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Slc6a13 Gene Detail
Summary
  • Symbol
    Slc6a13
  • Name
    solute carrier family 6 (neurotransmitter transporter, GABA), member 13
  • Synonyms
    Gabt3, Gat2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95629
    NCBI Gene: 14412
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:121277247-121314680 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 57.22 cM, cytoband F1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1100 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95629
 protein coding gene Chr6:121277186-121314692 (+)
129S1/SvImJ ENSMUSG00200047774
 protein coding gene Chr6:118476260-118515786 (+)
A/J ENSMUSG00195047072
 protein coding gene Chr6:117890474-117930003 (+)
AKR/J ENSMUSG00220021209
 protein coding gene Chr6:116775683-116815211 (+)
BALB/cJ ENSMUSG00180038308
 protein coding gene Chr6:118258133-118297666 (+)
C3H/HeJ ENSMUSG00175043151
 protein coding gene Chr6:117913461-117952984 (+)
C57BL/6NJ ENSMUSG00215048009
 protein coding gene Chr6:118244602-118282108 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028814
 protein coding gene Chr6:116361856-116399461 (+)
CAST/EiJ ENSTCUG00005050339
 protein coding gene Chr6:118047235-118084710 (+)
CBA/J ENSMUSG00210029599
 protein coding gene Chr6:118025077-118064601 (+)
DBA/2J ENSMUSG00185047207
 protein coding gene Chr6:118682859-118720464 (+)
FVB/NJ ENSMUSG00205043542
 protein coding gene Chr6:117124758-117162369 (+)
JF1/MsJ ENSUMUG00000048798
 protein coding gene Chr6:117283684-117321072 (+)
LP/J ENSMUSG00230040805
 protein coding gene Chr6:119873644-119913169 (+)
NOD/ShiLtJ ENSMUSG00190035427
 protein coding gene Chr6:117637919-117677449 (+)
NZO/HlLtJ ENSMUSG00225047218
 protein coding gene Chr6:121768360-121805964 (+)
PWK/PhJ ENSLUMG00010045959
 protein coding gene Chr6:116617357-116655007 (+)
SPRET/EiJ ENSMSPG00010040601
 protein coding gene Chr6:119494025-119531687 (+)
WSB/EiJ ENSIUOG00005035728
 protein coding gene Chr6:118288947-118326835 (+)



Homology
more
  • Human Ortholog
    SLC6A13, solute carrier family 6 member 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A13, solute carrier family 6 member 13
  • Synonyms
    GAT-2, GAT2, GAT3
  • Links
    NCBI Gene ID: 6540
    UniProt: Q9NSD5

  • Chr Location
    12p13.33; chr12:220621-262873 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced taurine levels in the liver and increased taurine levels in the brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    53
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1018
  • Tissues
    295
  • cDNA Data
    48
  • Literature Summary
    14
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14412 NCBI Gene Model | MGI Sequence Detail 37434 C57BL/6J ±  kb
transcript NM_001379107 RefSeq | MGI Sequence Detail 2293 C57BL/6  
polypeptide P31649 UniProt | EBI | MGI Sequence Detail 602 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015179 sodium- and chloride-dependent GABA transporter 2
    (term hierarchy)
  • InterPro Domains
    IPR000175 Sodium:neurotransmitter symporter
    IPR002981 Sodium:neurotransmitter symporter, GABA, GAT-2
    IPR037272 Sodium:neurotransmitter symporter superfamily
  • GlyGen
    P31649 4 sites
Molecular
Reagents
less
  • All nucleic 51
    cDNA 48
    Primer pair 3
    Antibodies 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9949
References
more
  • Summaries
    All 60
    Developmental Gene Expression 14
    Gene Ontology 9
    Phenotypes 7
  • Earliest
    J:3704 Liu QR, et al., Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected] [published erratum appers in J Biol Chem 1993 Apr 25;268(12):9156]. J Biol Chem. 1993 Jan 25;268(3):2106-12
  • Latest
    J:345075 Wang XW, et al., Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways. J Clin Invest. 2024 Feb 1;134(3)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory