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Fos Gene Detail
Summary
  • Symbol
    Fos
  • Name
    Fos proto-oncogene, AP-1 transcription factor subunit
  • Synonyms
    c-fos, cFos, D12Rfj1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95574
    NCBI Gene: 14281
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:85520664-85524047 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 39.70 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    2
  • RFLP
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95574
 protein coding gene Chr12:85520664-85524048 (+)
129S1/SvImJ ENSMUSG00200048845
 protein coding gene Chr12:77535859-77539245 (+)
A/J ENSMUSG00195029382
 protein coding gene Chr12:80155485-80158870 (+)
AKR/J ENSMUSG00220045717
 protein coding gene Chr12:77951417-77954802 (+)
BALB/cJ ENSMUSG00180018300
 protein coding gene Chr12:79193216-79196601 (+)
C3H/HeJ ENSMUSG00175037149
 protein coding gene Chr12:82286305-82289691 (+)
C57BL/6NJ ENSMUSG00215043372
 protein coding gene Chr12:78499685-78503069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017967
 protein coding gene Chr12:79863165-79866562 (+)
CAST/EiJ ENSTCUG00005030402
 protein coding gene Chr12:78461309-78464700 (+)
CBA/J ENSMUSG00210042560
 protein coding gene Chr12:78699500-78702884 (+)
DBA/2J ENSMUSG00185002394
 protein coding gene Chr12:80556759-80560143 (+)
FVB/NJ ENSMUSG00205019336
 protein coding gene Chr12:78368273-78371659 (+)
JF1/MsJ ENSUMUG00000036830
 protein coding gene Chr12:84542421-84545793 (+)
LP/J ENSMUSG00230042089
 protein coding gene Chr12:87618969-87622353 (+)
NOD/ShiLtJ ENSMUSG00190032276
 protein coding gene Chr12:77756518-77759901 (+)
NZO/HlLtJ ENSMUSG00225051654
 protein coding gene Chr12:89656072-89659455 (+)
PWK/PhJ ENSLUMG00010027785
 protein coding gene Chr12:78559041-78562416 (+)
SPRET/EiJ ENSMSPG00010016212
 protein coding gene Chr12:80377485-80380869 (+)
WSB/EiJ ENSIUOG00005042592
 protein coding gene Chr12:78407983-78411357 (+)



Homology
more
  • Human Ortholog
    FOS, Fos proto-oncogene, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOS, Fos proto-oncogene, AP-1 transcription factor subunit
  • Synonyms
    AP-1, C-FOS, p55
  • Links
    NCBI Gene ID: 2353
    UniProt: P01100

  • Chr Location
    14q24.3; chr14:75278826-75283190 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    118 phenotypes from 13 alleles in 14 genetic backgrounds
    23 phenotypes from multigenic genotypes
    4 images
    464 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutants are growth-retarded, most dying perinatally. Survivors have osteopetrosis and abnormal tooth eruption, gametogenesis, hemopoiesis, behavior and photoreceptor apoptosis. Hippocampal-specific mutants have seizures and highly excitable neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    147
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1119
  • Tissues
    299
  • cDNA Data
    13
  • Literature Summary
    129
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021250 Ensembl Gene Model | MGI Sequence Detail 3384 C57BL/6J ±  kb
    transcript ENSMUST00000021674 Ensembl | MGI Sequence Detail 2108 Not Applicable  
    polypeptide ENSMUSP00000021674 Ensembl | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 10
      cDNA 18
      Primer pair 19
      Other 6
      Antibodies 11

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-19548, MGD-MRK-9866
    References
    more
    • Summaries
      All 881
      Developmental Gene Expression 129
      Gene Ontology 31
      Phenotypes 464
    • Earliest
      J:6867 Muller R, et al., Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature. 1982 Oct 14;299(5884):640-4
    • Latest
      J:391300 Cupolillo D, et al., Deep learning-assisted mapping of dendritic spines using sequential 2D two-photon calcium imaging. iScience. 2026 Aug 21;29(8):117010
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory