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Gabrb1 Gene Detail
Summary
  • Symbol
    Gabrb1
  • Name
    gamma-aminobutyric acid type A receptor subunit beta 1
  • Synonyms
    B230208N19Rik, Gabrb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95619
    NCBI Gene: 14400
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:71815456-72306380 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 38.18 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11865 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95619
 protein coding gene Chr5:71815264-72306915 (+)
129S1/SvImJ ENSMUSG00200034258
 protein coding gene Chr5:67472113-67963639 (+)
A/J ENSMUSG00195029833
 protein coding gene Chr5:66796365-67287857 (+)
AKR/J ENSMUSG00220004304
 protein coding gene Chr5:66906452-67399513 (+)
BALB/cJ ENSMUSG00180019945
 protein coding gene Chr5:66549187-67044865 (+)
C3H/HeJ ENSMUSG00175024711
 protein coding gene Chr5:68617612-69096858 (+)
C57BL/6NJ ENSMUSG00215004814
 protein coding gene Chr5:67381640-67879001 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027280
 protein coding gene Chr5:64625193-65089285 (+)
CAST/EiJ ENSTCUG00005028770
 protein coding gene Chr5:66376985-66850737 (+)
CBA/J ENSMUSG00210023144
 protein coding gene Chr5:67555851-68035049 (+)
DBA/2J ENSMUSG00185005461
 protein coding gene Chr5:69385473-69864682 (+)
FVB/NJ ENSMUSG00205019353
 protein coding gene Chr5:66353846-66840235 (+)
JF1/MsJ ENSUMUG00000003892
 protein coding gene Chr5:73841174-74335531 (+)
LP/J ENSMUSG00230019787
 protein coding gene Chr5:74046548-74538087 (+)
NOD/ShiLtJ ENSMUSG00190003957
 protein coding gene Chr5:66484434-66963610 (+)
NZO/HlLtJ ENSMUSG00225009270
 protein coding gene Chr5:79116765-79608255 (+)
PWK/PhJ ENSLUMG00010013908
 protein coding gene Chr5:66430557-66918201 (+)
SPRET/EiJ ENSMSPG00010029262
 protein coding gene Chr5:68367208-68888109 (+)
WSB/EiJ ENSIUOG00005016547
 protein coding gene Chr5:69310242-69804148 (+)



Homology
more
  • Human Ortholog
    GABRB1, gamma-aminobutyric acid type A receptor subunit beta1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GABRB1, gamma-aminobutyric acid type A receptor subunit beta1
  • Synonyms
    DEE45, EIEE45
  • Links
    NCBI Gene ID: 2560
    UniProt: P18505

  • Chr Location
    4p12; chr4:46993647-47426447 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human GABRB1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for an ENU or spontaneous mutation exhibit alcohol preference with increased tonic inhibition, female infertility and hypothalamic pituitary axis dysfunction.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    168
  • cDNA Data
    15
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029212 Ensembl Gene Model | MGI Sequence Detail 490925 C57BL/6J ±  kb
    transcript ENSMUST00000031122 Ensembl | MGI Sequence Detail 13737 Not Applicable  
    polypeptide ENSMUSP00000031122 Ensembl | MGI Sequence Detail 474 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000007772 gamma-aminobutyric acid receptor subunit beta-1
      (term hierarchy)
    • InterPro Domains
      IPR002289 Gamma-aminobutyric-acid A receptor, beta subunit
      IPR006028 Gamma-aminobutyric acid A receptor/Glycine receptor alpha
      IPR038050 Neuronal acetylcholine receptor
      IPR006201 Neurotransmitter-gated ion-channel
      IPR018000 Neurotransmitter-gated ion-channel, conserved site
      IPR006202 Neurotransmitter-gated ion-channel ligand-binding domain
      IPR036734 Neurotransmitter-gated ion-channel ligand-binding domain superfamily
      IPR006029 Neurotransmitter-gated ion-channel transmembrane domain
      IPR036719 Neurotransmitter-gated ion-channel transmembrane domain superfamily
    • GlyGen
      P50571 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 13
      cDNA 16
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9933, MGD-MRK-9936, MGI:2141149, MGI:2443656
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 16
      Gene Ontology 10
      Phenotypes 31
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:388828 Deng SM, et al., ARHGAP39 plays an essential role in anxiety-like behavior and stress response. Transl Psychiatry. 2026 May 9;16(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory