oxaloacetic transaminase 1, soluble
  • Synonyms
    cAspAT, cytosolic aspartate aminotransferase, Got-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95791
    NCBI Gene: 14718
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:43488191-43513044 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.67 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    977 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95791
 protein coding gene Chr19:43488191-43514743 (-)
129S1/SvImJ ENSMUSG00200028000
 protein coding gene Chr19:40212113-40237013 (-)
A/J ENSMUSG00195017190
 protein coding gene Chr19:40319432-40344286 (-)
AKR/J ENSMUSG00220018477
 protein coding gene Chr19:40131549-40156462 (-)
BALB/cJ ENSMUSG00180019554
 protein coding gene Chr19:40571862-40596708 (-)
C3H/HeJ ENSMUSG00175006178
 protein coding gene Chr19:40122245-40147142 (-)
C57BL/6NJ ENSMUSG00215016206
 protein coding gene Chr19:40177845-40202698 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022980
 protein coding gene Chr19:40155699-40180844 (-)
CAST/EiJ ENSTCUG00005014538
 protein coding gene Chr19:39768548-39792932 (-)
CBA/J ENSMUSG00210032048
 protein coding gene Chr19:40201935-40226822 (-)
DBA/2J ENSMUSG00185008792
 protein coding gene Chr19:40695575-40720419 (-)
FVB/NJ ENSMUSG00205006250
 protein coding gene Chr19:39635557-39660456 (-)
JF1/MsJ ENSUMUG00000021241
 protein coding gene Chr19:40861254-40885527 (-)
LP/J ENSMUSG00230023533
 protein coding gene Chr19:41482122-41507020 (-)
NOD/ShiLtJ ENSMUSG00190010576
 protein coding gene Chr19:40045366-40070212 (-)
NZO/HlLtJ ENSMUSG00225041566
 protein coding gene Chr19:45069873-45095039 (-)
PWK/PhJ ENSLUMG00010000964
 protein coding gene Chr19:40028328-40052564 (-)
SPRET/EiJ ENSMSPG00010022563
 protein coding gene Chr19:39773512-39797580 (-)
WSB/EiJ ENSIUOG00005034455
 protein coding gene Chr19:39576985-39601828 (-)



Homology
more
  • Human Ortholog
    GOT1, glutamic-oxaloacetic transaminase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GOT1, glutamic-oxaloacetic transaminase 1
  • Synonyms
    AST, AST1, ASTQTL1, cAspAT, cCAT, GIG18, SGOT
  • Links
    NCBI Gene ID: 2805
    UniProt: P17174

  • Chr Location
    10q24.2; chr10:99396870-99430671 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human GOT1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    944
  • Tissues
    121
  • cDNA Data
    229
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025190 Ensembl Gene Model | MGI Sequence Detail 24854 C57BL/6J ±  kb
    transcript ENSMUST00000026196 Ensembl | MGI Sequence Detail 2058 Not Applicable  
    polypeptide ENSMUSP00000026196 Ensembl | MGI Sequence Detail 413 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008153 aspartate aminotransferase, cytoplasmic
      (term hierarchy)
    • EC
      2.6.1.1, 2.6.1.3
    • InterPro Domains
      IPR004839 Aminotransferase, class I/classII, large domain
      IPR004838 Aminotransferases, class-I, PLP site
      IPR000796 Aspartate/other aminotransferase
      IPR015424 Pyridoxal phosphate-dependent transferase
      IPR015421 Pyridoxal phosphate-dependent transferase, major domain
      IPR015422 Pyridoxal phosphate-dependent transferase, small domain
    • GlyGen
      P05201 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 236
      Genomic 5
      cDNA 230
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10213, MGD-MRK-10215, MGI:2147593
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 6
      Gene Ontology 18
      Phenotypes 20
    • Earliest
      J:5163 DeLorenzo RJ, et al., Glutamate oxalate transaminase (GOT) genetics in Mus musculus: linkage, polymorphism, and phenotypes of the Got-2 and Got-1 loci. Biochem Genet. 1970 Apr;4(2):259-73
    • Latest
      J:369609 Park CH, et al., Cold-inducible GOT1 activates the malate-aspartate shuttle in brown adipose tissue to support fuel preference for fatty acids. Cell Rep. 2025 Jun 19;44(7):115888
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory